Results 131 to 140 of about 430,384 (331)

Using Large Language Models to Create AI Personas for Replication and Prediction of Media Effects: An Empirical Test of 133 Published Experimental Research Findings [PDF]

open access: yesarXiv
This report analyzes the potential for large language models (LLMs) to expedite accurate replication of published message effects studies. We tested LLM-powered participants (personas) by replicating 133 experimental findings from 14 papers containing 45 recent studies in the Journal of Marketing (January 2023-May 2024).
arxiv  

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

open access: yesFEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu   +6 more
wiley   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

open access: yesFEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu   +6 more
wiley   +1 more source

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

open access: yesFEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu   +4 more
wiley   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

open access: yesFEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel   +3 more
wiley   +1 more source

Building access to linked data for program evaluation: lessons and opportunities from the evaluation of a pan-Canadian skills training initiative

open access: yesInternational Journal of Population Data Science
In recent years, Canada’s statistical agency (Statistics Canada) has developed sophisticated linkage infrastructure through their Social Data Linkage Environment (SDLE), linking internal data sets held by Statistics Canada and external data held by ...
Max Palamar, Sandra Nkusi
doaj   +1 more source

Replicable Bandits for Digital Health Interventions [PDF]

open access: yesarXiv
Adaptive treatment assignment algorithms, such as bandit and reinforcement learning algorithms, are increasingly used in digital health intervention clinical trials. Causal inference and related data analyses are critical for evaluating digital health interventions, deciding how to refine the intervention, and deciding whether to roll-out the ...
arxiv  

Home - About - Disclaimer - Privacy