Results 41 to 50 of about 1,092,520 (246)

GEMC1, a novel factor required for chromosomal DNA replication [PDF]

, 2009
In eukaryotic cells DNA replication begins from multiple origins. During the process of initiation, the DNA replication fork is established at each origin. In lower eukaryotes many factors required for chromosomal DNA replication have been identified.
Balestrini, A.
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Influence of retinoblastoma-related gene silencing on the initiation of DNA replication by African cassava mosaic virus Rep in cells of mature leaves in Nicotiana benthamiana plants [PDF]

, 2011
Background Geminiviruses mainly infect terminally differentiated tissues and cells in plants. They need to reprogramme host cellular machinery for DNA replication.
Yule Liu, Bruce, Gareth, Bruce Gareth, Liu, Yule, Liu Yule, Gareth Bruce, Nongnong Shi, Gu, Mei, Hong, Yiguo, Shi Nongnong, Yiguo Hong, Gu Mei, Shi, Nongnong, Hong Yiguo, Mei Gu   +14 more
core   +1 more source

Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

eLife
Robust control of DNA replication is fundamental to bacterial proliferation. In Escherichia coli, replication initiation is thought to be regulated by oscillations in DnaA activity, driven by DnaA-chromosome interactions that differ among leading models.
Dengjin Li, Hai Zheng, Yang Bai, Zheng Zhang, Hao Cheng, Xiongliang Huang, Ting Wei, Matthew Chang, Arieh Zaritsky, Terence Hwa, Chenli Liu   +10 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Human GINS, a conserved DNA replication factor and candidate cancer marker [PDF]

, 2011
The GINS complex (a heterotetramer of Sld5, Psf1, Psf2 and Psf3) is a highly conserved DNA replication factor required for the initiation and elongation of DNA replication. GINS is believed to associate with Cdc45 and MCM proteins on replicating DNA. The

core   +2 more sources

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1

Cell Reports, 2017
Dbf4-dependent kinases (DDKs) are required for the initiation of DNA replication, their essential targets being the MCM2-7 proteins. We show that, in Xenopus laevis egg extracts and human cells, hyper-phosphorylation of DNA-bound Mcm4, but not ...
Robert C. Alver, Gaganmeet Singh Chadha, Peter J. Gillespie, J. Julian Blow   +3 more
doaj   +1 more source

Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

eLife, 2021
Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, replication timing, and fork ...
Nina Kirstein, Alexander Buschle, Xia Wu, Stefan Krebs, Helmut Blum, Elisabeth Kremmer, Ina M Vorberg, Wolfgang Hammerschmidt, Laurent Lacroix, Olivier Hyrien, Benjamin Audit, Aloys Schepers   +11 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

DNA replication licensing in somatic and germ cells [PDF]

, 2004
The DNA replication (or origin) licensing system ensures precise duplication of the genome in each cell cycle and is a powerful regulator of cell proliferation in metazoa.
Williams, C, Jung, Hyo-Il, Obermann, EC, Ellen C. Obermann, Kai Stoeber, Loddo, Marco, Kathryn Leigh Eward, Marco Loddo, Shreeram, S, Williams, GH, Obermann, Ellen C, Hyo-Il Jung, Williams, Craig, J. Julian Blow, Gareth H. Williams, Eward, Kathryn Leigh, Fanshawe, Thomas, Jung, HI, Shreeram, S., Prevost, Toby; id_orcid, Blow, J. Julian; id_orcid, A. Toby Prevost, Loddo, M, Williams, Gareth H., Thomas Fanshawe, Fanshawe, T, Obermann, Ellen C., Eward, KL, Williams, Gareth H, Jung, H-I, S. Shreeram, Blow, J Julian, Prevost, A. Toby, Stoeber, K, Stoeber, Kai, Blow, J. Julian, Prevost, AT, Blow, JJ, Craig Williams   +38 more
core   +1 more source