Results 61 to 70 of about 26,113 (251)

Mechanical disengagement of the cohesin ring

Nature Structural & Molecular Biology, 2023
Cohesin forms a proteinaceous ring that is thought to link sister chromatids by entrapping DNA and counteracting the forces generated by the mitotic spindle.
Martina Richeldi, Georgii Pobegalov, T. Higashi, Karolina Gmurczyk, F. Uhlmann, M. Molodtsov   +5 more
semanticscholar   +1 more source

The torments of the cohesin ring [PDF]

Nucleus, 2017
Cohesin is a ring-shaped protein complex which comprises the Smc1, Smc3 and Scc1 subunits. It topologically embraces chromosomal DNA to connect sister chromatids and stabilize chromatin loops. It is required for proper chromosomal segregation, DNA repair and transcriptional regulation. We have recently reported that cohesin rings can adopt a "collapsed"
Chavda, A., Ang, K., Ivanov, D.
openaire   +3 more sources

Distinct Functions of Human Cohesin-SA1 and Cohesin-SA2 in Double-Strand Break Repair [PDF]

, 2014
Cohesin is an essential multiprotein complex that mediates sister chromatid cohesion critical for proper segregation of chromosomes during cell division. Cohesin is also involved in DNA double-strand break (DSB) repair.
Pham, Hoang Xuan, Chen, Hsiao-Yuan, Schmiesing, John A, Zeng, Weihua, Berns, Michael, Kim, Jong-Soo, Kong, Xiangduo, Ball, Alexander R, Yokomori, Kyoko   +8 more
core   +1 more source

Cohesin-mediated loop anchors confine the locations of human replication origins

Nature, 2022
DNA replication occurs through an intricately regulated series of molecular events and is fundamental for genome stability1,2. At present, it is unknown how the locations of replication origins are determined in the human genome. Here we dissect the role
Daniel J. Emerson, Pei-Yao A. Zhao, Ashley L. Cook, R. J. Barnett, Kyle N. Klein, D. Saulebekova, Chunmin Ge, Linda Zhou, Zoltan Simandi, Miriam K. Minsk, Katelyn R. Titus, Weitao Wang, Wanfeng Gong, Di Zhang, Li-Yan Yang, Sergey V. Venev, J. Gibcus, Hong-Bo Yang, Takayo Sasaki, Masato T. Kanemaki, Feng Yue, J. Dekker, Chun-Long Chen, David M. Gilbert, Jennifer E. Phillips-Cremins   +24 more
semanticscholar   +1 more source

A folded conformation of MukBEF and Cohesin [PDF]

Nature Structural & Molecular Biology, 2018
Abstract Structural maintenance of chromosomes (SMC)-kleisin complexes organize chromosomal DNAs in all domains of life, where they have key roles in chromosome segregation, DNA repair and regulation of gene expression. They function through topological entrapment and active translocation of DNA, but the underlying conformational ...
Frank Bürmann, Byung-Gil Lee, Thane Than, Ludwig Sinn, Francis J O’Reilly, Stanislau Yatskevich, Juri Rappsilber, Bin Hu, Kim Nasmyth, Jan Löwe   +9 more
openaire   +4 more sources

Chromatin jets define the properties of cohesin-driven in vivo loop extrusion.

Molecules and Cells, 2022
Complex genomes show intricate organization in three-dimensional (3D) nuclear space. Current models posit that cohesin extrudes loops to form self-interacting domains delimited by the DNA binding protein CTCF.
Ya Guo, Ediem Al-Jibury, Rosalba Garcia-Millan, Konstantinos Ntagiantas, James W D King, Alexander J. Nash, N. Galjart, B. Lenhard, D. Rueckert, A. Fisher, G. Pruessner, M. Merkenschlager   +11 more
semanticscholar   +1 more source

Genome-wide mapping of the cohesin complex in the yeast Saccharomyces cerevisiae.

PLoS Biology, 2004
In eukaryotic cells, cohesin holds sister chromatids together until they separate into daughter cells during mitosis. We have used chromatin immunoprecipitation coupled with microarray analysis (ChIP chip) to produce a genome-wide description of cohesin ...
Earl F Glynn, Paul C Megee, Hong-Guo Yu, Cathy Mistrot, Elcin Unal, Douglas E Koshland, Joseph L DeRisi, Jennifer L Gerton   +7 more
doaj   +1 more source

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies. [PDF]

, 2019
Cohesin complex disruption alters gene expression, and cohesin mutations are common in myeloid neoplasia, suggesting a critical role in hematopoiesis.
Green, Anthony R., Osborne, Cameron S., Evan, Theo, Papaemmanuil, Elli, Szybinski, Jakub, Russell, Nigel, Göttgens, Berthold, Huntly, Brian J.P., Yun, Haiyang, Gallipoli, Paolo, Giotopoulos, George, Wilson, Nicola K., Campbell, Peter, Hills, Robert, Sasca, Daniel, Gerstung, Moritz   +15 more
core   +3 more sources

Cohesin-Mediated Chromatin Interactions and Autoimmunity

Frontiers in Immunology, 2022
Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-
Venkataragavan Chandrasekaran, Nina Oparina, Maria-Jose Garcia-Bonete, Caroline Wasén, Caroline Wasén, Malin C. Erlandsson, Eric Malmhäll-Bah, Karin M. E. Andersson, Maja Jensen, Sofia T. Silfverswärd, Gergely Katona, Maria I. Bokarewa, Maria I. Bokarewa   +12 more
doaj   +1 more source

A unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation.

Molecules and Cells
The ring-shaped cohesin complex topologically entraps two DNAs to establish sister chromatid cohesion. Cohesin also shapes the interphase chromatin landscape by forming DNA loops, which it is thought to achieve using an in vitro-observed loop extrusion ...
F. Uhlmann
semanticscholar   +1 more source