Results 1 to 10 of about 19,982 (216)
Cohesin architecture and clustering in vivo [PDF]
eLife, 2021 Cohesin helps mediate sister chromatid cohesion, chromosome condensation, DNA repair, and transcription regulation. We exploited proximity-dependent labeling to define the in vivo interactions of cohesin domains with DNA or with other cohesin domains ...
Siheng Xiang, Douglas Koshland
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Diverse Roles of Cohesin in Chromosome Dynamics and Stem Cells [PDF]
BioTechThe cohesin complex is a highly conserved, ring-shaped protein assembly that plays fundamental roles in chromosome biology. Originally identified as the molecular glue that holds sister chromatids together from DNA replication until cell division ...
Eui-Hwan Choi
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Genome-wide control of RNA polymerase II activity by cohesin.
PLoS Genetics, 2013 Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest ...
Cheri A Schaaf +8 more
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Context-dependent regulation of IgH V(D)J recombination by cohesin-STAG1 and cohesin-STAG2 [PDF]
Nature CommunicationsCohesin-mediated loop extrusion is central to IgH V(D)J recombination in early developing B cells, driving D-to-JH rearrangements and VH-to-DJH rearrangements, with the latter step regulated by the cohesin release factor WAPL.
Fujung Chang +7 more
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Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes [PDF]
eLifeCohesin is a DNA tethering complex essential for chromosome structure and function. In fission yeast, defects in the cohesin loader Mis4 result in chromosome segregation defects and dysregulated expression of genes near chromosome ends.
Dorian Besson +10 more
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Cohesin acts as a transcriptional gatekeeper by restraining pause–release to promote processive elongation [PDF]
Nature CommunicationsCohesin organizes 3D chromatin architecture, including promoter–enhancer loops, yet its loss has surprisingly modest effects on steady-state gene expression.
Shoin Tei +7 more
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Chromosomal localization of cohesin is differentially regulated by WIZ, WAPL, and G9a
BMC Genomics, 2022 Background The cohesin complex is essential for proper chromosome structure and gene expression. Defects in cohesin subunits and regulators cause changes in cohesin complex dynamics and thereby alter three-dimensional genome organization.
Megan Justice +4 more
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Epigenetics & Chromatin, 2022 Background The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or STAG2 subunit, and two versions of
Ana Cuadrado +6 more
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eLife, 2020 Cohesin has essential roles in chromosome structure, segregation and repair. Cohesin binding to chromosomes is catalyzed by the cohesin loader, Mis4 in fission yeast. How cells fine tune cohesin deposition is largely unknown.
Adrien Birot +8 more
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Evidence for cohesin sliding along budding yeast chromosomes [PDF]
Open Biology, 2016 The ring-shaped cohesin complex is thought to topologically hold sister chromatids together from their synthesis in S phase until chromosome segregation in mitosis.
Maria Ocampo-Hafalla +3 more
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