Results 71 to 80 of about 18,597 (218)
Spo13 regulates cohesin cleavage [PDF]
, 2002 A key aspect of meiotic chromosome segregation is that cohesin, the protein complex that holds sister chromatids together, dissociates from chromosome arms during meiosis I and from centromeric regions during meiosis II.
Brian H. Lee +2 more
core +1 more source
Advanced Science, EarlyView.Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg +18 more
wiley +1 more source
The multifaceted roles of cohesin in cancer
Journal of Experimental & Clinical Cancer Research, 2022 AbstractThe cohesin complex controls faithful chromosome segregation by pairing sister chromatids after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and maintaining DNA integrity.
Di Nardo Maddalena +2 more
openaire +3 more sources
A single cohesin complex performs mitotic and meiotic functions in the protist tetrahymena.
PLoS Genetics, 2013 The cohesion of sister chromatids in the interval between chromosome replication and anaphase is important for preventing the precocious separation, and hence nondisjunction, of chromatids.
Rachel A Howard-Till +3 more
doaj +1 more source
Advanced Science, EarlyView.eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu +12 more
wiley +1 more source
Current Challenges of Transcription Compartmentalization Research
Advanced Science, EarlyView.Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley +1 more source
Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading
eLife, 2023 Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring.
Hayley Porter +12 more
doaj +1 more source
Myelodysplastic Syndromes: 2026 Update on Diagnosis, Risk‐Stratification and Management
American Journal of Hematology, EarlyView.ABSTRACT Disease Overview The myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous leukemia (AML). MDS occurs more frequently in older males and in individuals with prior exposure to cytotoxic therapy.
Guillermo Garcia‐Manero
wiley +1 more source
The Journal of Cell Biology, 2001 ![Graphic][1] Cohesin (red) keeps centromeres together. Peters/AAAS Cohesin was a long sought-after protein complex: a glue for sister chromatids that is dissolved at the onset of anaphase thanks to cleavage of its SCC1 subunit by the protease separase.
openaire +1 more source
Recent advances in cohesin biology [PDF]
F1000Research, 2016 Sister chromatids are tethered together from the time they are formed in S-phase until they separate at anaphase. A protein complex called cohesin is responsible for holding the sister chromatids together and serves important roles in chromosome condensation, gene regulation, and the repair of DNA damage.
Rankin, Susannah, Dawson, Dean S.
openaire +2 more sources