Results 21 to 30 of about 18,597 (218)
Cohesin residency determines chromatin loop patterns [PDF]
eLife, 2020 The organization of chromatin into higher order structures is essential for chromosome segregation, the repair of DNA-damage, and the regulation of gene expression.
Lorenzo Costantino +4 more
doaj +3 more sources
Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization [PDF]
Nature Structural & Molecular Biology, 2018 Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also known as STAG1) or SA2 (also known as STAG2) are present in all cell types. We report here their genomic distribution and specific contributions to genome organization in human cells.
Kojic, Aleksandar +9 more
openaire +5 more sources
Interaction Between Rec8 and Mis4 Is Required for Axis-Loop Chromatin Formation and Homologous Chromosome Recombination During Meiosis. [PDF]
Genes CellsWe identified a Mis4 cohesin loader mutant that is specifically defective in chromatin axis formation and homologous recombination while retaining normal sister chromatid cohesion. The mis4‐LR mutant, carrying the L1150S and R1159G amino acid substitutions, exhibited reduced interaction between Mis4 and Rec8, suggesting a meiosis‐specific role for the ...
Sakuno T +3 more
europepmc +2 more sources
Cohesins and Cohesin-Regulators in Meiosis [PDF]
, 2012 Cells have rigorous mechanisms controlling sister chromatid cohesion during cell division to ensure proper distribution of genetic material to daughter cells. Errors in these mechanisms often lead to aneuploidy, frequently implicated in cell death, tumour development and infertility.
Adela Calvente, Jos L.
openaire +1 more source
The torments of the cohesin ring [PDF]
Nucleus, 2017 Cohesin is a ring-shaped protein complex which comprises the Smc1, Smc3 and Scc1 subunits. It topologically embraces chromosomal DNA to connect sister chromatids and stabilize chromatin loops. It is required for proper chromosomal segregation, DNA repair and transcriptional regulation. We have recently reported that cohesin rings can adopt a "collapsed"
Chavda, A., Ang, K., Ivanov, D.
openaire +3 more sources
The cohesin ring concatenates sister DNA molecules [PDF]
, 2008 Sister chromatid cohesion, which is essential for mitosis, is mediated by a multi-subunit protein complex called cohesin whose Scc1, Smc1, and Smc3 subunits form a tripartite ring structure.
Arumugam, P +9 more
core +1 more source
Cohesin and Human Disease [PDF]
Annual Review of Genomics and Human Genetics, 2008 Cornelia de Lange syndrome (CdLS) is a dominant multisystem disorder caused by a disruption of cohesin function. The cohesin ring complex is composed of four protein subunits and more than 25 additional proteins involved in its regulation. The discovery that this complex also has a fundamental role in long-range regulation of transcription in ...
Jinglan, Liu, Ian D, Krantz
openaire +2 more sources
Cohesin Mutations in Cancer [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 Cohesin is a large ring-shaped protein complex, conserved from yeast to human, which participates in most DNA transactions that take place in the nucleus. It mediates sister chromatid cohesion, which is essential for chromosome segregation and homologous recombination (HR)-mediated DNA repair.
Magali, De Koninck, Ana, Losada
openaire +2 more sources
Cohesin Mutations in Cancer: Emerging Therapeutic Targets [PDF]
, 2021 The cohesin complex is crucial for mediating sister chromatid cohesion and for hierarchal three-dimensional organization of the genome. Mutations in cohesin genes are present in a range of cancers.
Julia A. Horsfield +2 more
core +1 more source
eLife, 2021 DNA loops can be formed by a mechanism in which the cohesin complex pulls DNA strands through its ring structure using biased Brownian motion.
Kazuhiro Maeshima, Shiori Iida
openaire +3 more sources