Results 81 to 90 of about 3,588,418 (239)
PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity
Virology, 2015 Porcine reproductive and respiratory disease virus (PRRSV) has the intrinsic ability to adapt and evolve. After 25 years of study, this persistent pathogen has continued to frustrate efforts to eliminate infection of herds through vaccination or other ...
M. Kappes, K. Faaberg
semanticscholar +1 more source
The enhancement of M13 phage titration by optimizing the origin of replication
Research in Pharmaceutical SciencesBackground and purpose: M13KO7, a modified M13 phage variant, carries the p15A replication origin and Tn903 kanamycin resistance gene. This study aimed to optimize M13KO7's replication by substituting the p15A origin with the higher-copy pMB1 origin (500-
Mohammad Hossein Darvishali +2 more
doaj +1 more source
Molecules and Cells, 2015 Chromosomes of a broad range of species, from bacteria to mammals, are structured by large topological domains whose precise functional roles and regulatory mechanisms remain elusive.
M. Marbouty +9 more
semanticscholar +1 more source
Kinetic model of DNA replication in eukaryotic organisms
, 2003 We formulate a kinetic model of DNA replication that quantitatively describes recent results on DNA replication in the in vitro system of Xenopus laevis prior to the mid-blastula transition.
Avrami +47 more
core +1 more source
Interpreting the dependence of mutation rates on age and time [PDF]
, 2015 Mutations can arise from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell divisions, providing
Gao, Ziyue +3 more
core +5 more sources
Mapping replication origins [PDF]
Genome Biology, 2000 A new technique for the selection of newly synthesized DNA has enabled the selection and amplification of putative origins of replication on the human X chromosome.
openaire +1 more source
Genetic Variation Meets Replication Origins [PDF]
Cell, 2014 Genome replication programs are highly orchestrated. In this issue, Koren and colleagues leverage whole-genome sequencing data to discover that DNA replication timing patterns differ between individuals and are associated with genetic variants. These so-called rtQTLs represent a new form of quantitative trait loci that may influence gene dosage and ...
Hause, Ronald J., Shendure, Jay
openaire +2 more sources
A hybrid bacterial replication origin [PDF]
EMBO reports, 2001 We constructed a hybrid replication origin that consists of the main part of oriC from Escherichia coli, the DnaA box region and the AT‐rich region from Bacillus subtilis oriC. The AT‐rich region could be unwound by E. coli DnaA protein, and the DnaB helicase was loaded into the single‐stranded bubble.
H, Seitz, M, Welzeck, W, Messer
openaire +2 more sources
Mcm10 interacts with Rad4/Cut5(TopBP1) and its association with origins of DNA replication is dependent on Rad4/Cut5(TopBP1). [PDF]
, 2011 © Elsevier, 2011. This is a post-print version of the article. The definitive version is available from: http://www.sciencedirect.com/science/article/pii/S1568786411002369. Deposited in accordance with SHERPA RoMEO guidelinesInitiation of DNA replication
Aves, Stephen +4 more
core +1 more source
Functional characterization of the origin of replication of pRN1 from Sulfolobus islandicus REN1H1. [PDF]
PLoS ONE, 2013 Plasmid pRN1 from Sulfolobus islandicus REN1H1 is believed to replicate by a rolling circle mechanism but its origin and mechanism of replication are not well understood.
Chijioke J Joshua +2 more
doaj +1 more source