Results 31 to 40 of about 1,291 (151)
Chromosome Biology: Wapl Spreads Its Wings [PDF]
Current Biology, 2013 Chromosome segregation requires the removal of cohesion and catenation between sister chromosomes, two physical linkages established during DNA replication. Two new studies reveal that, among other functions, the wings apart-like protein (Wapl) coordinates cohesin removal with decatenation of sister chromosomes during mitosis in mammalian cells.
openaire +2 more sources
Condensin I protects meiotic cohesin from WAPL-1 mediated removal.
PLoS Genetics, 2018 Condensin complexes are key determinants of higher-order chromatin structure and are required for mitotic and meiotic chromosome compaction and segregation.
Margarita R Hernandez +5 more
doaj +1 more source
ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL
eLife, 2020 Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL.
Gordana Wutz +19 more
doaj +1 more source
Correction of water vapor absorption for aerosol remote sensing with ceilometers [PDF]
Atmospheric Measurement Techniques, 2015 In recent years attention was increasingly paid to backscatter profiles of ceilometers as a new source of aerosol information. Several case studies have shown that – although originally intended for cloud detection only – ceilometers can provide the ...
M. Wiegner, J. Gasteiger
doaj +1 more source
Frontiers in Plant Science, 2021 Cohesin is a multi-unit protein complex from the structural maintenance of chromosomes (SMC) family, required for holding sister chromatids together during mitosis and meiosis.
Pablo Bolaños-Villegas +1 more
doaj +1 more source
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface
eLife, 2021 Dramatic change in chromosomal DNA morphology between interphase and mitosis is a defining features of the eukaryotic cell cycle. Two types of enzymes, namely cohesin and condensin confer the topology of chromosomal DNA by extruding DNA loops.
Martin Houlard +9 more
doaj +1 more source
eLife, 2022 Cohesin organizes the genome by forming intra-chromosomal loops and inter-sister chromatid linkages. During gamete formation by meiosis, chromosomes are reshaped to support crossover recombination and two consecutive rounds of chromosome segregation ...
Rachael E Barton +3 more
doaj +1 more source
SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis
Nature Communications, 2019 During cell division, Soronin antagonises WAPL to prevent premature loss of sister chromatid cohesion. Here the authors show that, despite a lack of sequence similarity, the Arabidopsis SWI1 protein functions as a novel Soronin-like WAPL antagonist ...
Chao Yang +6 more
doaj +1 more source
Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1
eLife, 2019 Cohesin’s association with chromosomes is determined by loading dependent on the Scc2/4 complex and release due to Wapl. We show here that Scc2 also actively maintains cohesin on chromosomes during G1 in S. cerevisiae cells. It does so by blocking a Wapl-
Madhusudhan Srinivasan +8 more
doaj +1 more source
A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis
FEBS Letters, 2004 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) is an endocrine disruptor that produces a variety of toxic effects. We have isolated a mouse homolog of the hWAPL gene, termed mouse WAPL (mWAPL), as a target of TCDD by cDNA representational difference analysis from mouse embryonic stem cells.
Kuroda, Masahiko +8 more
openaire +2 more sources