Results 21 to 30 of about 19,982 (216)

Cohesins and Cohesin-Regulators in Meiosis [PDF]

, 2012
Cells have rigorous mechanisms controlling sister chromatid cohesion during cell division to ensure proper distribution of genetic material to daughter cells. Errors in these mechanisms often lead to aneuploidy, frequently implicated in cell death, tumour development and infertility.
Adela Calvente, Jos L.
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The cohesin ring concatenates sister DNA molecules [PDF]

, 2008
Sister chromatid cohesion, which is essential for mitosis, is mediated by a multi-subunit protein complex called cohesin whose Scc1, Smc1, and Smc3 subunits form a tripartite ring structure.
Arumugam, P, Nasmyth, Kim, Haering, Christian H., Haering, CH, Metson, Jean, Metson, J, Arumugam, Prakash, Nasmyth, K, Farcas, Ana-Maria, Farcas, AM   +9 more
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Cohesin and Human Disease [PDF]

Annual Review of Genomics and Human Genetics, 2008
Cornelia de Lange syndrome (CdLS) is a dominant multisystem disorder caused by a disruption of cohesin function. The cohesin ring complex is composed of four protein subunits and more than 25 additional proteins involved in its regulation. The discovery that this complex also has a fundamental role in long-range regulation of transcription in ...
Jinglan, Liu, Ian D, Krantz
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The loopy world of cohesin

eLife, 2021
DNA loops can be formed by a mechanism in which the cohesin complex pulls DNA strands through its ring structure using biased Brownian motion.
Kazuhiro Maeshima, Shiori Iida
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Regulation of cohesin cleavage during meiosis in Saccharomyces cerevisiae [PDF]

, 2017
Meiosis is a specialized form of cell division where homologous chromosomes are segregated in meiosis I before sister chromatids are segregated in meiosis II.
Galander, Stefan
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Cohesin Mutations in Cancer [PDF]

Cold Spring Harbor Perspectives in Medicine, 2016
Cohesin is a large ring-shaped protein complex, conserved from yeast to human, which participates in most DNA transactions that take place in the nucleus. It mediates sister chromatid cohesion, which is essential for chromosome segregation and homologous recombination (HR)-mediated DNA repair.
Magali, De Koninck, Ana, Losada
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It’s all in the numbers: Cohesin stoichiometry

Frontiers in Molecular Biosciences, 2022
Cohesin, a structural maintenance of chromosome (SMC) complex, organizes chromatin into three-dimensional structures by threading chromatin into loops and stabilizing long-range chromatin interactions. Four subunits in a 1:1:1:1 ratio compose the cohesin
Avi Matityahu, Itay Onn
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Topological in vitro loading of the budding yeast cohesin ring onto DNA

Life Science Alliance, 2018
The biochemical reconstitution of topological DNA binding by budding yeast cohesin yields surprises and opens opportunities to exploit experimental approaches developed in this model organism.
Masashi Minamino, Torahiko L Higashi, Céline Bouchoux, Frank Uhlmann   +3 more
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Comprehensive multiomics analyses reveal pervasive involvement of aberrant cohesin binding in transcriptional and chromosomal disorder of cancer cells

iScience, 2023
Summary: Chromatin organization, whose malfunction causes various diseases including cancer, is fundamentally controlled by cohesin. While cancer cells have been found with mutated or misexpressed cohesin genes, there is no comprehensive survey about the
Jiankang Wang, Ryuichiro Nakato
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Genetic heterogeneity in Cornelia de Lange syndrome (CdLS) and CdLS-like phenotypes with observed and predicted levels of mosaicism [PDF]

