Results 41 to 50 of about 19,982 (216)
PLoS ONE, 2014 The immunoglobulin heavy chain locus (Igh) features higher-order chromosomal interactions to facilitate stage-specific assembly of the Ig molecule.
Gamze Günal-Sadık +5 more
doaj +1 more source
Genome-wide mapping of the cohesin complex in the yeast Saccharomyces cerevisiae.
PLoS Biology, 2004 In eukaryotic cells, cohesin holds sister chromatids together until they separate into daughter cells during mitosis. We have used chromatin immunoprecipitation coupled with microarray analysis (ChIP chip) to produce a genome-wide description of cohesin ...
Earl F Glynn +7 more
doaj +1 more source
eLife, 2019 Cohesin mediates higher order chromosome structure. Its biological activities require topological entrapment of DNA within a lumen(s) formed by cohesin subunits.
Vincent Guacci +3 more
doaj +1 more source
Cohesin-Mediated Chromatin Interactions and Autoimmunity
Frontiers in Immunology, 2022 Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-
Venkataragavan Chandrasekaran +12 more
doaj +1 more source
Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
Cell Reports, 2020 Summary: How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression. Here,
James D.P. Rhodes +15 more
doaj +1 more source
Linking Cohesin to Gene Regulation [PDF]
, 2008 During cell division the cohesin complex mediates the pairing of sister chromatids. Emerging evidence shows that cohesin also has roles in interphase cells.
van Steensel, Bas, Peric-Hupkes, Daniel
core +1 more source
Cohesin-dependence of neuronal gene expression relates to chromatin loop length
eLife, 2022 Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is still emerging. Here, we show a prominent role for cohesin in the expression of genes that facilitate neuronal maturation and homeostasis.
Lesly Calderon +15 more
doaj +1 more source
Cohesin dynamics during meiotic prophase [PDF]
, 2014 For faithful segregation during meiosis, chromosomes must be physically linked by both sister chromatid cohesion (SCC), provided by cohesin, and at least one crossover (CO).
Testori, Sarah
core +1 more source
Intermediate step of cohesin’s ATPase cycle allows cohesin to entrap DNA [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Cohesin is an ATPase that organizes chromosome structure for chromosome segregation, gene expression, and DNA repair. Its function has been implicated in the prevention of cancer, birth defects, and several human disorders.
Çamdere, Gamze Ö +2 more
openaire +4 more sources
Designing a new cross-linkable cohesin complex for studying cohesin`s interaction with DNA [PDF]
, 2012 Sister chromatid cohesion is essential for accurate chromosome segregation. Cohesion is generated by cohesin, a conserved multi-subunit protein complex composed of four core subunits: Smc1, Smc3, Scc1, and Scc3.
Nasmyth, Kim, Uluocak, Pelin
core +2 more sources