Results 101 to 110 of about 26,113 (251)

Cohesin is involved in circadian interactome.

, 2016
(a) The COGs in mouse liver interacting with the enhancer at CT6 or CT18. Their circadian phases and distances to the bait were listed. (b) The enhancer interacting regions significantly overlap more with the binding sites of cohesin-non-CTCF than ...
Meng Zhao (54299), Yan Zhang (8098), Zhihu Zhao (185759), Yichi Xu (2634916), Zenghua Fan (2634913), Jun Yan (28467), Weimin Guo (2634919), Ping Li (31981)   +7 more
core   +1 more source

A single cohesin complex performs mitotic and meiotic functions in the protist tetrahymena.

PLoS Genetics, 2013
The cohesion of sister chromatids in the interval between chromosome replication and anaphase is important for preventing the precocious separation, and hence nondisjunction, of chromatids.
Rachel A Howard-Till, Agnieszka Lukaszewicz, Maria Novatchkova, Josef Loidl   +3 more
doaj   +1 more source

The multifaceted roles of cohesin in cancer

Journal of Experimental & Clinical Cancer Research, 2022
AbstractThe cohesin complex controls faithful chromosome segregation by pairing sister chromatids after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and maintaining DNA integrity.
Di Nardo Maddalena, Pallotta Maria M, Musio Antonio   +2 more
openaire   +3 more sources

An extrinsic motor directs chromatin loop formation by cohesin

EMBO Journal
The ring-shaped cohesin complex topologically entraps two DNA molecules to establish sister chromatid cohesion. Cohesin also shapes the interphase chromatin landscape with wide-ranging implications for gene regulation, and cohesin is thought to achieve ...
Thomas M. Guérin, Christopher Barrington, Georgii Pobegalov, M. Molodtsov, F. Uhlmann   +4 more
semanticscholar   +1 more source

CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function together to establish chromatin loops and regulate gene expression in mammalian cells.
E. Pugacheva, Naoki Kubo, D. Loukinov, Md Tajmul, S. Kang, A. Kovalchuk, A. Strunnikov, G. Zentner, B. Ren, Victor V Lobanenkov   +9 more
semanticscholar   +1 more source

CTCF-CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity

Nature Cell Biology, 2022
The ring-like cohesin complex mediates sister-chromatid cohesion by encircling pairs of sister chromatids. Cohesin also extrudes loops along chromatids. Whether the two activities involve similar mechanisms of DNA engagement is not known.
Yu Liu, J. Dekker
semanticscholar   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Depletion or cleavage of cohesin during anaphase differentially affects chromatin structure and segregation

eLife, 2022
Chromosome segregation requires both the separation of sister chromatids and the sustained condensation of chromatids during anaphase. In yeast cells, cohesin is not only required for sister chromatid cohesion but also plays a major role determining the ...
Jonay Garcia-Luis, Hélène Bordelet, Agnès Thierry, Romain Koszul, Luis Aragon   +4 more
doaj   +1 more source

Landscape of cohesin-mediated chromatin loops in the human genome

Nature, 2020
Physical interactions between distal regulatory elements have a key role in regulating gene expression, but the extent to which these interactions vary between cell types and contribute to cell-type-specific gene expression remains unclear.
F. Grubert, R. Srivas, D. Spacek, Maya M Kasowski, Mariana Ruiz-Velasco, N. Sinnott-Armstrong, Peyton Greenside, A. Narasimha, Qing Liu, Benjamin S. Geller, A. Sanghi, M. Kulik, S. Sa, M. Rabinovitch, A. Kundaje, S. Dalton, J. Zaugg, Michael P. Snyder   +17 more
semanticscholar   +1 more source

Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF

Nature Communications, 2021
Enhancers and promoters predominantly interact within large-scale topologically associating domains (TADs), which are formed by loop extrusion mediated by cohesin and CTCF. However, it is unclear whether complex chromatin structures exist at sub-kilobase-
Abrar Aljahani, P. Hua, Magdalena A. Karpińska, Kimberly Quililan, J. Davies, A. M. Oudelaar   +5 more
semanticscholar   +1 more source