Results 21 to 30 of about 26,113 (251)

Cohesin residency determines chromatin loop patterns [PDF]

eLife, 2020
The organization of chromatin into higher order structures is essential for chromosome segregation, the repair of DNA-damage, and the regulation of gene expression.
Lorenzo Costantino, Tsung-Han S Hsieh, Rebecca Lamothe, Xavier Darzacq, Douglas Koshland   +4 more
doaj   +2 more sources

Intermediate step of cohesin’s ATPase cycle allows cohesin to entrap DNA [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Cohesin is an ATPase that organizes chromosome structure for chromosome segregation, gene expression, and DNA repair. Its function has been implicated in the prevention of cancer, birth defects, and several human disorders.
Çamdere, Gamze Ö, Carlborg, Kristian K, Koshland, Douglas   +2 more
openaire   +6 more sources

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization [PDF]

Nature Structural & Molecular Biology, 2018
Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also known as STAG1) or SA2 (also known as STAG2) are present in all cell types. We report here their genomic distribution and specific contributions to genome organization in human cells.
Kojic, Aleksandar, Cuadrado, Ana, De Koninck, Magali, Giménez-Llorente, Daniel, Rodríguez-Corsino, Miriam, Gómez-López, Gonzalo, Le Dily, François, Marti-Renom, Marc A, Losada, Ana, Losada, Ana   +9 more
openaire   +4 more sources

A cohesin–RAD21 interactome

Biochemical Journal, 2012
The cohesin complex holds the sister chromatids together from S-phase until the metaphase-to-anaphase transition, and ensures both their proper cohesion and timely separation. In addition to its canonical function in chromosomal segregation, cohesin has been suggested by several lines of investigation in recent years to play additional roles in ...
Anil K, Panigrahi, Nenggang, Zhang, Subhendu K, Otta, Debananda, Pati   +3 more
openaire   +3 more sources

Mediator and Cohesin Connect Gene Expression and Chromatin Architecture [PDF]

Nature, 2010
Transcription factors control cell-specific gene expression programs through interactions with diverse coactivators and the transcription apparatus.
M. Kagey, J. Newman, S. Bilodeau, Ye Zhan, D. Orlando, Nynke L. van Berkum, C. Ebmeier, Jesse Goossens, P. Rahl, S. Levine, D. Taatjes, J. Dekker, R. Young   +12 more
semanticscholar   +3 more sources

A minimal cellulosome-like system in Cellulosilyticum lentocellum. [PDF]

FEBS Open Bio
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
Allan J, Alstrom-Moore A, Black GW.
europepmc   +2 more sources

Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1

Nature Genetics, 2022
Micro-C and nascent transcript profiling in mouse embryonic stem cells shows that enhancer–promoter interactions are robust to acute depletion of CTCF, cohesin, WAPL or YY1.
Tsung-Han S. Hsieh, Claudia Cattoglio, E. Slobodyanyuk, A. Hansen, X. Darzacq, R. Tjian   +5 more
semanticscholar   +1 more source

Dynamics of CTCF and cohesin mediated chromatin looping revealed by live-cell imaging

bioRxiv, 2021
Animal genomes are folded into loops and topologically associating domains (TADs) by CTCF and cohesin, but whether these loops are stable or dynamic is unknown.
Michele Gabriele, Hugo B. Brandão, Simon Grosse-Holz, Asmita Jha, G. Dailey, Claudia Cattoglio, Tsung-Han S. Hsieh, L. Mirny, C. Zechner, A. Hansen   +9 more
semanticscholar   +1 more source

CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion

Nature, 2023
In eukaryotes, genomic DNA is extruded into loops by cohesin^ 1 . By restraining this process, the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating domains (TADs)^ 2 , 3 that have important roles in gene regulation and ...
I. Davidson, R. Barth, M. Zaczek, J. van der Torre, Wen Tang, Kota Nagasaka, R. Janissen, J. Kerssemakers, G. Wutz, C. Dekker, J. Peters   +10 more
semanticscholar   +1 more source

Chromosomal localization of cohesin is differentially regulated by WIZ, WAPL, and G9a

BMC Genomics, 2022
Background The cohesin complex is essential for proper chromosome structure and gene expression. Defects in cohesin subunits and regulators cause changes in cohesin complex dynamics and thereby alter three-dimensional genome organization.
Megan Justice, Audra F. Bryan, Juanita C. Limas, Jeanette Gowen Cook, Jill M. Dowen   +4 more
doaj   +1 more source