Results 41 to 50 of about 14,462 (190)
Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
Cell Reports, 2020 Summary: How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression. Here,
James D.P. Rhodes +15 more
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eLife, 2019 Cohesin mediates higher order chromosome structure. Its biological activities require topological entrapment of DNA within a lumen(s) formed by cohesin subunits.
Vincent Guacci +3 more
doaj +1 more source
Cohesin-dependence of neuronal gene expression relates to chromatin loop length
eLife, 2022 Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is still emerging. Here, we show a prominent role for cohesin in the expression of genes that facilitate neuronal maturation and homeostasis.
Lesly Calderon +15 more
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Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements. [PDF]
PLoS Genetics, 2016 The cohesin protein complex mediates sister chromatid cohesion and participates in transcriptional control of genes that regulate growth and development.
Amanda Swain +7 more
doaj +1 more source
Developing a peptide to disrupt cohesin head domain interactions
iScience, 2023 Summary: Cohesin mediates the 3-D structure of chromatin and is involved in maintaining genome stability and function. The cohesin core comprises Smc1 and Smc3, elongated-shaped proteins that dimerize through globular domains at their edges, called head ...
Maria Elias +9 more
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Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization [PDF]
Nature Structural & Molecular Biology, 2018 Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also known as STAG1) or SA2 (also known as STAG2) are present in all cell types. We report here their genomic distribution and specific contributions to genome organization in human cells.
Kojic, Aleksandar +9 more
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STAG2 promotes the myelination transcriptional program in oligodendrocytes
eLife, 2022 Cohesin folds chromosomes via DNA loop extrusion. Cohesin-mediated chromosome loops regulate transcription by shaping long-range enhancer–promoter interactions, among other mechanisms.
Ningyan Cheng +5 more
doaj +1 more source
Mechanical disengagement of the cohesin ring
Nature Structural & Molecular Biology, 2023 AbstractCohesin forms a proteinaceous ring that is thought to link sister chromatids by entrapping DNA and counteracting the forces generated by the mitotic spindle. Whether individual cohesins encircle both sister DNAs and how cohesin opposes spindle-generated forces remains unknown.
Martina Richeldi +5 more
openaire +3 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Epigenetics & ChromatinBackground The evolutionarily conserved cohesin complex is a pleiotropic regulator of chromosome structure and function, participating in sister chromatid cohesion, transcriptional regulation of genes, DNA replication, and DNA repair.
Natalie L. Rittenhouse +3 more
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