Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]
, 2010 Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Sercombe, Heather E +3 more
core +4 more sources
Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts [PDF]
, 2013 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) has a well-established role in epigenetic regulation through the recognition of various histone marks and interaction with chromatin-modifying proteins.
Taylor, Elaine +3 more
core +4 more sources
Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle. [PDF]
PLoS Genetics, 2013 Mammalian DNA replication starts at distinct chromosomal sites in a tissue-specific pattern coordinated with transcription, but previous studies have not yet identified a chromatin modification that correlates with the initiation of DNA replication at ...
Haiqing Fu +9 more
doaj +1 more source
Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements. [PDF]
PLoS Genetics, 2014 Eukaryotic cells must inhibit re-initiation of DNA replication at each of the thousands of origins in their genome because re-initiation can generate genomic alterations with extraordinary frequency.
Christopher D Richardson, Joachim J Li
doaj +1 more source
A Dynamic Stochastic Model for DNA Replication Initiation in Early Embryos [PDF]
, 2008 Background: Eukaryotic cells seem unable to monitor replication completion during normal S phase, yet must ensure a reliable replication completion time.
Labit, H +7 more
core +2 more sources
The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans
Biology, 2023 Understanding human DNA replication through the study of yeast has been an extremely fruitful journey. The minichromosome maintenance (MCM) 2–7 genes that encode the catalytic core of the eukaryotic replisome were initially identified through forward ...
Bik-Kwoon Tye, Yuanliang Zhai
doaj +1 more source
Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication
eLife, 2020 DNA replication is needed to duplicate a cell’s genome in S phase and segregate it during cell division. Previous work in Leishmania detected DNA replication initiation at just a single region in each chromosome, an organisation predicted to be ...
Jeziel Dener Damasceno +7 more
doaj +1 more source
mBio, 2019 The stringent response enables bacteria to respond to a variety of environmental stresses, especially various forms of nutrient limitation. During the stringent response, the cell produces large quantities of the nucleotide alarmone ppGpp, which ...
James A. Kraemer +2 more
doaj +1 more source
The Fis protein has a stimulating role in initiation of replication in Escherichia coli in vivo. [PDF]
PLoS ONE, 2013 The Fis protein is a nucleoid associated protein that has previously been reported to act negatively in initiation of replication in Escherichia coli.
Ingvild Flåtten, Kirsten Skarstad
doaj +1 more source
Genome-wide analysis reveals extensive functional interaction between DNA replication initiation and transcription in the genome of trypanosoma brucei [PDF]
, 2012 Identification of replication initiation sites, termed origins, is a crucial step in understanding genome transmission in any organism. Transcription of the Trypanosoma brucei genome is highly unusual, with each chromosome comprising a few discrete ...
Dickens, N.J. +45 more
core +1 more source