Results 91 to 100 of about 14,462 (190)
Cancer, Volume 132, Issue 11, 1 June 2026.Abstract Background Mutations in cytokine receptor and JAK/STAT; Cy‐JAK/STAT) signaling genes drive myeloproliferative neoplasms (MPNs) but remain incompletely characterized in acute myeloid leukemia (AML). The authors evaluated the prevalence, clinical presentation, and prognostic significance of Cy‐JAK/STAT pathway mutations in patients with AML and ...
Moath Albliwi +22 more
wiley +1 more source
Multiplexed Retinoic Acid Signal Reporters for In Vivo and In Vitro Use
genesis, Volume 64, Issue 3, June 2026.ABSTRACT Here we describe the optimisation of a modular, generally applicable and rapid method to make multimerised signaling‐molecule reporters for detecting different retinoic acid concentrations. The technical plasmid design allows for the easy exchange of reporters, promoters, signal‐responsive elements as well as for the multimerization of entire ...
Craig Smith +4 more
wiley +1 more source
Interallelic complementation provides functional evidence for cohesin–cohesin interactions on DNA
Molecular Biology of the Cell, 2015 The cohesin complex (Mcd1p, Smc1p, Smc3p, and Scc3p) has multiple roles in chromosome architecture, such as promoting sister chromatid cohesion, chromosome condensation, DNA repair, and transcriptional regulation. The prevailing embrace model for sister chromatid cohesion posits that a single cohesin complex entraps both sister chromatids.
Eng, Thomas +2 more
openaire +4 more sources
Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.
PLoS Genetics, 2018 The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B-Mau2 protein complex
Ziva Misulovin +3 more
doaj +1 more source
A new meiosis‐specific cohesin complex implicated in the cohesin code for homologous pairing
EMBO reports, 2011 We identify a new mammalian cohesin subunit, RAD21‐like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21.
Ishiguro, Kei-ichiro +4 more
openaire +2 more sources
Plant Direct, Volume 10, Issue 6, June 2026.ABSTRACT Bicellular pollen often enters a desiccated state wherein development is temporarily arrested, enabling long‐term survival while maintaining the capacity for rapid activation upon hydration. Although the generative cell in mature pollen of Lilium species is known to have completed DNA replication, its precise cell‐cycle status and the ...
Mio K. Shibuta +2 more
wiley +1 more source
Pitfalls and missing links in current understanding of 4D genomes
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract The spatial and temporal organization of the genome—collectively termed the 4D genome—is pivotal for regulating gene expression, maintaining genome stability, and guiding development. The convergence of chromosome conformation capture technologies, super‐resolution microscopy, and single‐cell epigenomics has transformed our understanding of ...
Michael Q. Zhang
wiley +1 more source
Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.
PLoS ONE, 2014 High fidelity chromosome segregation during mitosis requires that cells identify the products of DNA replication during S-phase and then maintain that identity until anaphase onset.
Kevin Tong, Robert V Skibbens
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SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis
Cell Proliferation, Volume 59, Issue 6, June 2026.The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu +16 more
wiley +1 more source
Taking cohesin and condensin in context
PLOS Genetics, 2018 Structural maintenance of chromosome (SMC) protein complexes, including cohesin and condensin, are increasingly being recognized for their important role in cancer and development, making it critical that we understand how these evolutionarily conserved multi-subunit protein complexes associate with and organize the genome.
Kobe C. Yuen, Jennifer L. Gerton
openaire +3 more sources