Results 221 to 230 of about 2,339,539 (318)

PCSK9 and Breast Cancer Survival: A Mendelian Randomization Study. [PDF]

Cancer Epidemiol Biomarkers Prev
Pott J, Mason AM, Salo V, Kettunen J, for FINNGEN, Burgess S.   +5 more
europepmc   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Department of Applied Mathematics and Statistics Newsletter, February 2, 2026

Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...

core  

Quantifying replication fidelity of unnatural base pairs using nanopore sequencing. [PDF]

Nat Commun
Kaplan NA, Sumabat JR, McKelvey JV, Lunshof JE, Marchand JA.   +4 more
europepmc   +1 more source

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

p38 Inhibitor SB203580 Inhibits HEV Infection and Prevents HEV-Related Adverse Pregnancy Outcomes in a Pregnant Rabbit Model. [PDF]

Liver Int
Li M, Wan W, Song Z, Wang P, Sun W, He Q, Zhou H.   +6 more
europepmc   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Infant respiratory syncytial virus and childhood asthma: a nationwide registry-based, sibling-controlled, and genome-wide association study. [PDF]

Lancet Reg Health Eur
Vartiainen P, Haapaniemi H, Lee Y, Magnus MC, Hartonen T, Detrois K, Viippola E, Ferro M, Laitinen T, FinnGen, Madsen MA, Ostrowski SR, Pedersen OB, Sørensen E, Erikstrup C, Gong T, Rhedin S, Lundholm C, Dallagiacoma G, Almqvist C, Egeskov-Cavling AM, Fischer TK, Pasanen A, Rämet M, Vuorinen AL, Hiekkalinna T, Håberg SE, Magnus P, Perola M, Jugessur A, Ganna A, Heinonen S.   +31 more
europepmc   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

The Genetic and Transcriptomic Nexus of Age-Related Hearing Loss and Alzheimer's Disease. [PDF]

Genes (Basel)
Deng K, Deng X, Li S, Fang S, Wei F.
europepmc   +1 more source