Results 51 to 60 of about 921,868 (189)
Modifying sister chromatid cohesion for meiosis [PDF]
Journal of Cell Science, 2004 Meiosis produces haploid gametes from diploid cells in two stages that in many ways resemble mitosis. However, the regulatory mechanisms governing kinetochore orientation and cohesion at the first meiotic division are different from those at mitosis: sister kinetochores are pulled forwards from the same spindle pole at metaphase, and centromeric ...
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A Live-Cell Imaging Approach for Measuring DNA Replication Rates
Cell Reports, 2018 Summary: We describe a simple and direct approach to measure the progression of single DNA replication forks in living cells by monitoring two fluorescently labeled loci downstream of an origin of replication.
Daniel Dovrat +5 more
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The Making and Breaking of Sister Chromatid Cohesion [PDF]
Cell, 2001 The picture that emerges from recent studies is that of an intricate regulatory network, the purpose of which is to ensure that sister chromatids go their separate ways during anaphase. The more we know about the process, the more challenging our next questions become.
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Sister Chromatid Cohesion and Aneuploidy [PDF]
, 2012 In all living organisms, cells arise from the division of a pre-existing cell and inherit one copy of the genome identical to that of the mother cell. Any defect in chromosome segregation can lead to aneuploidy via chromosome gain or loss, and consequently to genetic instability, thereby paving the way for malignant growth and cancer.
Watrin, Erwan, Prigent, Claude
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Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.
PLoS ONE, 2014 High fidelity chromosome segregation during mitosis requires that cells identify the products of DNA replication during S-phase and then maintain that identity until anaphase onset.
Kevin Tong, Robert V Skibbens
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Protocol for High-Throughput Analysis of Sister-Chromatids Contacts
STAR Protocols, 2020 Summary: Sister chromatid interactions are a key step to ensure the successful segregation of sister chromatids after replication. Our knowledge about this phenomenon is mostly based on microscopy approaches, which have some constraints such as ...
Elena Espinosa +2 more
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Sister Chromatid Cohesion Remodeling and Meiotic Recombination [PDF]
Cell Cycle, 2006 Proper control of cohesion along the chromosome arms is essential for segregation of homologous chromosomes in meiosis. In a recent study we reported that Tid1p, a protein previously implicated in recombination, is required for resolution of Mcd1p-dependent cohesion in meiosis. Here we demonstrate that Pds5p and Dmc1p promote this cohesion.
Anna V, Kateneva, Michael E, Dresser
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Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function
Cell Reports, 2016 Sister chromatid cohesion is a fundamental prerequisite to faithful genome segregation. Cohesion is precisely regulated by accessory factors that modulate the stability with which the cohesin complex embraces chromosomes.
Kyle W. Muir +5 more
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Nature Communications, 2018 Sustained spindle tension applied to sister centromeres during mitosis leads to loss of sister chromatid cohesion which is known as cohesion fatigue.
Grégory Eot-Houllier +5 more
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PLoS ONE, 2011 The cohesin complex is required for the cohesion of sister chromatids and for correct segregation during mitosis and meiosis. Crossover recombination, together with cohesion, is essential for the disjunction of homologous chromosomes during the first ...
Antoine Baudrimont +8 more
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