Results 91 to 100 of about 18,597 (218)
The FEBS Journal, EarlyView.Homologous recombination (HR) in Schizosaccharomyces pombe is essential when mating‐type switching–induced double‐strand breaks (DSBs) form at the mat1 locus. In h90 and h− strains, efficient mat1 DSB formation renders HR indispensable unless suppressors block these breaks.
Peter Kolesar +3 more
wiley +1 more source
Cohesin Mutations in Myeloid Malignancies [PDF]
Trends in Cancer, 2017 Acute Myeloid Leukemia (AML) is a hematologic malignancy with a poor prognosis. Recent genome-wide sequencing studies have identified frequent mutations in genes encoding members of the cohesin complex. Mutations in cohesin contribute to myeloid malignancies by conferring enhanced self-renewal of hematopoietic stem and progenitor cells but the ...
Joseph B, Fisher +4 more
openaire +2 more sources
, 2014 (A) Overlapping peaks of cohesin binding in cells with or without stimulation. Venn diagrams depict unique and common binding sites for cohesin in three different ChIP conditions based on 3 replicates, each using purified B cells pooled from 12 mice ...
Maciej Paszkowski-Rogacz (88226) +5 more
core +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1821-1831, August 2026.ABSTRACT There is a strong genetic contribution to the etiology of congenital diaphragmatic hernia (CDH). This study evaluated genetic testing results and diagnostic yield for fetuses and children with CDH. This was a retrospective cohort study of exome sequencing (ES) performed at GeneDx for fetuses and children ≤ 18 years of age with CDH compared ...
Justin Blair +9 more
wiley +1 more source
Epigenetics & ChromatinBackground Cohesin is a major regulator of three-dimensional genome organization and gene expression. Cohesin associates with DNA and dynamically extrudes a DNA loop, often bringing two cis-regulatory elements physically close together. Extruding cohesin
Audra F. Bryan +4 more
doaj +1 more source
RAD21 is the core subunit of the cohesin complex involved in directing genome organization
Genome Biology, 2023 Background The ring-shaped cohesin complex is an important factor for the formation of chromatin loops and topologically associating domains (TADs) by loop extrusion.
Yuao Sun +16 more
doaj +1 more source
Evolution of N‐terminal mechanical lability as a determinant for Type III secretion
Protein Science, Volume 35, Issue 8, August 2026.Abstract Many Gram‐negative pathogens critically depend on the Type III secretion system (T3SS) to inject effector proteins into host cells for colonization. Because the channel of the T3SS is narrow (~2 nm), effectors must be unfolded for secretion.
Katherine E. DaPron +7 more
wiley +1 more source
Cohesin mutations in human cancer [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2016 Cohesin is a highly-conserved protein complex that plays important roles in sister chromatid cohesion, chromatin structure, gene expression, and DNA repair. In humans, cohesin is a ubiquitously expressed, multi-subunit protein complex composed of core subunits SMC1A, SMC3, RAD21, STAG1/2 and regulatory subunits WAPL, PDS5A/B, CDCA5, NIPBL, and MAU2 ...
Victoria K, Hill +2 more
openaire +2 more sources
Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
Three cohesin-PcG states and their interactions. [PDF]
, 2013 In the PcG-silenced state (left), PRC1 (green rectangle) and PRC2 (tan rectangle) are both present, and the target genes are marked by the H3K27me3 histone modification made by PRC2.
Ziva Misulovin (262237) +6 more
core +1 more source