, 2014
Cornelia de Lange syndrome (CdLS) is a multisystem disorder with distinctive facial appearance, intellectual disability and growth failure as prominent features.
Aldridge, Roland, Green, Andrew J, Lampe, A., McKee, Shane A., Kingston, Helen, Kayserili, H., Bitner-Glindzicz, M, Chan, Cheng Yee, Kayserili, Hülya, Cooper, Nicola S, Mansour, S, Chandler, K, Ross, Alison, Bitner-Glindzicz, Maria, Ansari, M., Aldridge, R., Bennett, CP, Donnelly, D. E., Davidson, R, Chan, C. Y., Girisha, KM, Poke, G., Cook, J., Lampe, Anne K., Pilz, Daniela T, Chan, C., Poke, Gemma, Park, Soo-Mi, Ferry, Q., Lam, Wayne K, Cook, JA, Splitt, M., Johnson, Diana S., Wee, Jamie S., Deshpande, C, Falkenberg Smeland, Marie, Chan, CY, Avci, Şahin, Hurst, Jane A, Lam, W. K., Deshpande, C., Meynert, A., Bennett, C. P., Green, A. J., Donnai, D., Bengani, Hemant, Pilz, D. T., McEntagart, M, Thompson, Elizabeth M., Mansour, Sahar, Deshpande, Charu, McConnell, Vivienne, Davidson, Rosemarie, FitzPatrick, D. R., McEntagart, Meriel, Cooper, Nicola S., Thompson, E. M., Josifova, D., Holder, S. E., Green, Andrew J., Taylor, M. S., Homfray, Tessa, Kingston, H, FitzPatrick, DR, Tatton-Brown, Katrina, Hurst, J. A., Taylor, MS, Barnicoat, Angela, Magee, A. C., Parker, M. J., Wilson, L, Clayton-Smith, Jill, Flinter, F., Tolmie, J., Wee, J. S., Donnelly, Deirdre E., Lampe, Anne K, Fisher, Richard B, Green, AJ, Redeker, Egbert, Mehta, Sarju G, Hennekam, R. C. M., Prescott, K., Sisodiya, S., Mohammed, S., Wilson, Louise, Cox, H., Johnson, D. S., Mercer, C, Mohammed, S, Hennekam, RCM, Tatton-Brown, K, Redeker, E, Tolmie, John, Parker, Michael J., Meynert, Alison M, McEntagart, M., Vogt, Julie, Vogt, J, Chandler, K., Williamson, K., Fisher, R. B., Parker, M., et al., Magee, Alex C., Cox, H, Taylor, Martin S., Fryer, A, McKee, S. A., Ansari, M, Fryer, Alan, Firth, Helen V, Donnai, Dian, Firth, H. V., Hurst, JA, Lynch, Sally-Ann, Park, S-M, Brady, A. F., Behnam, Mahdiyeh, Cooper, N. S., Parker, MJ, Pilz, Daniela T., Harrison, V, Parker, Michael J, Wakeling, Emma, Behnam, M, Cooper, NS, Lampe, AK, Johnson, Diana S, Clayton-Smith, J., McKee, SA, McConnell, V, Homfray, T, Tolmie, J, McConnell, V., Lam, Wayne K., Barnicoat, A., Davidson, R., Firth, HV, Bennett, Christopher P, Ross, A, Donnelly, Deirdre E, Pilz, DT, Cilliers, D., Hennekam, Raoul C M, Taylor, Martin S; id_orcid, Falkenberg Smeland, M, Harrison, V., Holder, Susan E., Mercer, C., Brady, Angela F., Thompson, EM, Josifova, D, Stewart, Fiona, Harrison, Victoria, Lynch, SA, Smeland, Marie Falkenberg, Mehta, Sarju G., Wilkie, A, Wakeling, E., Firth, Helen V., Cilliers, Deirdre, Flinter, F, Girisha, Katta M., Splitt, Miranda, Meynert, A. M., Mehta, SG, Lam, WK, Homfray, T., Kayserili, H, Wee, Jamie S, Mohammed, Shehla, Cox, Helen, Bengani, H, Brady, Angela F, Donnelly, DE, Hennekam, RC, Barnicoat, A, Sisodiya, Sanjay, Ferry, Q, Kinning, Esther, Kinning, E., Fisher, Richard B., Wee, JS, Smeland, MF, Meynert, Alison M., Magee, Alex C, Brady, AF, Nellaker, C., Bitner-Glindzicz, M., Mansour, S., Holder, SE, Prescott, Katrina, Lynch, S-A, Cook, Jacqueline A, Williamson, Kathleen, Ruddy, D, Avci, S, Johnson, DS, Falkenberg Smeland, M., Stewart, F, Clayton-Smith, J, Lampe, A. K., Nellåker, C, Fryer, A., Smeland, M., Redeker, E., Girisha, K. M., Hurst, Jane A., Chandler, Kate, Avci, ahin, Nellåker, Christoffer, Lynch, S.-A., Ansari, Morad, FitzPatrick, David R, Wilson, L., Hennekam, Raoul C. M., Fitzpatrick, David R., Poke, G, Cilliers, D, Rosser, E., Ruddy, Deborah, Park, S.-M., Donnai, D, Wilkie, Andrew, Holden, Simon, Meynert, AM, Tatton-Brown, K., McKee, Shane A, Hennekam, R., Vogt, J., Magee, AC, Holder, Susan E, Ruddy, D., Aldridge, R, Williamson, K, Flinter, Frances, Mehta, S. G., Fisher, RB, Kinning, E, Park, SM, Prescott, K, Splitt, M, Josifova, Dragana, Girisha, Katta M, Holden, S., Rosser, E, Wakeling, E, Wilkie, A., Mercer, Catherine, Bengani, H., Ross, A., Kingston, H., Avci, Ş., Thompson, Elizabeth M, Rosser, Elisabeth, Cook, Jacqueline A., Ferry, Quentin, Sisodiya, S, Stewart, F., Behnam, M., Holden, S, Cook, J. A., Bennett, Christopher P.   +263 more
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