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Recent Progress in Structures and Functions of Hepatitis C Virus NS3/4A Proteins [PDF]

Viruses
Hepatitis C virus (HCV) chronically infects over 50 million people worldwide and poses a significant risk to global health. The HCV NS3/4A complex, a bifunctional enzyme comprising a protease and a helicase domain, is indispensable for viral replication ...
Keyang Huang, Manfeng Zhang, Yihua Huang, Zhongzhou Chen   +3 more
doaj   +2 more sources

The Impact of Next Generation Sequencing in Diagnosis and Management of Rare Diseases: Bloom Syndrome [PDF]

Modern Medicine, 2022
Bloom syndrome is an exceptionally rare autosomal recessive disorder characterized by a considerable genomic instability due to the defective DNA damage repair machine.
Ina-Ofelia FOCSA, Andreea TUTULAN-CUNITA, Anca PAVEL, Diana PREPELITA, Diana BRATU, Laurentiu Camil BOHILTEA, Danae STAMBOULI   +6 more
doaj   +1 more source

Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops

eLife, 2021
The PcrA/UvrD helicase binds directly to RNA polymerase (RNAP) but the structural basis for this interaction and its functional significance have remained unclear.
Inigo Urrutia-Irazabal, James R Ault, Frank Sobott, Nigel J Savery, Mark S Dillingham   +4 more
doaj   +1 more source

UPF1—From mRNA Degradation to Human Disorders

Cells, 2023
Up-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react in the event of an incorrect translation mechanism.
Jacek Staszewski, Natalia Lazarewicz, Julia Konczak, Iwona Migdal, Ewa Maciaszczyk-Dziubinska   +4 more
doaj   +1 more source

Z-RNA and the Flipside of the SARS Nsp13 Helicase: Is There a Role for Flipons in Coronavirus-Induced Pathology?

Frontiers in Immunology, 2022
We present evidence suggesting that the severe acute respiratory syndrome (SARS) coronavirus non-structural protein 13 (Nsp13) modulates the Z-RNA dependent regulated cell death pathways .
Alan Herbert, Alan Herbert, Maria Poptsova   +2 more
doaj   +1 more source

Therapeutic potential of compounds targeting SARS-CoV-2 helicase

Frontiers in Chemistry, 2022
The economical and societal impact of COVID-19 has made the development of vaccines and drugs to combat SARS-CoV-2 infection a priority. While the SARS-CoV-2 spike protein has been widely explored as a drug target, the SARS-CoV-2 helicase (nsp13) does ...
Matthew T. J. Halma, Matthew T. J. Halma, Mark J. A. Wever, Mark J. A. Wever, Sanne Abeln, Didier Roche, Gijs J. L. Wuite   +6 more
doaj   +1 more source

ATPase cycle and DNA unwinding kinetics of RecG helicase [PDF]

, 2012
The superfamily 2 bacterial helicase, RecG, is a monomeric enzyme with a role in DNA repair by reversing stalled replication forks. The helicase must act specifically and rapidly to prevent replication fork collapse. We have shown that RecG binds tightly
Powell, Ben, Toseland, Christopher P., Webb, Martin R   +2 more
core   +10 more sources

The enigmatic helicase DHX9 and its association with the hallmarks of cancer

Future Science OA, 2021
Much interest has been expended lately in characterizing the association between DExH-Box helicase 9 (DHX9) dysregulation and malignant development, however, the enigmatic nature of DHX9 has caused conflict as to whether it regularly functions as an ...
Chloe Gulliver, Ralf Hoffmann, George S Baillie   +2 more
doaj   +1 more source

Duplex DNA from Sites of Helicase-Polymerase Uncoupling Links Non-B DNA Structure Formation to Replicative Stress [PDF]

, 2020
BACKGROUND: Replication impediments can produce helicase-polymerase uncoupling allowing lagging strand synthesis to continue for as much as 6 kb from the site of the impediment.
Abdelhamid, Mahmoud A S, Amparo, Camille, Bedell, Victoria, Clark, Jarrod, Martella, Marianna, Murata-Collins, Joyce L, Pichiorri, Flavia, Smith, Steven S, Waller, Zoë A E, Warner, Emily F   +9 more
core   +2 more sources

A Proof of Principle for the Detection of Viable Brucella spp. in Raw Milk by qPCR Targeting Bacteriophages

Microorganisms, 2020
Brucellosis is still a global health issue, and surveillance and control of this zoonotic disease in livestock remains a challenge. Human outbreaks are mainly linked to the consumption of unpasteurized dairy products.
Michaela Projahn, Jens A. Hammerl, Ralf Dieckmann, Sascha Al Dahouk   +3 more
doaj   +1 more source