Universal temporal profile of replication origin activation in eukaryotes. [PDF]
PLoS ONE, 2009 Although replication proteins are conserved among eukaryotes, the sequence requirements for replication initiation differ between species. In all species, however, replication origins fire asynchronously throughout S phase. The temporal program of origin
Arach Goldar +2 more
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Single molecule analysis of replicated DNA reveals the usage of multiple KSHV genome regions for latent replication. [PDF]
PLoS Pathogens, 2011 Kaposi's sarcoma associated herpesvirus (KSHV), an etiologic agent of Kaposi's sarcoma, Body Cavity Based Lymphoma and Multicentric Castleman's Disease, establishes lifelong latency in infected cells.
Subhash C Verma +6 more
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A NuRD Complex from Xenopus laevis Eggs Is Essential for DNA Replication during Early Embryogenesis
Cell Reports, 2018 Summary: DNA replication in the embryo of Xenopus laevis changes dramatically at the mid-blastula transition (MBT), with Y RNA-independent random initiation switching to Y RNA-dependent initiation at specific origins.
Christo P. Christov +6 more
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Genome-wide hierarchy of replication origin usage in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2006 Replication origins in a genome are inherently different in their base sequence and in their response to temporal and cell cycle regulation signals for DNA replication.
Justin J Donato +2 more
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Identification of 1600 replication origins in S. cerevisiae
eLifeThere are approximately 500 known origins of replication in the yeast genome, and the process by which DNA replication initiates at these locations is well understood.
Eric J Foss +6 more
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Loss of Ezh2 function remodels the DNA replication initiation landscape
Cell Reports, 2023 Summary: In metazoan cells, DNA replication initiates from thousands of genomic loci scattered throughout the genome called DNA replication origins. Origins are strongly associated with euchromatin, particularly open genomic regions such as promoters and
Paulina Prorok +6 more
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Global early replication disrupts gene expression and chromatin conformation in a single cell cycle
Genome Biology, 2022 Background The early embryonic divisions of many organisms, including fish, flies, and frogs, are characterized by a very rapid S-phase caused by high rates of replication initiation.
Miguel M. Santos +3 more
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A genetic screen for replication initiation defective (
Cell Division, 2010 In fission yeast the intra-S phase and DNA damage checkpoints are activated in response to inhibition of DNA replication or DNA damage, respectively. The intra-S phase checkpoint responds to stalled replication forks leading to the activation of the Cds1
Locovei Alexandra M +2 more
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Plasticity of DNA replication initiation in Epstein-Barr virus episomes. [PDF]
PLoS Biology, 2004 In mammalian cells, the activity of the sites of initiation of DNA replication appears to be influenced epigenetically, but this regulation is not fully understood.
Paolo Norio, Carl L Schildkraut
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source