Results 111 to 120 of about 18,597 (218)
A new meiosis‐specific cohesin complex implicated in the cohesin code for homologous pairing
The EMBO Reports, 2011 We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21.
Ishiguro, Kei-ichiro +4 more
openaire +2 more sources
The specific roles of cohesin-SA1 and cohesin-SA2 in gene regulation and genome organization [PDF]
, 2018 Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura:13-07-2018The use of Chromosome Conformation Capture (3C)-derived techniques for probing 3D genome structure ...
Kojic, Aleksandar
core
, 2013 DSB data are shown in red, Rec8 data in black, and Mcd1 data in grey. (A) Ratios for meiotic cohesin are compared to mitotic cohesin in SK1 for kilobasepairs 440–461 on Chromosome XII.
Jennifer L Gerton (26655) +7 more
core +1 more source
Cohesin biology meets the loop extrusion model [PDF]
, 2017 Extensive research has revealed that cohesin acts as a topological device, trapping chromosomal DNA within a large tripartite ring. In so doing, cohesin contributes to the formation of compact and organized genomes.
Suzana Hadjur +5 more
core +1 more source
Multifaceted roles of cohesin. [PDF]
, 2016 Cohesin functions are separable through cell cycle (red: mitotic; green: interphase) and genetic manipulations. For instance, mutation of RAD61 suppresses only condensation defects, while mutation of ELG1 (mimicking overexpression of PCNA) suppresses ...
Robert V. Skibbens (238808)
core +1 more source
Absolute quantification of cohesin, CTCF and their regulators in human cells
eLife, 2019 The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. TADs and many loops are formed by cohesin and positioned by CTCF. In proliferating cells,
Johann Holzmann +16 more
doaj +1 more source
Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.
PLoS ONE, 2014 High fidelity chromosome segregation during mitosis requires that cells identify the products of DNA replication during S-phase and then maintain that identity until anaphase onset.
Kevin Tong, Robert V Skibbens
doaj +1 more source
Taking cohesin and condensin in context
PLOS Genetics, 2018 Structural maintenance of chromosome (SMC) protein complexes, including cohesin and condensin, are increasingly being recognized for their important role in cancer and development, making it critical that we understand how these evolutionarily conserved multi-subunit protein complexes associate with and organize the genome.
Kobe C. Yuen, Jennifer L. Gerton
openaire +3 more sources
Dalmatian:Spotting the difference in cohesin protectors [PDF]
, 2017 The cohesin complex prevents separation of chromosomes following their duplication until the appropriate time during cell division. In vertebrates, establishment and maintenance of cohesin-dependent linkages depend on two distinct proteins, sororin and ...
Adele L Marston, Marston, Adele L.
core +1 more source
Clinical Epigenetics, 2017 Background Cornelia de Lange syndrome (CdLS) is a multisystem developmental disorder frequently associated with heterozygous loss-of-function mutations of Nipped-B-like (NIPBL), the human homolog of Drosophila Nipped-B. NIPBL loads cohesin onto chromatin.
Daniel A. Newkirk +11 more
doaj +1 more source