Results 1 to 10 of about 1,085,799 (219)
Nature Communications, 2021 Ring ATPase translocases that operate on disordered substrates adopt lockwasher architectures and use a hand-over-hand mechanism. By challenging the dsDNA packaging motor of bacteriophage ϕ29 with hybrid and dsRNA, the authors propose that the motor ...
Juan P. Castillo +4 more
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An anionic ligand snap-locks a long-range interaction in a magnesium-folded riboswitch
Nature Communications, 2022 A single molecule fluorescence study revealed three dynamically interconverting conformations of the fluoride riboswitch from Bacillus cereus, where an anionic ligand snap-locks a docked conformation through a long-range interaction necessary for ...
Rajeev Yadav +3 more
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Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
Nature Communications, 2020 During eukaryotic chromosome replication cells utilize ring-shaped CMG helicase that separates the two strands of the DNA double helix. Here the authors reveal that CMG helicase activity is inhibited by duplex DNA engagement at the fork, which is ...
Hazal B. Kose +4 more
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Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein
Communications Biology, 2021 To better understand the specific cascade of protein interactions that lead to the pathological aggregation of α-synuclein (wild-type and mutant forms), Leitão et al.
André D. G. Leitão +7 more
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Single-molecule FRET uncovers hidden conformations and dynamics of human Argonaute 2
Nature Communications, 2022 Single-molecule FRET measurements provide detailed insights into the conformational states and dynamics of human Argonaute 2 that are required for its function at the core of the eukaryotic RNA silencing pathway.
Sarah Willkomm +6 more
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BMC Biology, 2018 Background Higher-order self-assembly of proteins, or “prion-like” polymerisation, is now emerging as a simple and robust mechanism for signal amplification, in particular within the innate immune system, where the recognition of pathogens or danger ...
Ailís O’Carroll +11 more
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Spontaneous Confinement of mRNA Molecules at Biomolecular Condensate Boundaries
Cells, 2023 Cellular biomolecular condensates, termed ribonucleoprotein (RNP) granules, are often enriched in messenger RNA (mRNA) molecules relative to the surrounding cytoplasm.
Rebecca T. Perelman +3 more
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Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin
Nature Communications, 2023 Force transmission at integrin-based adhesions is important for cell migration and mechanosensing. Talin is an essential focal adhesion (FA) protein that links F-actin to integrins.
Sawako Yamashiro +5 more
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Direct-laser writing for subnanometer focusing and single-molecule imaging
Nature Communications, 2022 Focus-locking improves localization precision in single-molecule microscopy, but fiducials are often deposited at random and provide limited 3D compensation.
Simao Coelho +4 more
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eLife, 2022 Single molecule imaging has shown that part of actin disassembles within a few seconds after incorporation into the dendritic filament network in lamellipodia, suggestive of frequent destabilization near barbed ends.
Danielle Holz +5 more
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