Results 51 to 60 of about 10,437 (162)
PHB2 Protects Sister-Chromatid Cohesion in Mitosis [PDF]
Current Biology, 2007 Cohesion between sister chromatids is essential for proper chromosome segregation in mitosis. In vertebrate mitotic cells, most cohesin is removed from the chromosome arms [1-4], but centromeric cohesin is protected by shugoshin until the onset of anaphase [5].
Takata, Hideaki +9 more
openaire +2 more sources
Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.
PLoS ONE, 2014 High fidelity chromosome segregation during mitosis requires that cells identify the products of DNA replication during S-phase and then maintain that identity until anaphase onset.
Kevin Tong, Robert V Skibbens
doaj +1 more source
Protocol for High-Throughput Analysis of Sister-Chromatids Contacts
STAR Protocols, 2020 Summary: Sister chromatid interactions are a key step to ensure the successful segregation of sister chromatids after replication. Our knowledge about this phenomenon is mostly based on microscopy approaches, which have some constraints such as ...
Elena Espinosa +2 more
doaj +1 more source
Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function
Cell Reports, 2016 Sister chromatid cohesion is a fundamental prerequisite to faithful genome segregation. Cohesion is precisely regulated by accessory factors that modulate the stability with which the cohesin complex embraces chromosomes.
Kyle W. Muir +5 more
doaj +1 more source
Modifying sister chromatid cohesion for meiosis [PDF]
Journal of Cell Science, 2004 Meiosis produces haploid gametes from diploid cells in two stages that in many ways resemble mitosis. However, the regulatory mechanisms governing kinetochore orientation and cohesion at the first meiotic division are different from those at mitosis: sister kinetochores are pulled forwards from the same spindle pole at metaphase, and centromeric ...
openaire +2 more sources
Nature Communications, 2018 Sustained spindle tension applied to sister centromeres during mitosis leads to loss of sister chromatid cohesion which is known as cohesion fatigue.
Grégory Eot-Houllier +5 more
doaj +1 more source
Sister Chromatid Cohesion and Aneuploidy [PDF]
, 2012 In all living organisms, cells arise from the division of a pre-existing cell and inherit one copy of the genome identical to that of the mother cell. Any defect in chromosome segregation can lead to aneuploidy via chromosome gain or loss, and consequently to genetic instability, thereby paving the way for malignant growth and cancer.
Watrin, Erwan, Prigent, Claude
openaire +2 more sources
PLoS ONE, 2011 The cohesin complex is required for the cohesion of sister chromatids and for correct segregation during mitosis and meiosis. Crossover recombination, together with cohesion, is essential for the disjunction of homologous chromosomes during the first ...
Antoine Baudrimont +8 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The cohesion protein SOLO associates with SMC1 and is required for synapsis, recombination, homolog bias and cohesion and pairing of centromeres in Drosophila Meiosis. [PDF]
PLoS Genetics, 2013 Cohesion between sister chromatids is mediated by cohesin and is essential for proper meiotic segregation of both sister chromatids and homologs. solo encodes a Drosophila meiosis-specific cohesion protein with no apparent sequence homology to cohesins ...
Rihui Yan, Bruce D McKee
doaj +1 more source