Positive and Negative Regulation of DNA Replication Initiation. [PDF]
Trends Genet, 2020 Ding Q, Koren A.
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Initiation of DNA Replication [PDF]
EcoSal Plus, 2010 In recent years it has become clear that complex regulatory circuits control the initiation step of DNA replication by directing the assembly of a multicomponent molecular machine (the orisome) that separates DNA strands and loads replicative helicase at oriC , the unique chromosomal origin of replication.
Alan C, Leonard, Julia E, Grimwade
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Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle. [PDF]
PLoS Genetics, 2013 Mammalian DNA replication starts at distinct chromosomal sites in a tissue-specific pattern coordinated with transcription, but previous studies have not yet identified a chromatin modification that correlates with the initiation of DNA replication at ...
Haiqing Fu +9 more
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Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication
eLife, 2020 DNA replication is needed to duplicate a cell’s genome in S phase and segregate it during cell division. Previous work in Leishmania detected DNA replication initiation at just a single region in each chromosome, an organisation predicted to be ...
Jeziel Dener Damasceno +7 more
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Loss of Ezh2 function remodels the DNA replication initiation landscape
Cell Reports, 2023 Summary: In metazoan cells, DNA replication initiates from thousands of genomic loci scattered throughout the genome called DNA replication origins. Origins are strongly associated with euchromatin, particularly open genomic regions such as promoters and
Paulina Prorok +6 more
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Control of Eukaryotic DNA Replication Initiation-Mechanisms to Ensure Smooth Transitions. [PDF]
Genes (Basel), 2019 Reusswig KU, Pfander B.
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What influences DNA replication rate in budding yeast? [PDF]
PLoS ONE, 2010 BACKGROUND: DNA replication begins at specific locations called replication origins, where helicase and polymerase act in concert to unwind and process the single DNA filaments. The sites of active DNA synthesis are called replication forks.
Thomas W Spiesser +3 more
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A NuRD Complex from Xenopus laevis Eggs Is Essential for DNA Replication during Early Embryogenesis
Cell Reports, 2018 Summary: DNA replication in the embryo of Xenopus laevis changes dramatically at the mid-blastula transition (MBT), with Y RNA-independent random initiation switching to Y RNA-dependent initiation at specific origins.
Christo P. Christov +6 more
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A genetic screen for replication initiation defective (
Cell Division, 2010 In fission yeast the intra-S phase and DNA damage checkpoints are activated in response to inhibition of DNA replication or DNA damage, respectively. The intra-S phase checkpoint responds to stalled replication forks leading to the activation of the Cds1
Locovei Alexandra M +2 more
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The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells
Nature Communications, 2022 DNA polymerase epsilon has a critical role in DNA replication initiation. Here, the authors show that in human cancer cells POLE is dispensable for the replicative helicase assembly but not for replication initiation, which requires the non-catalytic ...
Sameera Vipat +5 more
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