Results 31 to 40 of about 921,868 (189)

The cohesin ring concatenates sister DNA molecules [PDF]

open access: yes, 2008
Sister chromatid cohesion, which is essential for mitosis, is mediated by a multi-subunit protein complex called cohesin whose Scc1, Smc1, and Smc3 subunits form a tripartite ring structure.
Arumugam, P   +9 more
core   +1 more source

Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]

open access: yes, 2014
Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Vázquez-Novelle, María Dolores   +6 more
core   +1 more source

Chromatid Cohesion: Acetylation Joins the Sisters [PDF]

open access: yesCurrent Biology, 2008
The replication-fork-associated protein Eco1 is required for the establishment of sister chromatid cohesion, which plays an essential role in faithful chromosome segregation. Three recent studies in yeast and humans reveal that the acetyltransferase activity of Eco1 targets the cohesin subunit Smc3 to facilitate the establishment of cohesion.
Tanaka, Koichi, Watanabe, Yoshinori
openaire   +2 more sources

Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2

open access: yesLife Science Alliance, 2020
This study reveals a role for the cohesin modifier ESCO2 for maintenance of sister chromatid cohesion in mammalian meiosis and a specific weakness of cohesion within male sex chromosome chromatin In mitotic cells, establishment of sister chromatid ...
François McNicoll   +6 more
doaj   +1 more source

Meiosis-specific cohesin complexes display essential and distinct roles in mitotic embryonic stem cell chromosomes

open access: yesGenome Biology, 2022
Background Cohesin is a chromosome-associated SMC–kleisin complex that mediates sister chromatid cohesion, recombination, and most chromosomal processes during mitosis and meiosis.
Eui-Hwan Choi   +7 more
doaj   +1 more source

Handcuff for sisters: A new model for sister chromatid cohesion [PDF]

open access: yesCell Cycle, 2009
High fidelity chromosome transmission requires the pairing of sister chromatids by a group of conserved proteins called cohesins during S-phase. Sister chromatid cohesion is maintained until anaphase onset. Presently, there are two sets of models of cohesin complex popular in the cohesin biology field: one model predicts that single cohesin rings ...
Nenggang, Zhang, Debananda, Pati
openaire   +2 more sources

Mechanics of Sister Chromatids studied with a Polymer Model

open access: yesFrontiers in Physics, 2013
Sister chromatid cohesion denotes the phenomenon that sister chromatids are initially attached to each other in mitosis to guarantee the error-free distribution into the daughter cells.
Yang eZhang   +3 more
doaj   +1 more source

Regulation of Sister-Chromatid Cohesion [PDF]

open access: yes, 2020
Orderly execution of two critical events during the cell cycle--DNA replication and chromosome segregation--ensures the stable transmission of genetic materials.
Zheng, Ge
core   +1 more source

LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion.

open access: yesPLoS Biology, 2012
Successful execution of the meiotic program depends on the timely establishment and removal of sister chromatid cohesion. LAB-1 has been proposed to act in the latter by preventing the premature removal of the meiosis-specific cohesin REC-8 at metaphase ...
Yonatan B Tzur   +7 more
doaj   +1 more source

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