Results 51 to 60 of about 8,858 (210)

Discordance Between 16S rRNA Similarity and Genome‐Based Species Boundaries in Gluconobacter

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
16S rRNA sequences in Gluconobacter show high conservation with overlapping intra‐ and interspecific similarities, limiting species‐level resolution. In contrast, genome‐based ANI reveals clear divergence and distinct lineages, highlighting a fundamental discordance between 16S rRNA sequence‐based classification and genome‐level relationships ...
Shintaro Maeno, Naoya Kataoka, Minenosuke Matsutani, Toshiharu Yakushi   +3 more
wiley   +1 more source

Re-wiring of energy metabolism promotes viability during hyperreplication stress in E. coli. [PDF]

PLoS Genetics, 2017
Chromosome replication in Escherichia coli is initiated by DnaA. DnaA binds ATP which is essential for formation of a DnaA-oriC nucleoprotein complex that promotes strand opening, helicase loading and replisome assembly.
Godefroid Charbon, Christopher Campion, Siu Hung Joshua Chan, Louise Bjørn, Allan Weimann, Luís Cláudio Nascimento da Silva, Peter Ruhdal Jensen, Anders Løbner-Olesen   +7 more
doaj   +1 more source

The Safety of Interferon‐Based Therapies in Chronic Hepatitis B Patients With Compensatory Cirrhosis

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 107-116, June 2026.
While nucleos(t)ide analog (Nuc) therapy is the standard for chronic hepatitis B, pegylated interferon‐alpha (Peg‐IFN‐α) provides unique advantages, including finite treatment duration and long‐term benefits. However, its use in patients with compensated cirrhosis remains limited due to persistent safety concerns about potential decompensation and ...
Qiran Zhang, Taoran Geng, Ruirui You, Huiling Xiang, Ying Guo, Xiaohong Gao, Guojun Li, Qun Zhang, Xiaoping Wu, Haifang Cao, Wenhua Zhang, Jia Shang, Jiawei Geng, Lihong Qu, Shuilin Sun, Xiulan Xue, Rui Zhao, Lihua Zhong, Guohong Ge, Yanbin Wang, Jianqi Lian, Ming Liang, Qing Ye, Xiaoyan Wang, Xiaoqing Guo, Dan Xu, Yiqi Yu, Feng Sun, Chao Qiu, Jiming Zhang, Yuxian Huang, Wenhong Zhang, Xiaolong Qi   +32 more
wiley   +1 more source

A Structural Basis for the Regulatory Inactivation of DnaA [PDF]

Journal of Molecular Biology, 2009
Regulatory inactivation of DnaA is dependent on Hda (homologous to DnaA), a protein homologous to the AAA+ (ATPases associated with diverse cellular activities) ATPase region of the replication initiator DnaA. When bound to the sliding clamp loaded onto duplex DNA, Hda can stimulate the transformation of active DnaA-ATP into inactive DnaA-ADP.
Qingping, Xu, Daniel, McMullan, Polat, Abdubek, Tamara, Astakhova, Dennis, Carlton, Connie, Chen, Hsiu-Ju, Chiu, Thomas, Clayton, Debanu, Das, Marc C, Deller, Lian, Duan, Marc-Andre, Elsliger, Julie, Feuerhelm, Joanna, Hale, Gye Won, Han, Lukasz, Jaroszewski, Kevin K, Jin, Hope A, Johnson, Heath E, Klock, Mark W, Knuth, Piotr, Kozbial, S, Sri Krishna, Abhinav, Kumar, David, Marciano, Mitchell D, Miller, Andrew T, Morse, Edward, Nigoghossian, Amanda, Nopakun, Linda, Okach, Silvya, Oommachen, Jessica, Paulsen, Christina, Puckett, Ron, Reyes, Christopher L, Rife, Natasha, Sefcovic, Christine, Trame, Henry, van den Bedem, Dana, Weekes, Keith O, Hodgson, John, Wooley, Ashley M, Deacon, Adam, Godzik, Scott A, Lesley, Ian A, Wilson   +43 more
openaire   +2 more sources

Relative DNA binding by ATP-DnaA-his compared to ADP-DnaA-his.

, 2015
(A) The ratio of the amount of DNA recovered bound to ATP-DnaA-his vs. ADP-DnaA-his is plotted versus the DnaA concentration. Background binding was subtracted prior to calculating the ratio.
Alan D. Grossman (237649), Janet L. Smith (213446)   +1 more
core   +1 more source

AdpA, key regulator for morphological differentiation regulates bacterial chromosome replication [PDF]

Open Biology, 2012
AdpA, one of the most pleiotropic transcription regulators in bacteria, controls expression of several dozen genes during Streptomyces differentiation.
Marcin Wolański, Dagmara Jakimowicz, Jolanta Zakrzewska-Czerwińska   +2 more
doaj   +1 more source

Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Minimal bacterial cells such as JCVI‐Syn3A provide a powerful system for uncovering the essential mechanisms of chromosome organization and segregation. Lacking canonical systems such as Min and ParABS, JCVI‐Syn3A relies primarily on structural maintenance of chromosomes (SMC) protein complexes for partitioning.
Andrew K. Maytin, Benjamin R. Gilbert, Zaida Luthey‐Schulten   +2 more
wiley   +1 more source

DnaA concentrations in DnaA overproducing cells, ΔdatA cells and DiaA overproducing cells.

, 2015
1) ng DnaA per μg cell extract. The numbers are relative to the wild type or wild type containing the empty plasmid. Measured by imunoblotting.± represents the standard deviationDnaA concentrations in DnaA overproducing cells, ΔdatA cells and DiaA ...
Riikka Taipale (750567), Silje Martinsen (750568), Kirsten Skarstad (183763), Solveig Fossum-Raunehaug (647783), Ingvild Flåtten (183759)   +4 more
core   +1 more source

Droplet Encoding‐Pairing Enabled Multiplexed Digital Loop‐Mediated Isothermal Amplification for Simultaneous Quantitative Detection of Multiple Pathogens

Advanced Science, 2023
Despite the advantages of digital nucleic acid analysis (DNAA) in terms of sensitivity, precision, and resolution, current DNAA methods commonly suffer a limitation in multiplexing capacity.
Dongyang Cai, Yu Wang, Jingjing Zou, Zhujun Li, Enqi Huang, Xiuyun Ouyang, Zhiquan Que, Yanzhang Luo, Zhenhua Chen, Yanqing Jiang, Guohao Zhang, Hongkai Wu, Dayu Liu   +12 more
doaj   +1 more source

Third Generation Genome Sequencing of the Endobacterium Corynebacterium kroppenstedtii subsp. demodicis Reveals Details of Its Microbe‐Host‐Interaction With the Most Complex Human Commensal, Demodex folliculorum

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
The symbiotic interaction between Demodex folliculorum and Corynebacterium kroppenstedtii subsp. demodicis. Created by the author based on genomic and functional analyses presented in this work. The tripartite interaction between the human host, the mite Demodex folliculorum, and its endosymbiont Corynebacterium kroppenstedtii subsp. demodicis.
T. Steegmüller, S. Walch, S. Gschwendtner, A. Klingl, L. E. French, M. Flaig, B. M. Clanner‐Engelshofen   +6 more
wiley   +1 more source