Arabidopsis thaliana WAPL is essential for the prophase removal of cohesin during meiosis.
PLoS Genetics, 2014 Sister chromatid cohesion, which is mediated by the cohesin complex, is essential for the proper segregation of chromosomes in mitosis and meiosis.
Kuntal De +4 more
doaj +4 more sources
HTGTS‐TCR‐Seq for Profiling of Mouse and Human T‐Cell Receptor α and β Gene Rearrangements and Diversity [PDF]
Advanced ScienceDeveloping αβ T lymphocytes generate T‐cell receptor (TCR) diversity through V(D)J recombination, which assembles Tcra and Tcrb genes from germline variable (V), diversity (D), and joining (J) segments.
Rui Luo +9 more
doaj +3 more sources
Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function. [PDF]
PLoS Genetics, 2018 The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B-Mau2 protein complex
Ziva Misulovin +3 more
doaj +5 more sources
A Wapl a Day Keeps the Sisters Apart: Wapl and Cohesin Dynamics [PDF]
Developmental Cell, 2006 Sister chromatids are held together by the cohesin complex from the time they are made until cell division. In recent articles published in Cell and Current Biology, the characterization of Wapl, a newly identified cohesin-interacting protein, suggests ...
Susannah Rankin, Rankin, Susannah
core +4 more sources
Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes [PDF]
eLife, 2016 Wapl induces cohesin dissociation from DNA throughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure.
Oliver Crawley +7 more
doaj +2 more sources
Chromosome Biology: Wapl Spreads Its Wings [PDF]
Current Biology, 2013 SummaryChromosome segregation requires the removal of cohesion and catenation between sister chromosomes, two physical linkages established during DNA replication.
Yu, Hongtao
core +4 more sources
Condensin I protects meiotic cohesin from WAPL-1 mediated removal. [PDF]
PLoS Genetics, 2018 Condensin complexes are key determinants of higher-order chromatin structure and are required for mitotic and meiotic chromosome compaction and segregation.
Margarita R Hernandez +5 more
doaj +2 more sources
Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaThe ring-shaped Cohesin complex, consisting of core subunits Smc1, Smc3, Scc1, and SA2 (or its paralog SA1), topologically entraps two duplicated sister DNA molecules to establish sister chromatid cohesion in S-phase. It remains largely elusive how the Cohesin release factor Wapl binds the Cohesin complex, thereby inducing Cohesin disassociation from ...
Fangwei Wang, Xiaojing He
exaly +4 more sources
Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression.
PLoS Genetics, 2022 The relationship between cohesin-mediated chromatin looping and gene expression remains unclear. NIPBL and WAPL are two opposing regulators of cohesin activity; depletion of either is associated with changes in both chromatin folding and transcription ...
Jennifer M Luppino +10 more
doaj +2 more sources
Budding Yeast Wapl Controls Sister Chromatid Cohesion Maintenance and Chromosome Condensation [PDF]
Current Biology, 2013 SummaryThe establishment of stable sister chromatid cohesion during DNA replication requires acetylation of the chromosomal cohesin complex by the replication fork-associated acetyltransferase Eco1 [1–8].
Borges, Vanessa +4 more
core +4 more sources