Results 31 to 40 of about 132,729 (299)

Mechanisms of hexameric helicases [PDF]

open access: yesCritical Reviews in Biochemistry and Molecular Biology, 2021
Ring-shaped hexameric helicases are essential motor proteins that separate duplex nucleic acid strands for DNA replication, recombination, and transcriptional regulation. Two evolutionarily distinct lineages of these enzymes, predicated on RecA and AAA+ ATPase folds, have been identified and characterized to date.
Amy J. Fernandez, James M. Berger
openaire   +2 more sources

Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD [PDF]

open access: yes, 2013
The helicase PcrA unwinds DNA during asymmetric replication of plasmids, acting with an initiator protein, in our case RepD. Detailed kinetics of PcrA activity were measured using bulk solution and a single-molecule imaging technique to investigate the ...
Fili, Natalia   +7 more
core   +1 more source

Biological roles of DExH RNA helicase, RHAU [PDF]

open access: yes, 2007
In this thesis, I have described the work carried out on a single protein called RHAU, dealing with aspects of protein localization in cells, the regulation of global gene expression by different mechanisms, and cellular stress-responses.
Iwamoto, Fumiko
core   +1 more source

Dynamics and Conformations of a Full-Length CRESS-DNA Replicase

open access: yesViruses, 2023
Circular Rep-encoding single-stranded DNA (CRESS-DNA) viruses encode for a Replicase (Rep) that is essential for viral replication. Rep is a helicase with three domains: an endonuclease, an oligomeric, and an ATPase domain (ED, OD, and AD).
Elvira Tarasova, Reza Khayat
doaj   +1 more source

Interaction and assembly of the DNA replication core proteins of Kaposi’s sarcoma-associated herpesvirus

open access: yesMicrobiology Spectrum, 2023
Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes six highly conserved core replication proteins essential for the viral lytic DNA synthesis, including ORF6 (single-stranded DNA-binding protein), ORF9 (DNA polymerase), ORF40/41 (primase-associated ...
Lee-Wen Chen   +7 more
doaj   +1 more source

Helicase binding to DnaI exposes a cryptic DNA-binding site during helicase loading in Bacillus subtilis [PDF]

open access: yes, 1981
The Bacillus subtilis DnaI, DnaB and DnaD proteins load the replicative ring helicase DnaC onto DNA during priming of DNA replication. Here we show that DnaI consists of a C-terminal domain (Cd) with ATPase and DNA-binding activities and an N-terminal ...
Shi, Wei   +999 more
core   +49 more sources

p68 RNA helicase - identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts [PDF]

open access: yes, 2014
The human p68 protein is an RNA-dependent ATPase and RNA helicase which was first identified because of its immunological cross-reaction with a viral RNA helicase, simian virus 40 large T antigen.
Jamieson, DJ   +5 more
core   +2 more sources

The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus [PDF]

open access: yes, 2011
The human Suv3 helicase has been shown to be a major player in mitochondrial RNA surveillance and decay. In the present study we identify two new interaction partners of hSUV3: the RPA (replication protein A0 and FEN1 (flap endonuclease).
Stępień, Piotr P.   +2 more
core   +1 more source

Helicases and human diseases [PDF]

open access: yesFrontiers in Genetics, 2015
Recent progress in pharmaceutical sciences has made it possible for us to live longer and longer. For example, antibiotics and vaccines have been developed that were successfully administered to patients with infectious diseases. A number of effective drugs for specific diseases could be purified from natural resources or created by chemical synthesis,
Uchiumi, Fumiaki   +2 more
openaire   +3 more sources

The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway [PDF]

open access: yes, 2010
Xeroderma pigmentosum factor D (XPD) is a 5'-3' superfamily 2 helicase and the founding member of a family of DNA helicases with iron-sulphur cluster domains.
Rouillon, Christophe   +3 more
core   +1 more source

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