Results 101 to 110 of about 18,597 (218)
eLifeThe cohesin complex maintains sister chromatid cohesion from S phase to anaphase onset. Cohesin also plays roles in chromosome structure and DNA repair.
Jessel Ayra Plasencia +5 more
doaj +1 more source
Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.
PLoS Genetics, 2009 Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion by connecting replicated DNA molecules. Cohesin also has important roles in gene regulation, but the mechanistic basis of this function is poorly understood.
Raffaella Nativio +9 more
doaj +1 more source
Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits
Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.ABSTRACT Transposable elements (TEs) constitute nearly half of the human genome and are increasingly recognized as context‐dependent regulators of genome function rather than passive repetitive DNA. This Review synthesizes classical and recent evidence on TE biology, including TE classification, mechanisms of mobilization, host restriction pathways ...
Irving Jesús Reyes‐Barragán
wiley +1 more source
The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering
eLife, 2015 Cohesin tethers together regions of DNA, thereby mediating higher order chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptional regulation. Cohesin contains a heterodimeric ATP-binding Cassette (ABC) ATPase comprised of Smc1 and Smc3 ATPase active sites.
Gamze Çamdere +3 more
openaire +3 more sources
Cohesin: A guardian of genome integrity [PDF]
, 2012 Ability to reproduce is one of the hallmark features of all life forms by which new organisms are produced from their progenitors. During this process each cell duplicates its genome and passes a copy of its genome to the daughter cells along with the ...
Mehta, Gunjan D. +2 more
core +1 more source
Inflammatory signatures in the spectrum of myeloid diseases
HemaSphere, Volume 10, Issue 7, July 2026.Abstract Dysregulated innate immunity contributes to clonal cytopenias and myeloid neoplasms, but its extent across disease stages and clinical relevance remain incompletely defined. We analyzed plasma ASC/NLRP3 double‐positive (DP) specks, ASC single‐positive (SP) specks, and 45 cytokines in 223 patients with idiopathic cytopenias of undetermined ...
Alice Ibbotson +12 more
wiley +1 more source
Cohesin interaction with centromeric minichromosomes shows a multi-complex rod-shaped structure.
PLoS ONE, 2008 Cohesin is the protein complex responsible for maintaining sister chromatid cohesion. Cohesin interacts with centromeres and specific loci along chromosome arms known as Chromosome Attachment Regions (CARs). The cohesin holocomplex contains four subunits.
Alexandra Surcel +3 more
doaj +1 more source
Protein Science, Volume 35, Issue 7, July 2026.Abstract Cellulosomes are multi‐enzyme assemblies whose catalytic efficiency depends on the spatial organization of their components. However, their pronounced conformational flexibility has precluded quantitative characterization of inter‐enzyme distances and overall topology.
Iker Pardo Larrabeiti +11 more
wiley +1 more source
Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.
PLoS Genetics, 2018 The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B-Mau2 protein complex
Ziva Misulovin +3 more
doaj +1 more source
Interallelic complementation provides functional evidence for cohesin–cohesin interactions on DNA
Molecular Biology of the Cell, 2015 The cohesin complex (Mcd1p, Smc1p, Smc3p, and Scc3p) has multiple roles in chromosome architecture, such as promoting sister chromatid cohesion, chromosome condensation, DNA repair, and transcriptional regulation. The prevailing embrace model for sister chromatid cohesion posits that a single cohesin complex entraps both sister chromatids.
Eng, Thomas +2 more
openaire +4 more sources