Results 51 to 60 of about 947,032 (193)
Sister Chromatid Cohesion Remodeling and Meiotic Recombination [PDF]
Cell Cycle, 2006 Proper control of cohesion along the chromosome arms is essential for segregation of homologous chromosomes in meiosis. In a recent study we reported that Tid1p, a protein previously implicated in recombination, is required for resolution of Mcd1p-dependent cohesion in meiosis. Here we demonstrate that Pds5p and Dmc1p promote this cohesion.
Anna V, Kateneva, Michael E, Dresser
openaire +2 more sources
Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function
Cell Reports, 2016 Sister chromatid cohesion is a fundamental prerequisite to faithful genome segregation. Cohesion is precisely regulated by accessory factors that modulate the stability with which the cohesin complex embraces chromosomes.
Kyle W. Muir +5 more
doaj +1 more source
Nature Communications, 2018 Sustained spindle tension applied to sister centromeres during mitosis leads to loss of sister chromatid cohesion which is known as cohesion fatigue.
Grégory Eot-Houllier +5 more
doaj +1 more source
PHB2 Protects Sister-Chromatid Cohesion in Mitosis [PDF]
Current Biology, 2007 Cohesion between sister chromatids is essential for proper chromosome segregation in mitosis. In vertebrate mitotic cells, most cohesin is removed from the chromosome arms [1-4], but centromeric cohesin is protected by shugoshin until the onset of anaphase [5].
Takata, Hideaki +9 more
openaire +2 more sources
PLoS ONE, 2011 The cohesin complex is required for the cohesion of sister chromatids and for correct segregation during mitosis and meiosis. Crossover recombination, together with cohesion, is essential for the disjunction of homologous chromosomes during the first ...
Antoine Baudrimont +8 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Homologous recombination, sister chromatid cohesion, and chromosome condensation in mammalian meiosis [PDF]
, 2002 In the life cycle of sexually reproducing eukaryotes, haploid and diploid generations of cells alternate. Two types of cell division occur in such a life cycle: mitosis and meiosis. They are compared in chapter 1 .
Eijpe, M.
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Cohesin: Functions beyond sister chromatid cohesion [PDF]
FEBS Letters, 2013 Faithful segregation of chromosomes during mitosis and meiosis is the cornerstone process of life. Cohesin, a multi‐protein complex conserved from yeast to human, plays a crucial role in this process by keeping the sister chromatids together from S‐phase to anaphase onset during mitosis and meiosis.
Mehta, Gunjan D. +3 more
openaire +2 more sources