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Recent Progress in Structures and Functions of Hepatitis C Virus NS3/4A Proteins [PDF]
VirusesHepatitis C virus (HCV) chronically infects over 50 million people worldwide and poses a significant risk to global health. The HCV NS3/4A complex, a bifunctional enzyme comprising a protease and a helicase domain, is indispensable for viral replication ...
Keyang Huang +3 more
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The Impact of Next Generation Sequencing in Diagnosis and Management of Rare Diseases: Bloom Syndrome [PDF]
Modern Medicine, 2022 Bloom syndrome is an exceptionally rare autosomal recessive disorder characterized by a considerable genomic instability due to the defective DNA damage repair machine.
Ina-Ofelia FOCSA +6 more
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eLife, 2021 The PcrA/UvrD helicase binds directly to RNA polymerase (RNAP) but the structural basis for this interaction and its functional significance have remained unclear.
Inigo Urrutia-Irazabal +4 more
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UPF1—From mRNA Degradation to Human Disorders
Cells, 2023 Up-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react in the event of an incorrect translation mechanism.
Jacek Staszewski +4 more
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Frontiers in Immunology, 2022 We present evidence suggesting that the severe acute respiratory syndrome (SARS) coronavirus non-structural protein 13 (Nsp13) modulates the Z-RNA dependent regulated cell death pathways .
Alan Herbert +2 more
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Therapeutic potential of compounds targeting SARS-CoV-2 helicase
Frontiers in Chemistry, 2022 The economical and societal impact of COVID-19 has made the development of vaccines and drugs to combat SARS-CoV-2 infection a priority. While the SARS-CoV-2 spike protein has been widely explored as a drug target, the SARS-CoV-2 helicase (nsp13) does ...
Matthew T. J. Halma +6 more
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The enigmatic helicase DHX9 and its association with the hallmarks of cancer
Future Science OA, 2021 Much interest has been expended lately in characterizing the association between DExH-Box helicase 9 (DHX9) dysregulation and malignant development, however, the enigmatic nature of DHX9 has caused conflict as to whether it regularly functions as an ...
Chloe Gulliver +2 more
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Microorganisms, 2020 Brucellosis is still a global health issue, and surveillance and control of this zoonotic disease in livestock remains a challenge. Human outbreaks are mainly linked to the consumption of unpasteurized dairy products.
Michaela Projahn +3 more
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Frontiers in Microbiology, 2018 Chromosomal replication initiation requires dynamic mechanisms in higher-order nucleoprotein complexes that are constructed at the origin of replication.
Yukari Sakiyama +5 more
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A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding
eLife, 2019 Licensing of eukaryotic origins of replication requires DNA loading of two copies of the Mcm2-7 replicative helicase to form a head-to-head double-hexamer, ensuring activated helicases depart the origin bidirectionally.
Kanokwan Champasa +4 more
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