Results 41 to 50 of about 11,947 (194)
Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.
PLoS Genetics, 2018 The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B-Mau2 protein complex
Ziva Misulovin +3 more
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Function and mechanism of cohesin REC8 during meiosis
浙江大学学报. 农业与生命科学版, 2023 Cohesin is a functionally and evolutionarily conserved multi-subunit protein complex that is required for sister chromatid cohesion and chromatin loop structure in both mitosis and meiosis. The meiotic cell-cycle consisting of one DNA replication and two
DAI Jingling, YU Chao
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Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation [PDF]
, 2015 During mitosis, Bub1 kinase phosphorylates histone H2A-T120 to promote centromere sister chromatid cohesion through recruitment of shugoshin (Sgo) proteins. The regulation and dynamics of H2A-T120 phosphorylation are poorly understood. Using quantitative
Lajeunesse, Audrey +6 more
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In Favor of Establishment: Regulation of Chromatid Cohesion in Plants
Frontiers in Plant Science, 2017 In eukaryotic organisms, the correct regulation of sister chromatid cohesion, whereby sister chromatids are paired and held together, is essential for accurate segregation of the sister chromatids and homologous chromosomes into daughter cells during ...
Pablo Bolaños-Villegas +4 more
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The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. [PDF]
PLoS Genetics, 2010 The DNA replication process represents a source of DNA stress that causes potentially spontaneous genome damage. This effect might be strengthened by mutations in crucial replication factors, requiring the activation of DNA damage checkpoints to enable ...
Naoki Takahashi +9 more
doaj +1 more source
Sister Chromatid Cohesion Remodeling and Meiotic Recombination [PDF]
Cell Cycle, 2006 Proper control of cohesion along the chromosome arms is essential for segregation of homologous chromosomes in meiosis. In a recent study we reported that Tid1p, a protein previously implicated in recombination, is required for resolution of Mcd1p-dependent cohesion in meiosis. Here we demonstrate that Pds5p and Dmc1p promote this cohesion.
Anna V, Kateneva, Michael E, Dresser
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Folding of cohesin’s coiled coil is important for Scc2/4-induced association with chromosomes
eLife, 2021 Cohesin’s association with and translocation along chromosomal DNAs depend on an ATP hydrolysis cycle driving the association and subsequent release of DNA. This involves DNA being ‘clamped’ by Scc2 and ATP-dependent engagement of cohesin’s Smc1 and Smc3
Naomi J Petela +13 more
doaj +1 more source
Sequential loading of cohesin subunits during the first meiotic prophase of grasshoppers.
PLoS Genetics, 2007 The cohesin complexes play a key role in chromosome segregation during both mitosis and meiosis. They establish sister chromatid cohesion between duplicating DNA molecules during S-phase, but they also have an important role during postreplicative double-
Ana M Valdeolmillos +10 more
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Sororin actively maintains sister chromatid cohesion. [PDF]
EMBO J, 2016 Abstract Cohesion between sister chromatids is established during DNA replication but needs to be maintained to enable proper chromosome–spindle attachments in mitosis or meiosis. Cohesion is mediated by cohesin, but also depends on cohesin acetylation and sororin. Sororin contributes to cohesion by stabilizing cohesin on DNA. Sororin
Ladurner R +8 more
europepmc +5 more sources
Sister Chromatid Cohesion and Aneuploidy [PDF]
, 2012 In all living organisms, cells arise from the division of a pre-existing cell and inherit one copy of the genome identical to that of the mother cell. Any defect in chromosome segregation can lead to aneuploidy via chromosome gain or loss, and consequently to genetic instability, thereby paving the way for malignant growth and cancer.
Watrin, Erwan, Prigent, Claude
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