Results 31 to 40 of about 14,462 (190)
Single-Molecule Imaging Reveals a Collapsed Conformational State for DNA-Bound Cohesin
Cell Reports, 2016 Cohesin is essential for the hierarchical organization of the eukaryotic genome and plays key roles in many aspects of chromosome biology. The conformation of cohesin bound to DNA remains poorly defined, leaving crucial gaps in our understanding of how ...
Johannes Stigler +3 more
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Epigenetics & Chromatin, 2021 Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-range DNA–DNA interactions through the process
Arkadiy K. Golov +3 more
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Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance
Frontiers in Oncology, 2021 The occurrence of gene mutation is a major contributor to the initiation and propagation of acute myeloid leukemia (AML). Accumulating evidence suggests that genes encoding cohesin subunits have a high prevalence of mutations in AML, especially in the t ...
Caixia Han +6 more
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Cohesin loading and sliding [PDF]
Journal of Cell Science, 2011 Cohesin is best known as a crucial component of chromosomal stability. Composed of several essential subunits in budding yeast, cohesin forms a ring-like complex that is thought to embrace sister chromatids, thereby physically linking them until their timely segregation during cell division.
Maria T, Ocampo-Hafalla, Frank, Uhlmann
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Chromatin insulators and cohesins [PDF]
EMBO reports, 2008 Chromatin insulators have evolved to regulate transcription by using regulatory elements that are often distant from each other on the linear genome. This feature is position‐dependent—that is, a functional insulator must be positioned between the enhancer and its target promoter (Wallace & Felsenfeld, 2007).
Anita, Göndör, Rolf, Ohlsson
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Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A.
PLoS Genetics, 2013 Chromosome duplication and transmission into daughter cells requires the precisely orchestrated binding and release of cohesin. We found that the Drosophila histone chaperone NAP1 is required for cohesin release and sister chromatid resolution during ...
Yuri M Moshkin +9 more
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A folded conformation of MukBEF and Cohesin [PDF]
Nature Structural & Molecular Biology, 2018 Abstract Structural maintenance of chromosomes (SMC)-kleisin complexes organize chromosomal DNAs in all domains of life, where they have key roles in chromosome segregation, DNA repair and regulation of gene expression. They function through topological entrapment and active translocation of DNA, but the underlying conformational ...
Frank Bürmann +9 more
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PLoS ONE, 2014 The immunoglobulin heavy chain locus (Igh) features higher-order chromosomal interactions to facilitate stage-specific assembly of the Ig molecule.
Gamze Günal-Sadık +5 more
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Cohesin-Mediated Chromatin Interactions and Autoimmunity
Frontiers in Immunology, 2022 Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-
Venkataragavan Chandrasekaran +12 more
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Genome-wide mapping of the cohesin complex in the yeast Saccharomyces cerevisiae.
PLoS Biology, 2004 In eukaryotic cells, cohesin holds sister chromatids together until they separate into daughter cells during mitosis. We have used chromatin immunoprecipitation coupled with microarray analysis (ChIP chip) to produce a genome-wide description of cohesin ...
Earl F Glynn +7 more
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