Results 121 to 130 of about 26,113 (251)
Journal of Integrative Plant Biology, EarlyView.This review decodes the grammar of plant cis‐regulatory elements, revealing that their function emerges from sequence, chromatin accessibility, 3D topology, and cell type context. It highlights how single‐cell omics, CRISPR dissection, and AI‐driven design converge to enable predictive engineering and crop improvement. ABSTRACT Cis‐regulatory elements (
Libin Zhang, Maoteng Li
wiley +1 more source
New Phytologist, EarlyView.Ancestral lifestyle reconstruction across the phylogeny of the 107 analysed fungal genomes. Summary Dark septate endophytes (DSE) are widespread root‐colonising fungi with poorly understood lifestyle and ecological functions. We investigated their genomic traits, sexual reproduction signatures, carbohydrate‐active enzyme (CAZyme) and secondary ...
Sándor Csíkos +16 more
wiley +1 more source
Epigenetics & ChromatinBackground Cohesin is a major regulator of three-dimensional genome organization and gene expression. Cohesin associates with DNA and dynamically extrudes a DNA loop, often bringing two cis-regulatory elements physically close together. Extruding cohesin
Audra F. Bryan +4 more
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WAPL maintains a cohesin loading cycle to preserve cell-type specific distal gene regulation
Nature Genetics, 2020 The cohesin complex has an essential role in maintaining genome organization. However, its role in gene regulation remains largely unresolved. Here we report that the cohesin release factor WAPL creates a pool of free cohesin, in a process known as ...
N. Liu +8 more
semanticscholar +1 more source
Cohesin Mutations in Myeloid Malignancies [PDF]
Trends in Cancer, 2017 Acute Myeloid Leukemia (AML) is a hematologic malignancy with a poor prognosis. Recent genome-wide sequencing studies have identified frequent mutations in genes encoding members of the cohesin complex. Mutations in cohesin contribute to myeloid malignancies by conferring enhanced self-renewal of hematopoietic stem and progenitor cells but the ...
Joseph B, Fisher +4 more
openaire +2 more sources
Multifaceted roles of cohesin.
, 2016 Cohesin functions are separable through cell cycle (red: mitotic; green: interphase) and genetic manipulations. For instance, mutation of RAD61 suppresses only condensation defects, while mutation of ELG1 (mimicking overexpression of PCNA) suppresses ...
Robert V. Skibbens (238808)
core +1 more source
Single‐Nucleus Transcriptome Analysis Provides New Insights Into B Chromosome Elimination in Sorghum
Plant Biotechnology Journal, EarlyView.ABSTRACT B chromosomes are supernumerary entities found in many plant species, with some exhibiting tissue‐specific elimination. In Sorghum purpureosericeum, extensive B chromosome elimination occurs during embryogenesis affecting most of the embryonic organs, leaving the B chromosome maintained mainly in limited regions of meristems.
T. Bojdová +4 more
wiley +1 more source
Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.Long non‐coding RNAs (lncRNAs) act as key regulators of economically important traits in livestock through diverse mechanisms including ceRNA networks, epigenetic regulation (X‐inactivation and imprinting) and liquid–liquid phase separation (LLPS).
Keyvan Khani +2 more
wiley +1 more source
A multi-step pathway for the establishment of sister chromatid cohesion.
PLoS Genetics, 2007 The cohesion of sister chromatids is mediated by cohesin, a protein complex containing members of the structural maintenance of chromosome (Smc) family. How cohesins tether sister chromatids is not yet understood.
Mark Milutinovich +4 more
doaj +1 more source
Nature Communications, 2023 The ring-shaped cohesin complex is a key player in sister chromatid cohesion, DNA repair, and gene transcription. The loading of cohesin to chromosomes requires the loader Scc2 and is regulated by ATP.
Aditi Kaushik +8 more
doaj +1 more source