Sororin is an evolutionary conserved antagonist of WAPL [PDF]
Nature CommunicationsCohesin mediates sister chromatid cohesion to enable chromosome segregation and DNA damage repair. To perform these functions, cohesin needs to be protected from WAPL, which otherwise releases cohesin from DNA.
Ignacio Prusén Mota +10 more
doaj +6 more sources
Arabidopsis thaliana WAPL is essential for the prophase removal of cohesin during meiosis.
PLoS Genetics, 2014 Sister chromatid cohesion, which is mediated by the cohesin complex, is essential for the proper segregation of chromosomes in mitosis and meiosis.
Kuntal De +4 more
doaj +4 more sources
Chromosomal localization of cohesin is differentially regulated by WIZ, WAPL, and G9a
BMC Genomics, 2022 Background The cohesin complex is essential for proper chromosome structure and gene expression. Defects in cohesin subunits and regulators cause changes in cohesin complex dynamics and thereby alter three-dimensional genome organization.
Megan Justice +4 more
doaj +4 more sources
A Wapl a Day Keeps the Sisters Apart: Wapl and Cohesin Dynamics [PDF]
Developmental Cell, 2006 Sister chromatids are held together by the cohesin complex from the time they are made until cell division. In recent articles published in Cell and Current Biology, the characterization of Wapl, a newly identified cohesin-interacting protein, suggests ...
Susannah Rankin, Rankin, Susannah
core +3 more sources
Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes [PDF]
eLife, 2016 Wapl induces cohesin dissociation from DNA throughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure.
Oliver Crawley +7 more
doaj +2 more sources
Chromosome Biology: Wapl Spreads Its Wings [PDF]
Current Biology, 2013 SummaryChromosome segregation requires the removal of cohesion and catenation between sister chromosomes, two physical linkages established during DNA replication.
Yu, Hongtao
core +3 more sources
Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaThe ring-shaped Cohesin complex, consisting of core subunits Smc1, Smc3, Scc1, and SA2 (or its paralog SA1), topologically entraps two duplicated sister DNA molecules to establish sister chromatid cohesion in S-phase. It remains largely elusive how the Cohesin release factor Wapl binds the Cohesin complex, thereby inducing Cohesin disassociation from ...
Xueying Yuan, Lu Yan, Shukai Zhu
exaly +4 more sources
Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers. [PDF]
Nucleic Acids ResInterphase chromosomes are mainly shaped by loop extrusion and compartmentalisation mechanisms. However, their temporal component and cause-effect relationships remain largely unknown.
Liu NQ +6 more
europepmc +5 more sources
Condensin I protects meiotic cohesin from WAPL-1 mediated removal.
PLoS Genetics, 2018 Condensin complexes are key determinants of higher-order chromatin structure and are required for mitotic and meiotic chromosome compaction and segregation.
Margarita R Hernandez +5 more
doaj +2 more sources
Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression.
PLoS Genetics, 2022 The relationship between cohesin-mediated chromatin looping and gene expression remains unclear. NIPBL and WAPL are two opposing regulators of cohesin activity; depletion of either is associated with changes in both chromatin folding and transcription ...
Jennifer M Luppino +10 more
doaj +2 more sources