Results 11 to 20 of about 1,085,849 (268)
Single-Molecule Biodosimetry. [PDF]
Anal ChemInferring characteristics of radiation exposure using biological molecules is extremely challenging. Current methods, in particular, lack a clear connection between dose and molecular response. Here, we demonstrate that resistive–pulse nanopore sensors enable single–molecule biodosimetry by quantifying the frequency of double–strand ...
Lamontagne M +6 more
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Proceedings of the National Academy of Sciences, 2001 At first an experimental challenge, the ability to conduct experiments with single molecules has been strongly connected with progress in experimental techniques and instrumentation. Scanning probe techniques, such as the scanning tunneling microscope or the atomic force microscope (AFM), use sharp tips in close proximity (10−9 m) to a sample to ...
T, Basché, S, Nie, J M, Fernandez
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Single-Molecule Enzymology [PDF]
Journal of Biological Chemistry, 1999 Viewing a movie of an enzyme molecule made by molecular dynamics simulation, we see incredible details of molecular motions, be they changes of the conformation or actions during a chemical reaction. Molecular dynamics simulations have advanced our understanding of the dynamics of macromolecules in ways that would not be deducible from the static ...
X S, Xie, H P, Lu
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Single‐molecule bioelectronics [PDF]
WIREs Nanomedicine and Nanobiotechnology, 2014 Experimental techniques that interface single biomolecules directly with microelectronic systems are increasingly being used in a wide range of powerful applications, from fundamental studies of biomolecules to ultra‐sensitive assays. In this study, we review several technologies that can perform electronic measurements of single molecules in solution:
Rosenstein, Jacob K. +2 more
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Single-Photon Spectroscopy of a Single Molecule [PDF]
Physical Review Letters, 2012 Exploring the interaction of light and matter at the ultimate limit of single photons and single emitters is of great interest both from a fundamental point of view and for emerging applications in quantum engineering. However, the difficulty of generating single photons with specific wavelengths, bandwidths and brightness as well as the weak ...
Rezus, Y. +6 more
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Clinical Chemistry, 2011 The need for assay methods of sufficient sensitivity to determine the low concentrations of hormones present in body fluids led to the original development of immunoassays and analogous “binding” (or “ligand”) assays in the late 1950s and early 1960s. These methods depend on the use of a binding agent (also commonly referred to by other terms such as ...
Roger, Ekins, David, Kelso
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Single-Molecule Nanomagnets [PDF]
Annual Review of Condensed Matter Physics, 2010 Single-molecule magnets straddle the classical and quantum mechanical worlds, displaying many fascinating phenomena. They may have important technological applications in information storage and quantum computation. We review the physical properties of two prototypical molecular nanomagnets, Mn12-acetate and Fe8: Each behaves as a rigid, spin-10 ...
Friedman, Jonathan R. +1 more
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Single Molecule Nanometronome [PDF]
Nano Letters, 2006 We constructed a DNA-based nanomechanical device called the nanometronome. Our device is made by introducing complementary single-stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the ...
Chittanon, Buranachai +2 more
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Nature Communications, 2016 In response to intracellular signals, bacterial translational riboswitches embedded in mRNAs can regulate gene expression through inhibition of translation initiation.
Arlie J. Rinaldi +3 more
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Verification of Single-Molecule Imaging and Single-Molecule Measurements
Journal of Robotics and Mechatronics, 2010 Single-molecule imaging and single-molecule measurements constitute an integral part of life science researches. The research method, which allows direct measurements of individual motions and events of biomolecules, has contributed much to the development of life science research by providing us with numerous findings. It is left up to the judgment of
Akihiko Ishijima +2 more
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