Results 21 to 30 of about 14,462 (190)
Evidence for cohesin sliding along budding yeast chromosomes [PDF]
Open Biology, 2016 The ring-shaped cohesin complex is thought to topologically hold sister chromatids together from their synthesis in S phase until chromosome segregation in mitosis.
Maria Ocampo-Hafalla +3 more
doaj +1 more source
Cohesin and chromosome segregation [PDF]
Current Biology, 2018 Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. Cohesin is best known for its role in chromosome segregation, where it provides the cohesion that is established between the two newly duplicated sister chromatids during S phase.
Makrantoni, Vasso, Marston, Adele L
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Cohesins and Cohesin-Regulators in Meiosis [PDF]
, 2012 Cells have rigorous mechanisms controlling sister chromatid cohesion during cell division to ensure proper distribution of genetic material to daughter cells. Errors in these mechanisms often lead to aneuploidy, frequently implicated in cell death, tumour development and infertility.
Adela Calvente, Jos L.
openaire +1 more source
Cohesin and Human Disease [PDF]
Annual Review of Genomics and Human Genetics, 2008 Cornelia de Lange syndrome (CdLS) is a dominant multisystem disorder caused by a disruption of cohesin function. The cohesin ring complex is composed of four protein subunits and more than 25 additional proteins involved in its regulation. The discovery that this complex also has a fundamental role in long-range regulation of transcription in ...
Jinglan, Liu, Ian D, Krantz
openaire +2 more sources
iScience, 2023 Summary: Chromatin organization, whose malfunction causes various diseases including cancer, is fundamentally controlled by cohesin. While cancer cells have been found with mutated or misexpressed cohesin genes, there is no comprehensive survey about the
Jiankang Wang, Ryuichiro Nakato
doaj +1 more source
Cohesin Mutations in Cancer [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 Cohesin is a large ring-shaped protein complex, conserved from yeast to human, which participates in most DNA transactions that take place in the nucleus. It mediates sister chromatid cohesion, which is essential for chromosome segregation and homologous recombination (HR)-mediated DNA repair.
Magali, De Koninck, Ana, Losada
openaire +2 more sources
Topological in vitro loading of the budding yeast cohesin ring onto DNA
Life Science Alliance, 2018 The biochemical reconstitution of topological DNA binding by budding yeast cohesin yields surprises and opens opportunities to exploit experimental approaches developed in this model organism.
Masashi Minamino +3 more
doaj +1 more source
eLife, 2021 DNA loops can be formed by a mechanism in which the cohesin complex pulls DNA strands through its ring structure using biased Brownian motion.
Kazuhiro Maeshima, Shiori Iida
openaire +3 more sources
PLoS Genetics, 2015 The Structural Maintenance of Chromosome (SMC) complex, termed cohesin, is essential for sister chromatid cohesion. Cohesin is also important for chromosome condensation, DNA repair, and gene expression. Cohesin is comprised of Scc3, Mcd1, Smc1, and Smc3.
Ola Orgil +5 more
doaj +1 more source
Pds5 promotes cohesin acetylation and stable cohesin–chromosome interaction [PDF]
EMBO reports, 2012 Pds5 and Wpl1 act as anti‐establishment factors preventing sister‐chromatid cohesion until counteracted in S‐phase by the cohesin acetyl‐transferase Eso1. However, Pds5 is also required to maintain sister‐chromatid cohesion in G2. Here, we show that Pds5 is essential for cohesin acetylation by Eso1 and ensures the maintenance of cohesion by promoting a
Vaur, Sabine +4 more
openaire +4 more sources