Results 111 to 120 of about 26,113 (251)

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

The glucocorticoid receptor associates with the cohesin loader NIPBL to promote long-range gene regulation

Science Advances, 2022
The cohesin complex is central to chromatin looping, but mechanisms by which these long-range chromatin interactions are formed and persist remain unclear.
Lorenzo Rinaldi, Gregory Fettweis, Sohyoung Kim, David A. Garcia, Saori Fujiwara, T. A. Johnson, T. Tettey, L. Ozbun, Gianluca Pegoraro, M. Puglia, Blagoy Blagoev, A. Upadhyaya, D. Stavreva, G. Hager   +13 more
semanticscholar   +1 more source

Cohesin's cohesion [PDF]

The Journal of Cell Biology, 2001
![Graphic][1] Cohesin (red) keeps centromeres together. Peters/AAAS Cohesin was a long sought-after protein complex: a glue for sister chromatids that is dissolved at the onset of anaphase thanks to cleavage of its SCC1 subunit by the protease separase.
openaire   +1 more source

Recent advances in cohesin biology [PDF]

F1000Research, 2016
Sister chromatids are tethered together from the time they are formed in S-phase until they separate at anaphase. A protein complex called cohesin is responsible for holding the sister chromatids together and serves important roles in chromosome condensation, gene regulation, and the repair of DNA damage.
Rankin, Susannah, Dawson, Dean S.
openaire   +2 more sources

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Cohesin complex-associated holoprosencephaly [PDF]

Brain, 2019
AbstractMarked by incomplete division of the embryonic forebrain, holoprosencephaly is one of the most common human developmental disorders. Despite decades of phenotype-driven research, 80–90% of aneuploidy-negative holoprosencephaly individuals with a probable genetic aetiology do not have a genetic diagnosis.
Kruszka, P., Berger, S.I., Casa, V., Dekker, M.R., Gaesser, J., Weiss, K., Martinez, A.F., Murdock, D.R., Louie, R.J., Prijoles, E.J., Lichty, A.W., Brouwer, O.F., Zonneveld-Huijssoon, E., Stephan, M.J., Hogue, J., Hu, P., Tanima-Nagai, M., Everson, J.L., Prasad, C., Cereda, A., Iascone, M., Schreiber, A., Zurcher, V., Corsten-Janssen, N., Escobar, L., Clegg, N.J., Delgado, M.R., Hajirnis, O., Balasubramanian, M., Kayserili, H., Deardorff, M., Poot, R.A., Wendt, K.S., Lipinski, R.J., Muenke, M.   +34 more
openaire   +7 more sources

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

Cohesin positions the epigenetic reader Phf2 within the genome

The EMBO Journal
Genomic DNA is assembled into chromatin by histones, and extruded into loops by cohesin. These mechanisms control important genomic functions, but whether histones and cohesin cooperate in genome regulation is poorly understood.
Wen Tang, Lorenzo Costantino, Roman Stocsits, Gordana Wutz, Rene Ladurner, Otto Hudecz, Karl Mechtler, Jan-Michael Peters   +7 more
doaj   +1 more source

FACT mediates cohesin function on chromatin [PDF]

, 2019
Cohesin is a regulator of genome architecture with roles in sister chromatid cohesion and chromosome compaction. The recruitment and mobility of cohesin complexes on DNA is restricted by nucleosomes.
Gutiérrez-Escribano, Pilar, Lazar-Stefanita, Luciana, Sara González, Pilar Gutierrez-Escribano, Alicia García, Dore, Marian, Karimi, Mohammad M., González-Arranz, Sara, Antequera, Francisco, Romain Koszul, Luis Aragon, García, Alicia, García-Luis, Jonay, Thierry, Agnes, Luciana Lazar-Stefanita, Francisco Antequera, Gonzalez, Sara, Marian Dore, Adam Jarmuz, Karimi, Mohammad M.; id_orcid, Agnes Thierry, Jarmuz, Adam, Montoya, Alex, Mar Sánchez, Sánchez, Mar, Aragón, Luis, Jonay Garcia-Luis, Mohammad M. Karimi, Karimi, Mohammad, Holger Kramer, Koszul, Romain, Alex Montoya, Axel Cournac, Cournac, Axel, Kramer, Holger, García Martínez, Alicia   +35 more
core   +1 more source