miR-338-3p targets WAPL to suppress proliferation and invasion in cervical cancer cells: experimental insights [PDF]
World Journal of Surgical OncologyObjective This study aimed to elucidate the role of miR-338-3p in cervical cancer, focusing on its regulatory effect on the WAPL (wings apart-like homolog) gene and the consequent influence on the behavior of cervical carcinoma cells.
Wenkang Liu
exaly +3 more sources
Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromatin [PDF]
EMBO JournalSister chromatid cohesion is mediated by the cohesin complex. In mitotic prophase cohesin is removed from chromosome arms in a Wapl- and phosphorylation-dependent manner. Sgo1-PP2A protects pericentromeric cohesion by dephosphorylation of cohesin and its
Olaf Stemmann, Susanne Hellmuth
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Cell ReportsSummary: Analysis of meiotic prophase in Sordaria macrospora shows that the cohesin-release factor Wapl is a multi-stage modulator of whole-chromosomal dynamics.
Denise Zickler +2 more
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Alterations in chromatin organization promote totipotent-like features in a DPPA2/DUX-dependent manner [PDF]
The EMBO Journal2-cell like cells (2CLC) are a transiently cycling population of cells with totipotent-associated features. Although CTCF depletion induces 2CLC conversion in mouse ESC, whether this reprogramming is a consequence of disrupted higher-order chromatin ...
Grace I Carey +18 more
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Context-dependent regulation of IgH V(D)J recombination by cohesin-STAG1 and cohesin-STAG2 [PDF]
Nature CommunicationsCohesin-mediated loop extrusion is central to IgH V(D)J recombination in early developing B cells, driving D-to-JH rearrangements and VH-to-DJH rearrangements, with the latter step regulated by the cohesin release factor WAPL.
Fujung Chang +7 more
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Sororin locks the DNA-exit gate of cohesin to preserve sister-chromatid cohesion [PDF]
Nature CommunicationsThe cohesin complex mediates sister-chromatid cohesion by topologically entrapping DNA within an SMC1-SMC3-RAD21 ring, yet how Sororin preserves cohesion beyond its known role of antagonizing Pds5 binding to the release factor Wapl has remained unclear ...
Qinfu Chen +7 more
doaj +2 more sources
Crosstalk between cohesins and axis proteins determines meiotic chromosome architecture in Sordaria macrospora. [PDF]
PLoS GeneticsFaithful chromosome segregation during meiosis requires the coordinated action of cohesin complexes and chromosome axis proteins. How these factors interact and communicate along chromosome axes, especially during meiotic prophase I, remains however ...
Kenza Yefsah +6 more
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Cell Reports, 2016 Mammalian NIMA-like kinase-1 (NEK1) is a dual-specificity kinase highly expressed in mouse germ cells during prophase I of meiosis. Loss of NEK1 induces retention of cohesin on chromosomes at meiotic prophase I.
Paula Cohen +2 more
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A chromatin-remodeling-independent role for ATRX in protecting centromeric cohesion [PDF]
The EMBO JournalSister-chromatid cohesion mediated by the cohesin complex is critical for accurate chromosome segregation during mitosis. A key aspect of this process is the protection of cohesin at mitotic centromeres to resist spindle pulling-forces until anaphase ...
Lei Zhao +4 more
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CTCF couples long-range loop extrusion and diffusion to mediate a diverse Igκ repertoire [PDF]
Nature CommunicationsDynamic genome folding is important for V(D)J recombination at the immunoglobulin kappa (Igκ) locus, which recombines Jκ and Vκ gene segments across a 3.2 Mb region in both deletional and inversional orientations.
Emma L. Bush +10 more
doaj +2 more sources