Results 91 to 100 of about 26,113 (251)

Irr1/Scc3 Cohesin Interacts with Rec8 in Meiotic Prophase of Saccharomyces cerevisiae [PDF]

, 2011
The meiotic cohesin complex of S. cerevisiae shares with the mitotic one the Irr1/Scc3, Smc1, and Smc3 subunits, while the meiosis-specific subunit Rec8 re-places mitotic subunit Scc1/Mcd1.
Cena, Agata, Kurlandzka, Anna, Agata Cena, Piotr Kowalec, Plochocka, Danuta, Danuta Płochocka, Kowalec, Piotr, Anna Kurl   +7 more
core  

Dalmatian:Spotting the difference in cohesin protectors [PDF]

, 2017
The cohesin complex prevents separation of chromosomes following their duplication until the appropriate time during cell division. In vertebrates, establishment and maintenance of cohesin-dependent linkages depend on two distinct proteins, sororin and ...
Adele L Marston, Marston, Adele L.
core   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.

PLoS Biology, 2005
Cohesin is a protein complex that is required to hold sister chromatids together. Cleavage of the Scc1 subunit of cohesin by the protease separase releases the complex from chromosomes and thereby enables the separation of sister chromatids in anaphase ...
Silke Hauf, Elisabeth Roitinger, Birgit Koch, Christina M Dittrich, Karl Mechtler, Jan-Michael Peters   +5 more
doaj   +1 more source

STAG2 promotes the myelination transcriptional program in oligodendrocytes

eLife, 2022
Cohesin folds chromosomes via DNA loop extrusion. Cohesin-mediated chromosome loops regulate transcription by shaping long-range enhancer–promoter interactions, among other mechanisms.
Ningyan Cheng, Guanchen Li, Mohammed Kanchwala, Bret M Evers, Chao Xing, Hongtao Yu   +5 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Enigmatic Ladies of the Rings: How Cohesin Dysfunction Affects Myeloid Neoplasms Insurgence

Frontiers in Cell and Developmental Biology, 2019
The genes of the cohesin complex exert different functions, ranging from the adhesion of sister chromatids during the cell cycle, DNA repair, gene expression and chromatin architecture remodeling.
Alex Pezzotta, Mara Mazzola, Marco Spreafico, Anna Marozzi, Anna Pistocchi   +4 more
doaj   +1 more source

Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML

Science Translational Medicine
Splicing modulation is a promising treatment strategy pursued to date only in splicing factor-mutant cancers; however, its therapeutic potential is poorly understood outside of this context. Like splicing factors, genes encoding components of the cohesin
Emily C. Wheeler, Benjamin J. E. Martin, William C. Doyle, Sofia Neaher, Caroline A. Conway, Caroline N. Pitton, Rebecca A. Gorelov, M. Donahue, Joahnn-Christoph Jann, Omar Abdel-Wahab, Justin Taylor, Michael Seiler, S. Buonamici, Y. Pikman, Jacqueline S. Garcia, R. Belizaire, Karen Adelman, Zuzana Tothova   +17 more
semanticscholar   +1 more source

Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner

eLife, 2020
Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been proposed as a mechanism to organize chromatin in interphase and metaphase. However, the requirements for chromatin organization in these cell cycle phases are different, and
Stefan Golfier, Thomas Quail, H. Kimura, Jan Brugués   +3 more
semanticscholar   +1 more source

Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

bioRxiv, 2022
Cohesin connects CTCF binding sites and other genomic loci in cis to form chromatin loops, and replicated DNA molecules in trans to mediate sister chromatid cohesion.
Kota Nagasaka, I. Davidson, Roman R. Stocsits, Wen Tang, G. Wutz, P. Betty, Mélanie Panarotto, Gabriele Litos, A. Schleiffer, D. Gerlich, J. Peters   +10 more
semanticscholar   +1 more source