miR-338-3p targets WAPL to suppress proliferation and invasion in cervical cancer cells: experimental insights [PDF]
World Journal of Surgical OncologyObjective This study aimed to elucidate the role of miR-338-3p in cervical cancer, focusing on its regulatory effect on the WAPL (wings apart-like homolog) gene and the consequent influence on the behavior of cervical carcinoma cells.
Ruoyu Wang, Wenkang Liu
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Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromatin [PDF]
EMBO JournalSister chromatid cohesion is mediated by the cohesin complex. In mitotic prophase cohesin is removed from chromosome arms in a Wapl- and phosphorylation-dependent manner. Sgo1-PP2A protects pericentromeric cohesion by dephosphorylation of cohesin and its
Susanne Hellmuth, Olaf Stemmann
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Sororin locks the DNA-exit gate of cohesin to preserve sister-chromatid cohesion [PDF]
Nature CommunicationsThe cohesin complex mediates sister-chromatid cohesion by topologically entrapping DNA within an SMC1-SMC3-RAD21 ring, yet how Sororin preserves cohesion beyond its known role of antagonizing Pds5 binding to the release factor Wapl has remained unclear ...
Qinfu Chen +7 more
doaj +2 more sources
Crosstalk between cohesins and axis proteins determines meiotic chromosome architecture in Sordaria macrospora. [PDF]
PLoS GeneticsFaithful chromosome segregation during meiosis requires the coordinated action of cohesin complexes and chromosome axis proteins. How these factors interact and communicate along chromosome axes, especially during meiotic prophase I, remains however ...
Kenza Yefsah +6 more
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A chromatin-remodeling-independent role for ATRX in protecting centromeric cohesion [PDF]
The EMBO JournalSister-chromatid cohesion mediated by the cohesin complex is critical for accurate chromosome segregation during mitosis. A key aspect of this process is the protection of cohesin at mitotic centromeres to resist spindle pulling-forces until anaphase ...
Lei Zhao +4 more
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Cell Reports, 2016 Mammalian NIMA-like kinase-1 (NEK1) is a dual-specificity kinase highly expressed in mouse germ cells during prophase I of meiosis. Loss of NEK1 induces retention of cohesin on chromosomes at meiotic prophase I.
MIGUEL A Brieno-Enriquez +2 more
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What AlphaFold tells us about cohesin’s retention on and release from chromosomes [PDF]
eLife, 2023 Cohesin is a trimeric complex containing a pair of SMC proteins (Smc1 and Smc3) whose ATPase domains at the end of long coiled coils (CC) are interconnected by Scc1.
Kim A Nasmyth +3 more
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CTCF couples long-range loop extrusion and diffusion to mediate a diverse Igκ repertoire [PDF]
Nature CommunicationsDynamic genome folding is important for V(D)J recombination at the immunoglobulin kappa (Igκ) locus, which recombines Jκ and Vκ gene segments across a 3.2 Mb region in both deletional and inversional orientations.
Emma L. Bush +10 more
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The DNA loop release factor WAPL suppresses Epstein-Barr virus latent membrane protein expression to maintain the highly restricted latency I program. [PDF]
PLoS PathogensEpstein-Barr virus (EBV) uses latency programs to colonize the memory B-cell reservoir, and each program is associated with human malignancies. However, knowledge remains incomplete of epigenetic mechanisms that maintain the highly restricted latency I ...
Laura A Murray-Nerger +7 more
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HTGTS‐TCR‐Seq for Profiling of Mouse and Human T‐Cell Receptor α and β Gene Rearrangements and Diversity [PDF]
Advanced ScienceDeveloping αβ T lymphocytes generate T‐cell receptor (TCR) diversity through V(D)J recombination, which assembles Tcra and Tcrb genes from germline variable (V), diversity (D), and joining (J) segments.
Rui Luo +9 more
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