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Handcuff for sisters: A new model for sister chromatid cohesion [PDF]

open access: yesCell Cycle, 2009
High fidelity chromosome transmission requires the pairing of sister chromatids by a group of conserved proteins called cohesins during S-phase. Sister chromatid cohesion is maintained until anaphase onset. Presently, there are two sets of models of cohesin complex popular in the cohesin biology field: one model predicts that single cohesin rings ...
Nenggang, Zhang, Debananda, Pati
openaire   +2 more sources

Mechanics of Sister Chromatids studied with a Polymer Model

open access: yesFrontiers in Physics, 2013
Sister chromatid cohesion denotes the phenomenon that sister chromatids are initially attached to each other in mitosis to guarantee the error-free distribution into the daughter cells.
Yang eZhang   +3 more
doaj   +1 more source

Establishment of Sister Chromatid Cohesion [PDF]

open access: yesCurrent Biology, 2009
The process of sister chromatid pairing, or cohesion establishment, is coupled to DNA replication and fundamental to proper chromosome segregation and cell viability. In the past year, several articles have provided important new insights into cohesion establishment, an activity predicated on the acetyltransferase Ctf7/Eco1. Here, I review new findings
openaire   +2 more sources

LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion.

open access: yesPLoS Biology, 2012
Successful execution of the meiotic program depends on the timely establishment and removal of sister chromatid cohesion. LAB-1 has been proposed to act in the latter by preventing the premature removal of the meiosis-specific cohesin REC-8 at metaphase ...
Yonatan B Tzur   +7 more
doaj   +1 more source

Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.

open access: yesPLoS Genetics, 2018
The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B-Mau2 protein complex
Ziva Misulovin   +3 more
doaj   +1 more source

Function and mechanism of cohesin REC8 during meiosis

open access: yes浙江大学学报. 农业与生命科学版, 2023
Cohesin is a functionally and evolutionarily conserved multi-subunit protein complex that is required for sister chromatid cohesion and chromatin loop structure in both mitosis and meiosis. The meiotic cell-cycle consisting of one DNA replication and two
DAI Jingling, YU Chao
doaj   +1 more source

In Favor of Establishment: Regulation of Chromatid Cohesion in Plants

open access: yesFrontiers in Plant Science, 2017
In eukaryotic organisms, the correct regulation of sister chromatid cohesion, whereby sister chromatids are paired and held together, is essential for accurate segregation of the sister chromatids and homologous chromosomes into daughter cells during ...
Pablo Bolaños-Villegas   +4 more
doaj   +1 more source

The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. [PDF]

open access: yesPLoS Genetics, 2010
The DNA replication process represents a source of DNA stress that causes potentially spontaneous genome damage. This effect might be strengthened by mutations in crucial replication factors, requiring the activation of DNA damage checkpoints to enable ...
Naoki Takahashi   +9 more
doaj   +1 more source

Folding of cohesin’s coiled coil is important for Scc2/4-induced association with chromosomes

open access: yeseLife, 2021
Cohesin’s association with and translocation along chromosomal DNAs depend on an ATP hydrolysis cycle driving the association and subsequent release of DNA. This involves DNA being ‘clamped’ by Scc2 and ATP-dependent engagement of cohesin’s Smc1 and Smc3
Naomi J Petela   +13 more
doaj   +1 more source

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