Results 21 to 30 of about 1,092,520 (246)

Universal temporal profile of replication origin activation in eukaryotes. [PDF]

PLoS ONE, 2009
Although replication proteins are conserved among eukaryotes, the sequence requirements for replication initiation differ between species. In all species, however, replication origins fire asynchronously throughout S phase. The temporal program of origin
Arach Goldar, Marie-Claude Marsolier-Kergoat, Olivier Hyrien   +2 more
doaj   +1 more source

Genome organization of DNA replication timing and its link to chromatin and transcription [PDF]

, 2008
The replication of the genome is a highly organized process. Not every sequence replicates at the same time, instead some genes replicate early, while others replicate later during S phase.
Schwaiger, Michaela
core   +1 more source

Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels [PDF]

, 2010
In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in
Blow, J. Julian; id_orcid, Thomson, Alexander M., Gillespie, Peter J., Peter J. Gillespie, J. Julian Blow, Blow, J. Julian, Alexander M. Thomson   +6 more
core   +1 more source

Single molecule analysis of replicated DNA reveals the usage of multiple KSHV genome regions for latent replication. [PDF]

PLoS Pathogens, 2011
Kaposi's sarcoma associated herpesvirus (KSHV), an etiologic agent of Kaposi's sarcoma, Body Cavity Based Lymphoma and Multicentric Castleman's Disease, establishes lifelong latency in infected cells.
Subhash C Verma, Jie Lu, Qiliang Cai, Settapong Kosiyatrakul, Maria E McDowell, Carl L Schildkraut, Erle S Robertson   +6 more
doaj   +1 more source

Molecular Architecture of the DNA Replication Origin Activation Checkpoint [PDF]

, 2010
Perturbation of DNA replication initiation arrests human cells in G1, pointing towards an origin activation checkpoint. We used RNAi against Cdc7 kinase to inhibit replication initiation and dissect this checkpoint in fibroblasts.
Claire Mulvey, Slavica Tudzarova, Kai Stoeber, Tudzarova, S, Mulvey, C, Godovac-Zimmermann, J, Wollenschlager, A, Jasminka Godovac-Zimmermann, Matthew W B Trotter, Alex Wollenschlaeger, Stoeber, K, Gareth H Williams, Trotter, MWB, Williams, G   +13 more
core   +1 more source

A NuRD Complex from Xenopus laevis Eggs Is Essential for DNA Replication during Early Embryogenesis

Cell Reports, 2018
Summary: DNA replication in the embryo of Xenopus laevis changes dramatically at the mid-blastula transition (MBT), with Y RNA-independent random initiation switching to Y RNA-dependent initiation at specific origins.
Christo P. Christov, Kevin S. Dingwell, Mark Skehel, Helen S. Wilkes, Julian E. Sale, James C. Smith, Torsten Krude   +6 more
doaj   +1 more source

Genome-wide hierarchy of replication origin usage in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2006
Replication origins in a genome are inherently different in their base sequence and in their response to temporal and cell cycle regulation signals for DNA replication.
Justin J Donato, Shau Chee C Chung, Bik K Tye   +2 more
doaj   +1 more source

Identification of 1600 replication origins in S. cerevisiae

eLife
There are approximately 500 known origins of replication in the yeast genome, and the process by which DNA replication initiates at these locations is well understood.
Eric J Foss, Carmina Lichauco, Tonibelle Gatbonton-Schwager, Sara J Gonske, Brandon Lofts, Uyen Lao, Antonio Bedalov   +6 more
doaj   +1 more source

Global early replication disrupts gene expression and chromatin conformation in a single cell cycle

Genome Biology, 2022
Background The early embryonic divisions of many organisms, including fish, flies, and frogs, are characterized by a very rapid S-phase caused by high rates of replication initiation.
Miguel M. Santos, Mark C. Johnson, Lukáš Fiedler, Philip Zegerman   +3 more
doaj   +1 more source

Loss of Ezh2 function remodels the DNA replication initiation landscape

Cell Reports, 2023
Summary: In metazoan cells, DNA replication initiates from thousands of genomic loci scattered throughout the genome called DNA replication origins. Origins are strongly associated with euchromatin, particularly open genomic regions such as promoters and
Paulina Prorok, Faezeh Forouzanfar, Nerea Murugarren, Isabelle Peiffer, Romain Charton, Ildem Akerman, Marcel Méchali   +6 more
doaj   +1 more source