Results 211 to 220 of about 34,336 (231)
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Science, 2014
Multiple proteins modify and dismantle a key enzyme after DNA replication terminates [Also see Research Article by Maric et al. and Report by Priego Moreno et al.
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Multiple proteins modify and dismantle a key enzyme after DNA replication terminates [Also see Research Article by Maric et al. and Report by Priego Moreno et al.
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“Replisome”-controlled initiation of DNA replication
Journal of Theoretical Biology, 1971Abstract A model is presented for initiation of DNA replication according to which a membrane-bound structure, the “replisome”, is brought to maturity on a definite region of the bacterial chromosome. Maturation of replisomes is assumed to be a recurrent process the start and the end of which is marked by initiation of DNA replication.
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Motors, Switches, and Contacts in the Replisome
Annual Review of Biochemistry, 2009Replisomes are the protein assemblies that replicate DNA. They function as molecular motors to catalyze template-mediated polymerization of nucleotides, unwinding of DNA, the synthesis of RNA primers, and the assembly of proteins on DNA. The replisome of bacteriophage T7 contains a minimum of proteins, thus facilitating its study.
Samir M, Hamdan, Charles C, Richardson
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Understanding how the replisome works
Nature Structural & Molecular Biology, 2008Recent papers shed insight into the architecture and dynamics of the components of the bacterial replisome.
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Structures of the simplest replisome
Science, 2019Structural Biology The DNA replisome performs concerted parental-strand separation and DNA synthesis on both strands. Gao et al. report the cryo–electron microscopy structures of the minimum set of bacteriophage T7 proteins that can carry out leading- and lagging-strand synthesis at the replication fork (see the Perspective by Li and O'Donnell).
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Autism Research
AbstractAutism spectrum disorder (ASD) is a neurodevelopmental condition often associated with mitochondrial dysfunction, including increased mitochondrial DNA (mtDNA) copy number and impaired energy production. This study investigates the role of the mitochondrial replisome—specifically, the genes TFAM, TWNK, POLG, and TOP1MT—in mtDNA replication and ...
Valentina Rojas +8 more
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AbstractAutism spectrum disorder (ASD) is a neurodevelopmental condition often associated with mitochondrial dysfunction, including increased mitochondrial DNA (mtDNA) copy number and impaired energy production. This study investigates the role of the mitochondrial replisome—specifically, the genes TFAM, TWNK, POLG, and TOP1MT—in mtDNA replication and ...
Valentina Rojas +8 more
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The Fork Protection Complex: A Regulatory Hub at the Head of the Replisome.
Sub-cellular biochemistry, 2022D. B. Grabarczyk
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A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance
CellJuntao Yu +12 more
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Bacterial and Eukaryotic Replisome Machines.
JSM biochemistry and molecular biologyCellular genomic DNA is replicated by a multiprotein replisome machine. The replisome contains numerous essential factors that unwind, prime and synthesize each of the two strands of duplex DNA. The antiparallel structure of DNA, and unidirectional activity of DNA polymerases, requires the two strands of DNA to be extended in opposite directions, and ...
Nina, Yao, Mike, O'Donnell
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