Results 31 to 40 of about 26,113 (251)
Epigenetics & Chromatin, 2022 Background The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or STAG2 subunit, and two versions of
Ana Cuadrado +6 more
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Cohesin and CTCF control the dynamics of chromosome folding
Nature Genetics, 2022 Live-cell imaging shows that interactions within topologically associating domains are transient and frequent throughout the cell cycle. Convergent CTCF sites regulate the frequency and duration of interactions, which last a few minutes on average.
Pia Mach +15 more
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Cohesins and Cohesin-Regulators in Meiosis [PDF]
, 2012 Cells have rigorous mechanisms controlling sister chromatid cohesion during cell division to ensure proper distribution of genetic material to daughter cells. Errors in these mechanisms often lead to aneuploidy, frequently implicated in cell death, tumour development and infertility.
Adela Calvente, Jos L.
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Nature Structural & Molecular Biology, 2022 Developmental gene expression is often controlled by distal regulatory DNA elements called enhancers. Distant enhancer action is restricted to structural chromosomal domains that are flanked by CTCF-associated boundaries and formed through cohesin ...
Niels J. Rinzema +12 more
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NIPBL and cohesin: new take on a classic tale.
Trends in Cell Biology, 2023 Cohesin folds the genome in dynamic chromatin loops and holds the sister chromatids together. NIPBLScc2 is currently considered the cohesin loader, a role that may need reevaluation.
Dácil Alonso-Gil, A. Losada
semanticscholar +1 more source
Cohesin is required for long-range enhancer action at the Shh locus
Nature Structural & Molecular Biology, 2022 The regulatory landscapes of developmental genes in mammals can be complex, with enhancers spread over many hundreds of kilobases. It has been suggested that three-dimensional genome organization, particularly topologically associating domains formed by ...
Lauren Kane +6 more
semanticscholar +1 more source
Cohesin and Human Disease [PDF]
Annual Review of Genomics and Human Genetics, 2008 Cornelia de Lange syndrome (CdLS) is a dominant multisystem disorder caused by a disruption of cohesin function. The cohesin ring complex is composed of four protein subunits and more than 25 additional proteins involved in its regulation. The discovery that this complex also has a fundamental role in long-range regulation of transcription in ...
Jinglan, Liu, Ian D, Krantz
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Evidence for cohesin sliding along budding yeast chromosomes [PDF]
Open Biology, 2016 The ring-shaped cohesin complex is thought to topologically hold sister chromatids together from their synthesis in S phase until chromosome segregation in mitosis.
Maria Ocampo-Hafalla +3 more
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It’s all in the numbers: Cohesin stoichiometry
Frontiers in Molecular Biosciences, 2022 Cohesin, a structural maintenance of chromosome (SMC) complex, organizes chromatin into three-dimensional structures by threading chromatin into loops and stabilizing long-range chromatin interactions. Four subunits in a 1:1:1:1 ratio compose the cohesin
Avi Matityahu, Itay Onn
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The cohesin ring concatenates sister DNA molecules [PDF]
, 2008 Sister chromatid cohesion, which is essential for mitosis, is mediated by a multi-subunit protein complex called cohesin whose Scc1, Smc1, and Smc3 subunits form a tripartite ring structure.
Nasmyth, Kim +4 more
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