Results 131 to 140 of about 26,113 (251)

Cohesin mutations in human cancer [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2016
Cohesin is a highly-conserved protein complex that plays important roles in sister chromatid cohesion, chromatin structure, gene expression, and DNA repair. In humans, cohesin is a ubiquitously expressed, multi-subunit protein complex composed of core subunits SMC1A, SMC3, RAD21, STAG1/2 and regulatory subunits WAPL, PDS5A/B, CDCA5, NIPBL, and MAU2 ...
Victoria K, Hill, Jung-Sik, Kim, Todd, Waldman   +2 more
openaire   +2 more sources

Genome Aging in Women: Hematopoietic Loss of X Chromosome as An Exemplar

Aging Cell, Volume 25, Issue 11, November 2026.
As studies at the intersection of genetics and aging are rapidly advancing, genome aging provides a novel mechanism by which aging phenotypes occur. In this Review, the authors examine the rise, expansion, and the consequences of X chromosome loss in female blood cells.
Xihan Guo, Xueqin Dai
wiley   +1 more source

Interallelic complementation provides functional evidence for cohesin–cohesin interactions on DNA

Molecular Biology of the Cell, 2015
The cohesin complex (Mcd1p, Smc1p, Smc3p, and Scc3p) has multiple roles in chromosome architecture, such as promoting sister chromatid cohesion, chromosome condensation, DNA repair, and transcriptional regulation. The prevailing embrace model for sister chromatid cohesion posits that a single cohesin complex entraps both sister chromatids.
Eng, Thomas, Guacci, Vincent, Koshland, Douglas   +2 more
openaire   +4 more sources

A YAP–TEAD–CTCF Transcriptional Regulatory Axis Associated With the Elimination of Injured Hepatocytes From the Liver

Genes to Cells, Volume 31, Issue 6, November 2026.
Injured YAP‐activated hepatocytes are eliminated from the liver. They are extruded toward the sinusoidal lumen, undergo cell death, and are phagocytosed by macrophages. Here, we performed proximity ligation assay, ATAC‐seq, RNA‐seq, and CellChat analyses.
Daiki Hatakeyama, Yoshimi Okamoto‐Uchida, Misaki Kosaka, Haruka Hirose, Satoshi Kofuji, Keiko Danzaki, Yoshiki Endo, Michiko Nakagawa, Akinori Kanai, Yutaka Suzuki, Takeshi Yokoo, Shuji Terai, Teppei Shimamura, Hiroshi Nishina   +13 more
wiley   +1 more source

The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering

eLife, 2015
Cohesin tethers together regions of DNA, thereby mediating higher order chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptional regulation. Cohesin contains a heterodimeric ATP-binding Cassette (ABC) ATPase comprised of Smc1 and Smc3 ATPase active sites.
Gamze Çamdere, Vincent Guacci, Jeremiah Stricklin, Douglas Koshland   +3 more
openaire   +3 more sources

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.

PLoS Genetics, 2009
Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion by connecting replicated DNA molecules. Cohesin also has important roles in gene regulation, but the mechanistic basis of this function is poorly understood.
Raffaella Nativio, Kerstin S Wendt, Yoko Ito, Joanna E Huddleston, Santiago Uribe-Lewis, Kathryn Woodfine, Christel Krueger, Wolf Reik, Jan-Michael Peters, Adele Murrell   +9 more
doaj   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, Volume 13, Issue 52, 18 September 2026.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Cohesin reconstitution and homologous recombination repair of DNA double-strand breaks in late mitosis

eLife
The cohesin complex maintains sister chromatid cohesion from S phase to anaphase onset. Cohesin also plays roles in chromosome structure and DNA repair.
Jessel Ayra Plasencia, Sara Medina-Suárez, Esperanza Hernández-Carralero, Jonay García-Luis, Lorraine S Symington, Félix Machín   +5 more
doaj   +1 more source

Cohesin interaction with centromeric minichromosomes shows a multi-complex rod-shaped structure.

PLoS ONE, 2008
Cohesin is the protein complex responsible for maintaining sister chromatid cohesion. Cohesin interacts with centromeres and specific loci along chromosome arms known as Chromosome Attachment Regions (CARs). The cohesin holocomplex contains four subunits.
Alexandra Surcel, Douglas Koshland, Hong Ma, Robert T Simpson   +3 more
doaj   +1 more source