Results 11 to 20 of about 1,291 (151)

HTGTS‐TCR‐Seq for Profiling of Mouse and Human T‐Cell Receptor α and β Gene Rearrangements and Diversity [PDF]

Advanced Science
Developing αβ T lymphocytes generate T‐cell receptor (TCR) diversity through V(D)J recombination, which assembles Tcra and Tcrb genes from germline variable (V), diversity (D), and joining (J) segments.
Rui Luo, Yawei Song, Meichen Wang, Longhao Zou, Fangtai Jiao, Tiange Yang, Guangchuan Wang, Zhuoyi Liang, Wei Wu, Hai‐Qiang Dai   +9 more
doaj   +3 more sources

Sororin is an evolutionary conserved antagonist of WAPL [PDF]

Nature Communications
Cohesin mediates sister chromatid cohesion to enable chromosome segregation and DNA damage repair. To perform these functions, cohesin needs to be protected from WAPL, which otherwise releases cohesin from DNA.
Ignacio Prusén Mota, Marta Galova, Alexander Schleiffer, Tan-Trung Nguyen, Ines Kovacikova, Carolina Farias Saad, Gabriele Litos, Tomoko Nishiyama, Juraj Gregan, Jan-Michael Peters, Peter Schlögelhofer   +10 more
doaj   +6 more sources

Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex [PDF]

Proceedings of the National Academy of Sciences of the United States of America
The ring-shaped Cohesin complex, consisting of core subunits Smc1, Smc3, Scc1, and SA2 (or its paralog SA1), topologically entraps two duplicated sister DNA molecules to establish sister chromatid cohesion in S-phase. It remains largely elusive how the Cohesin release factor Wapl binds the Cohesin complex, thereby inducing Cohesin disassociation from ...
Fangwei Wang, , Xiaojing He
exaly   +4 more sources

Chromosomal localization of cohesin is differentially regulated by WIZ, WAPL, and G9a

BMC Genomics, 2022
Background The cohesin complex is essential for proper chromosome structure and gene expression. Defects in cohesin subunits and regulators cause changes in cohesin complex dynamics and thereby alter three-dimensional genome organization.
Megan Justice, Audra F. Bryan, Juanita C. Limas, Jeanette Gowen Cook, Jill M. Dowen   +4 more
doaj   +3 more sources

Arabidopsis thaliana WAPL is essential for the prophase removal of cohesin during meiosis.

PLoS Genetics, 2014
Sister chromatid cohesion, which is mediated by the cohesin complex, is essential for the proper segregation of chromosomes in mitosis and meiosis.
Kuntal De, Lauren Sterle, Laura Krueger, Xiaohui Yang, Christopher A Makaroff   +4 more
doaj   +3 more sources

S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion [PDF]

The EMBO Journal
Sororin is essential for establishing sister chromatid cohesion concurrently with DNA replication in metazoans. Although acetylation of the cohesin subunit SMC3 by ESCO1/2 is necessary for Sororin recruitment, it is by itself not sufficient.
Meiqian Jiang, Jiaxin Zhang, Jiankun He, Yu Miao, Linhui Wang, Haitao Zhong, Yingying Gong, Zhen Li, Li-Lin Du, Xingzhi Xu, Chunlai Chen, Alibek Ydyrys, Yisui Xia, Qinhong Cao, Huiqiang Lou, Wenya Hou   +15 more
doaj   +2 more sources

Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.

PLoS Genetics, 2018
The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B-Mau2 protein complex
Ziva Misulovin, Michelle Pherson, Maria Gause, Dale Dorsett   +3 more
doaj   +4 more sources

A non-canonical role of the inner kinetochore in regulating sister-chromatid cohesion at centromeres [PDF]

The EMBO Journal
The 16-subunit Constitutive Centromere-associated Network (CCAN)-based inner kinetochore is well-known for connecting centromeric chromatin to the spindle-binding outer kinetochore.
Lu Yan, Xueying Yuan, Mingjie Liu, Qinfu Chen, Miao Zhang, Junfen Xu, Ling-Hui Zeng, Long Zhang, Jun Huang, Weiguo Lu, Xiaojing He, Haiyan Yan, Fangwei Wang   +12 more
doaj   +2 more sources

Cohesin positions the epigenetic reader Phf2 within the genome [PDF]

The EMBO Journal
Genomic DNA is assembled into chromatin by histones, and extruded into loops by cohesin. These mechanisms control important genomic functions, but whether histones and cohesin cooperate in genome regulation is poorly understood.
Wen Tang, Lorenzo Costantino, Roman Stocsits, Gordana Wutz, Rene Ladurner, Otto Hudecz, Karl Mechtler, Jan-Michael Peters   +7 more
doaj   +2 more sources

Cooperative Roles of Pds5a and Pds5b Constrain Long-Range Chromatin Interactions in Vertebrate Embryos. [PDF]

Dev Growth Differ
ABSTRACT Three‐dimensional (3D) genome organization is dynamically restructured during early vertebrate development, yet how chromatin domains are established remains poorly understood. In particular, the contribution of individual cohesin regulators to this process during embryogenesis is unclear.
Ikeda S, Takeda H, Nakamura R.
europepmc   +2 more sources