Results 31 to 40 of about 1,661 (174)
Reproductive Biology and Endocrinology, 2021 Background In mitotic cells, WAPL acts as a cohesin release factor to remove cohesin complexes from chromosome arms during prophase to allow the accurate chromosome segregation in anaphase.
Changyin Zhou +3 more
doaj +1 more source
Rearrangement of T Cell genome architecture regulates GVHD
iScience, 2022 Summary: WAPL, cohesin’s DNA release factor, regulates three-dimensional (3D) chromatin architecture. The 3D chromatin structure and its relevance to mature T cell functions is not well understood.
Yaping Sun +10 more
doaj +1 more source
Structure of the human cohesin inhibitor Wapl [PDF]
Proceedings of the National Academy of Sciences, 2013 Cohesin, along with positive regulators, establishes sister-chromatid cohesion by forming a ring to circle chromatin. The wings apart-like protein (Wapl) is a key negative regulator of cohesin and forms a complex with precocious dissociation of sisters protein 5 (Pds5) to promote cohesin release from chromatin.
Zhuqing, Ouyang +8 more
openaire +2 more sources
Investigation of the role of Pds5 and Wapl in sister chromatid separation in mammalian cells
, 2013 The key element of sister chromatid cohesion (SCC) is the cohesin complex composed of Smc1, Smc3, Scc1 and Scc3 (SA1 and SA2 in vertebrates). However, additional proteins such as Pds5 and Wapl are also known to regulate SCC. Most of our knowledge of Pds5
Naif Abdulaziz Binjumah (7658981)
core +6 more sources
Cooperative Roles of Pds5a and Pds5b Constrain Long-Range Chromatin Interactions in Vertebrate Embryos. [PDF]
Dev Growth DifferABSTRACT Three‐dimensional (3D) genome organization is dynamically restructured during early vertebrate development, yet how chromatin domains are established remains poorly understood. In particular, the contribution of individual cohesin regulators to this process during embryogenesis is unclear.
Ikeda S, Takeda H, Nakamura R.
europepmc +2 more sources
Biological processes associated with WAPL knockdown.
, 2022 Top 10 GO Biological Processes for WAPL DEGs sorted by adjusted p-value. (DOCX)
Rebecca Yunker (14197613) +10 more
core +1 more source
Where, When, and How? Integrating Spatiotemporal Cues in Cell Division. [PDF]
BioessaysAccurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Cirillo L +3 more
europepmc +2 more sources
Transcription and Three-Dimensional Genome Organization: Cause, Consequence, or Coordination? [PDF]
BioessaysTranscription and 3D genome organization influence each other across spatial scales. Large‐scale architecture provides a relatively stable framework, while transcription and shared architectural factors refine local chromatin loops and domain boundaries. Specific long‐range interactions between regulatory elements and distal anchors can override domain‐
Yang D, Lei EP.
europepmc +2 more sources
NIPBL and WAPL balance cohesin activity to regulate gene expression.
, 2022 (A) The log2(fold change) of genes after NIPBL and WAPL double knockdown versus their significance. DEGs are in light grey (587 up, 455 down) and non-significantly changed genes (adjusted p-value > 0.01) are in dark grey.
Rebecca Yunker (14197613) +10 more
core +1 more source
SORORIN is an evolutionary conserved antagonist of WAPL
, 2022 Abstract Cohesin mediates sister chromatid cohesion to enable chromosome segregation and DNA damage repair. To perform these functions, cohesin needs to be protected from WAPL, which otherwise releases cohesin from DNA. It has been proposed that cohesin is protected from WAPL by SORORIN.
Ignacio Prusen Mota +8 more
openaire +1 more source