Results 101 to 110 of about 2,339,539 (318)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pocket Statistics 2010

, 2010
A compact selection of statistics on the social security programmes administered by the Kela. Including both tables and charts, the Pocket statistics presents key data on the benefits provided by the Kela, supplemented by selected data about programmes ...
Kela
core  

2022-2023 AAAL Statistics

Annual institutional statistics collection for AAAL member libraries.
Statistics, AAAL
core   +1 more source

VIRTUAL LABORATORY BASED ON INGENHOUSZ EXPERIMENT MODELING: ENHANCING CONCEPTUAL UNDERSTANDING AND SCIENTIFIC LITERACY

Jurnal Eduscience
Purpose – This study aims to evaluate the effectiveness of the Ingenhousz Experiment Virtual Laboratory, integrated with the GENIUS syntax, within a Blended Learning framework to accelerate students' conceptual understanding and science literacy in ...
Adnan Adnan, Syamsiah Syamsiah, Dian Aswita, Nur Hikmah, Nur Risnawati Kusuma, Sahla Sahira, Muh Yunus   +6 more
doaj   +1 more source

Mendelian randomization study shows a causal effect of asthma on chronic obstructive pulmonary disease risk

PLoS ONE, 2023
Background This study was performed to explore the causal association between asthma and chronic obstructive pulmonary disease(COPD). Methods We obtained summary statistics for asthma from 408,442 Europeans in an open genome-wide association study (GWAS)
Yuanyuan Li, Weina Wang, Dengfeng Zhou, Qiaofa Lu, Lili Li, Bo Zhang   +5 more
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

2024-2025 AAAL Statistics

Annual institutional statistics collection for AAAL member ...
Statistics, AAAL
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Department of Applied Mathematics and Statistics newsletter, September 11, 2023

, 2023
Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...

core  

Federal minimum wage hikes do reduce teenage employment. A replication study of Bazen & Marimoutou (Oxford Bulletin of Economics and Statistics, 2002)

International Journal for Re-Views in Empirical Economics, 2018
In 2002 we published a paper in which we used state space time series methods to analyse the teenage employment-federal minimum wage relationship in the US (Bazen and Marimoutou, 2002).The study used quarterly data for the 46 year period running from ...
Velayoudom Marimoutou, Stephen Bazen
doaj   +1 more source