Results 51 to 60 of about 1,088,807 (293)

High-Resolution Replication Profiles Define the Stochastic Nature of Genome Replication Initiation and Termination [PDF]

, 2013
Copyright © 2013 The Authors. Published by Elsevier Inc.
Nieduszynski, Conrad A, Tanaka, Tomoyuki U.; id_orcid, de Moura, Alessandro P. S., Tanaka, Tomoyuki U., Saner, Nazan, de Moura, Alessandro P S, Nieduszynski, Conrad A., deMoura, Alessandro P. S., Hawkins, Michelle, Renata Retkute, Müller, Carolin A, Tanaka, Tomoyuki U, Alessandro P.S. de Moura, Tomoyuki U. Tanaka, Michelle Hawkins, M�ller, Carolin A., Müller, Carolin A., de Moura, Alessandro P.S., Carolin A. Müller, Nazan Saner, Retkute, Renata, Conrad A. Nieduszynski   +21 more
core   +1 more source

The essential role of the 3' terminal template base in the first steps of protein-primed DNA replication. [PDF]

PLoS ONE, 2012
Bacteriophages ϕ29 and Nf from Bacillus subtilis start replication of their linear genomes at both ends using a protein-primed mechanism by means of which the DNA polymerase initiates replication by adding dAMP to the terminal protein, this insertion ...
Irene Rodríguez, Elisa Longás, Miguel de Vega, Margarita Salas   +3 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

GEMC1, a novel factor required for chromosomal DNA replication [PDF]

, 2009
In eukaryotic cells DNA replication begins from multiple origins. During the process of initiation, the DNA replication fork is established at each origin. In lower eukaryotes many factors required for chromosomal DNA replication have been identified.
Balestrini, A.
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A structural view of the initiators for chromosome replication [PDF]

Current Opinion in Structural Biology, 2018
Propagation of genetic material is central to the survival and fitness of multicellular organisms. To efficiently duplicate eukaryotic genomes of sizes between ~107 bp (yeast) to ~1011 bp (plants), replication initiates from multiple start sites called “replication origins” distributed on multiple chromosomes [1].
Kin Fan, On, Matt, Jaremko, Bruce, Stillman, Leemor, Joshua-Tor   +3 more
openaire   +2 more sources

Influence of retinoblastoma-related gene silencing on the initiation of DNA replication by African cassava mosaic virus Rep in cells of mature leaves in Nicotiana benthamiana plants [PDF]

, 2011
Background Geminiviruses mainly infect terminally differentiated tissues and cells in plants. They need to reprogramme host cellular machinery for DNA replication.
Yule Liu, Bruce, Gareth, Bruce Gareth, Liu, Yule, Liu Yule, Gareth Bruce, Nongnong Shi, Gu, Mei, Hong, Yiguo, Shi Nongnong, Yiguo Hong, Gu Mei, Shi, Nongnong, Hong Yiguo, Mei Gu   +14 more
core   +1 more source

Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

eLife
Robust control of DNA replication is fundamental to bacterial proliferation. In Escherichia coli, replication initiation is thought to be regulated by oscillations in DnaA activity, driven by DnaA-chromosome interactions that differ among leading models.
Dengjin Li, Hai Zheng, Yang Bai, Zheng Zhang, Hao Cheng, Xiongliang Huang, Ting Wei, Matthew Chang, Arieh Zaritsky, Terence Hwa, Chenli Liu   +10 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Human GINS, a conserved DNA replication factor and candidate cancer marker [PDF]

, 2011
The GINS complex (a heterotetramer of Sld5, Psf1, Psf2 and Psf3) is a highly conserved DNA replication factor required for the initiation and elongation of DNA replication. GINS is believed to associate with Cdc45 and MCM proteins on replicating DNA. The

core   +2 more sources