Results 41 to 50 of about 18,597 (218)
PLoS ONE, 2014 The immunoglobulin heavy chain locus (Igh) features higher-order chromosomal interactions to facilitate stage-specific assembly of the Ig molecule.
Gamze Günal-Sadık +5 more
doaj +1 more source
Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A.
PLoS Genetics, 2013 Chromosome duplication and transmission into daughter cells requires the precisely orchestrated binding and release of cohesin. We found that the Drosophila histone chaperone NAP1 is required for cohesin release and sister chromatid resolution during ...
Yuri M Moshkin +9 more
doaj +1 more source
A folded conformation of MukBEF and Cohesin [PDF]
Nature Structural & Molecular Biology, 2018 Abstract Structural maintenance of chromosomes (SMC)-kleisin complexes organize chromosomal DNAs in all domains of life, where they have key roles in chromosome segregation, DNA repair and regulation of gene expression. They function through topological entrapment and active translocation of DNA, but the underlying conformational ...
Frank Bürmann +9 more
openaire +4 more sources
Genome-wide mapping of the cohesin complex in the yeast Saccharomyces cerevisiae.
PLoS Biology, 2004 In eukaryotic cells, cohesin holds sister chromatids together until they separate into daughter cells during mitosis. We have used chromatin immunoprecipitation coupled with microarray analysis (ChIP chip) to produce a genome-wide description of cohesin ...
Earl F Glynn +7 more
doaj +1 more source
Cohesin dynamics during meiotic prophase [PDF]
, 2014 For faithful segregation during meiosis, chromosomes must be physically linked by both sister chromatid cohesion (SCC), provided by cohesin, and at least one crossover (CO).
Testori, Sarah
core +1 more source
Linking Cohesin to Gene Regulation [PDF]
, 2008 During cell division the cohesin complex mediates the pairing of sister chromatids. Emerging evidence shows that cohesin also has roles in interphase cells.
van Steensel, Bas, Peric-Hupkes, Daniel
core +1 more source
eLife, 2019 Cohesin mediates higher order chromosome structure. Its biological activities require topological entrapment of DNA within a lumen(s) formed by cohesin subunits.
Vincent Guacci +3 more
doaj +1 more source
Designing a new cross-linkable cohesin complex for studying cohesin`s interaction with DNA [PDF]
, 2012 Sister chromatid cohesion is essential for accurate chromosome segregation. Cohesion is generated by cohesin, a conserved multi-subunit protein complex composed of four core subunits: Smc1, Smc3, Scc1, and Scc3.
Nasmyth, Kim, Uluocak, Pelin
core +4 more sources
Cohesin-dependence of neuronal gene expression relates to chromatin loop length
eLife, 2022 Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is still emerging. Here, we show a prominent role for cohesin in the expression of genes that facilitate neuronal maturation and homeostasis.
Lesly Calderon +15 more
doaj +1 more source
Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
Cell Reports, 2020 Summary: How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression. Here,
James D.P. Rhodes +15 more
doaj +1 more source