Mechanistic studies of initiator-initiator interaction and replication initiation [PDF]
The EMBO Journal, 1998 Unlike the chromosome of Escherichia coli that needs only one replication initiator protein (origin recognition protein) called DnaA, many plasmid replicons require dual initiators: host-encoded DnaA and a plasmid-encoded origin recognition protein, which is believed to be the major determinant of replication control. Hitherto, the relative mechanistic
Y B, Lu, H J, Datta, D, Bastia
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Transcription shapes DNA replication initiation to preserve genome integrity
Genome Biology, 2021 Background Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage.
Yang Liu +10 more
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The Role of MTBP as a Replication Origin Firing Factor
Biology, 2022 The initiation step of replication at replication origins determines when and where in the genome replication machines, replisomes, are generated. Tight control of replication initiation helps facilitate the two main tasks of genome replication, to ...
Eman Zaffar +3 more
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Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle. [PDF]
PLoS Genetics, 2013 Mammalian DNA replication starts at distinct chromosomal sites in a tissue-specific pattern coordinated with transcription, but previous studies have not yet identified a chromatin modification that correlates with the initiation of DNA replication at ...
Haiqing Fu +9 more
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Replication Initiation in Bacteria [PDF]
, 2016 The initiation of chromosomal DNA replication starts at a replication origin, which in bacteria is a discrete locus that contains DNA sequence motifs recognized by an initiator protein whose role is to assemble the replication fork machinery at this site.
S, Chodavarapu, J M, Kaguni
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Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements. [PDF]
PLoS Genetics, 2014 Eukaryotic cells must inhibit re-initiation of DNA replication at each of the thousands of origins in their genome because re-initiation can generate genomic alterations with extraordinary frequency.
Christopher D Richardson, Joachim J Li
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The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans
Biology, 2023 Understanding human DNA replication through the study of yeast has been an extremely fruitful journey. The minichromosome maintenance (MCM) 2–7 genes that encode the catalytic core of the eukaryotic replisome were initially identified through forward ...
Bik-Kwoon Tye, Yuanliang Zhai
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mBio, 2019 The stringent response enables bacteria to respond to a variety of environmental stresses, especially various forms of nutrient limitation. During the stringent response, the cell produces large quantities of the nucleotide alarmone ppGpp, which ...
James A. Kraemer +2 more
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Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication
eLife, 2020 DNA replication is needed to duplicate a cell’s genome in S phase and segregate it during cell division. Previous work in Leishmania detected DNA replication initiation at just a single region in each chromosome, an organisation predicted to be ...
Jeziel Dener Damasceno +7 more
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The Fis protein has a stimulating role in initiation of replication in Escherichia coli in vivo. [PDF]
PLoS ONE, 2013 The Fis protein is a nucleoid associated protein that has previously been reported to act negatively in initiation of replication in Escherichia coli.
Ingvild Flåtten, Kirsten Skarstad
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