Biochemical Reconstitution of Sister Chromatid Cohesion Establishment During DNA Replication [PDF]
Molecular CellConcomitant with DNA replication, the ring-shaped cohesin complex encircles both newly synthesized sister chromatids, enabling their faithful segregation during cell divisions.
John Diffley +2 more
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Towards a Structural Mechanism for Sister Chromatid Cohesion Establishment at the Eukaryotic Replication Fork [PDF]
Biology, 2021 Cohesion between replicated chromosomes is essential for chromatin dynamics and equal segregation of duplicated genetic material. In the G1 phase, the ring-shaped cohesin complex is loaded onto duplex DNA, enriching at replication start sites, or ...
Sarah S. Henrikus, Alessandro Costa
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Chromatin assembly factor-1 preserves genome stability in ctf4∆ cells by promoting sister chromatid cohesion [PDF]
Cell Stress, 2023 Chromatin assembly and the establishment of sister chromatid cohesion are intimately connected to the progression of DNA replication forks. Here we examined the genetic interaction between the heterotrimeric chromatin assembly factor-1 (CAF-1), a central
Nagham Ghaddar +3 more
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Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion [PDF]
Nature Communications, 2020 WABS patient derived cells display loss of sister chromatid cohesion. Here the authors by analyzing WABS patient derived cells, reveal a role of the DDX11 helicase in resolving G-Quadruplex structures to support sister chromatid cohesion.
Janne J. M. van Schie +18 more
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Hsp90 Is Essential for Chl1-Mediated Chromosome Segregation and Sister Chromatid Cohesion [PDF]
mSphere, 2018 Recent studies have demonstrated that aberrant sister chromatid cohesion causes genomic instability and hence is responsible for the development of a tumor.
Nidhi Khurana +4 more
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A non-canonical role of the inner kinetochore in regulating sister-chromatid cohesion at centromeres [PDF]
The EMBO JournalThe 16-subunit Constitutive Centromere-associated Network (CCAN)-based inner kinetochore is well-known for connecting centromeric chromatin to the spindle-binding outer kinetochore.
Lu Yan +12 more
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S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion [PDF]
The EMBO JournalSororin is essential for establishing sister chromatid cohesion concurrently with DNA replication in metazoans. Although acetylation of the cohesin subunit SMC3 by ESCO1/2 is necessary for Sororin recruitment, it is by itself not sufficient.
Meiqian Jiang +15 more
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Sororin locks the DNA-exit gate of cohesin to preserve sister-chromatid cohesion [PDF]
Nature CommunicationsThe cohesin complex mediates sister-chromatid cohesion by topologically entrapping DNA within an SMC1-SMC3-RAD21 ring, yet how Sororin preserves cohesion beyond its known role of antagonizing Pds5 binding to the release factor Wapl has remained unclear ...
Qinfu Chen +7 more
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SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis [PDF]
Nature Communications, 2019 During cell division, Soronin antagonises WAPL to prevent premature loss of sister chromatid cohesion. Here the authors show that, despite a lack of sequence similarity, the Arabidopsis SWI1 protein functions as a novel Soronin-like WAPL antagonist ...
Chao Yang +6 more
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Multivalent Interaction of ESCO2 With the Replication Machinery Is Required for Sister Chromatid Cohesion in Vertebrates [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Jingrong Chen, Susannah Rankin
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