Results 121 to 130 of about 4,294,209 (341)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

INFLUENCE OF VIRAL REPLICATION MECHANISMS ON WITHIN-HOST EVOLUTIONARY DYNAMICS [PDF]

, 2012
Claude Loverdo, Miran Park, Sebastian J. Schreiber, James O. Lloyd‐Smith   +3 more
openalex   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

DYNAMIC ANALYSIS OF THE COOPERATION AND COMPETITION RELATIONSHIP IN THE OIL AND GAS INDUSTRY IN ROMANIA [PDF]

Oradea Journal of Business and Economics, 2019
The aim of the paper is to analyse the cooperation and competition relationship in the oil and gas industry in Romania using the game theory. The players are the companies, the payoffs are the profits obtained by the entities and there are two strategies
Doriana Andreea Rămescu, Nicoleta Sîrghi, Mihaela Neamțu   +2 more
doaj  

The Dynamics of Human Cytomegalovirus Replication in Vivo [PDF]

, 1999
Vincent C. Emery, Alethea Cope, E Frances Bowen, D. Gor, Paul Griffiths   +4 more
openalex   +1 more source

Cell-type specificity of the human mutation landscape with respect to DNA replication dynamics

, 2023
Madison Caballero, Dominik Boos, Amnon Koren   +2 more
openalex   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Genome replication dynamics of a bacteriophage and its satellite reveal strategies for parasitism and viral restriction [PDF]

, 2019
Zachary K. Barth, Tania V. Silvas, Angus Angermeyer, Kimberley D. Seed   +3 more
openalex   +1 more source

In vivo DNA replication dynamics unveil aging-dependent replication stress

Cell
The genome duplication program is affected by multiple factors in vivo, including developmental cues, genotoxic stress, and aging. Here, we monitored DNA replication initiation dynamics in regenerating livers of young and old mice after partial hepatectomy to investigate the impact of aging. In young mice, the origin firing sites were well defined; the
Rossetti, Giacomo G, Dommann, Noëlle Annick, Karamichali, Angeliki, Dionellis, Vasilis S, Asensio Aldave, Ainhoa, Yarahmadov, Tural, Rodriguez-Carballo, Eddie, Keogh, Adrian, Candinas, Daniel, Stroka, Deborah, Halazonetis, Thanos D   +10 more
openaire   +2 more sources