Results 71 to 80 of about 26,113 (251)

Human cohesin compacts DNA by loop extrusion

Science, 2019
Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al.
Yoori Kim, Zhu-Bing Shi, Hong-Shan Zhang, I. Finkelstein, Hong-Tao Yu   +4 more
semanticscholar   +1 more source

Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes [PDF]

, 2015
Wapl induces cohesin dissociation from DNA throughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure.
Castellano-Pozo, M, Jaso-Tamame, AL, Oliver Crawley, Crawley, Oliver, Barroso, Consuelo, Nuria Ferrandiz, Sarah Testori, Nicola Silva, Maikel Castellano-Pozo, Ferrandiz, N, Jaso-Tamame, Ángel Luis, Ferrándiz, Nuria, Angel Luis Jaso-Tamame, Martinez-Perez, E, Castellano-Pozo, Maikel, Silva, Nicola, Barroso, C, Testori, S, Martínez-Pérez, Enrique, Crawley, O, Enrique Martinez-Perez, Testori, Sarah, Consuelo Barroso, Silva, N   +23 more
core   +1 more source

Communication between distinct subunit interfaces of the cohesin complex promotes its topological entrapment of DNA

eLife, 2019
Cohesin mediates higher order chromosome structure. Its biological activities require topological entrapment of DNA within a lumen(s) formed by cohesin subunits.
Vincent Guacci, Fiona Chatterjee, Brett Robison, Douglas E Koshland   +3 more
doaj   +1 more source

Synergy between regulatory elements can render cohesin dispensable for distal enhancer function

Science
Enhancers are critical genetic elements controlling transcription from promoters, yet how they convey regulatory information across large genomic distances remains unclear.
Karissa L. Hansen, Annie S. Adachi, L. Braccioli, Smit Kadvani, Ryan M. Boileau, Moreno Martinovic, Bozhena Pokorny, Rini Shah, Erika C. Anderson, Kaite Zhang, Irié Carel, Kenya Bonitto, R. Blelloch, Geoffrey Fudenberg, Elzo de Wit, Elphѐge P. Nora   +15 more
semanticscholar   +1 more source

Two independent modes of chromatin organization revealed by cohesin removal

Nature, 2017
Imaging and chromosome conformation capture studies have revealed several layers of chromosome organization, including segregation into megabase-sized active and inactive compartments, and partitioning into sub-megabase domains (TADs). It remains unclear,
Wibke Schwarzer, Nezar Abdennur, A. Goloborodko, A. Pękowska, G. Fudenberg, Yann Loe-Mie, Nuno A. Fonseca, W. Huber, C. Haering, L. Mirny, F. Spitz   +10 more
semanticscholar   +1 more source

Cohesin forms fountains at active enhancers in C. elegans

Nature Communications
Transcriptional enhancers must locate target genes with precision. In mammals, topologically associating domains (TADs) guide this process, but the C. elegans genome lacks such organization despite containing over 30,000 putative enhancers.
Bolaji N. Lüthi, Jennifer I. Semple, Anja Haemmerli, Saurabh Thapliyal, Kalyan Ghadage, Klement Stojanovski, Dario D'Asaro, Moushumi Das, N. Gilbert, Dominique A. Glauser, B. Towbin, D. Jost, P. Meister   +12 more
semanticscholar   +1 more source

The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism

Nature Structural & Molecular Biology, 2022
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin’s SMC3 subunit is a dynamic process that involves the acetyltransferase ESCO1 and deacetylase HDAC8.
M. S. van Ruiten, Démi van Gent, Ángela Sedeño Cacciatore, Astrid Fauster, Laureen Willems, M. Hekkelman, L. Hoekman, M. Altelaar, J. Haarhuis, T. Brummelkamp, Elzo de Wit, B. Rowland   +11 more
semanticscholar   +1 more source

Regulation of the Drosophila Enhancer of split and invected-engrailed gene complexes by sister chromatid cohesion proteins.

PLoS ONE, 2009
The cohesin protein complex was first recognized for holding sister chromatids together and ensuring proper chromosome segregation. Cohesin also regulates gene expression, but the mechanisms are unknown.
Cheri A Schaaf, Ziva Misulovin, Gurmukh Sahota, Akbar M Siddiqui, Yuri B Schwartz, Tatyana G Kahn, Vincenzo Pirrotta, Maria Gause, Dale Dorsett   +8 more
doaj   +1 more source

Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks

Science Advances, 2022
Genome function depends on regulated chromosome folding, and loop extrusion by the protein complex cohesin is essential for this multilayered organization.
Kristian Jeppsson, Toyonori Sakata, Ryuichiro Nakato, Stefina Milanova, K. Shirahige, Camilla Björkegren   +5 more
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source