Results 51 to 60 of about 1,291 (151)
Developmental Dynamics, Volume 255, Issue 4, Page 403-416, April 2026.Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez +4 more
wiley +1 more source
Epigenetics & Chromatin, 2022 Background The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or STAG2 subunit, and two versions of
Ana Cuadrado +6 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 2, Page 260-281, February 2026.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion [PDF]
Nature Structural & Molecular Biology, 2014 Orderly termination of sister-chromatid cohesion during mitosis is critical for accurate chromosome segregation. During prophase, mitotic kinases phosphorylate cohesin and its protector sororin, triggering Wapl-dependent cohesin release from chromosome arms.
Hara, Kodai +7 more
openaire +2 more sources
Nature Communications, 2019 Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.
V. Pragathi Masamsetti +10 more
doaj +1 more source
Animals, 2023 Canine lymphoma (CL) is one of the most common malignant tumors in dogs. The cause of CL remains unclear. Genetic mutations that have been suggested as possible causes of CL are not fully understood.
Sungryong Kim +5 more
doaj +1 more source
Diploid origins and early genome stabilization in the allotetraploid Arabidopsis suecica
New Phytologist, Volume 249, Issue 1, Page 524-538, January 2026.Summary Polyploidization, followed by genome downsizing, is a recurrent evolutionary cycle that dramatically reshapes genome structure. Newly formed polyploids must quickly adjust their cell division machinery to maintain stable chromosome inheritance, while long‐term stabilization involves rediploidization, returning the genome to a diploid‐like state.
Robin Burns +6 more
wiley +1 more source
Journal of Phycology, Volume 61, Issue 6, Page 1681-1698, December 2025.Abstract As climate change is having increasingly visible impacts on coastal regions, it is urgent to better understand its effects on the state of ecosystems and the services they provide. To assess the direction and magnitude of change in the high‐use waters of the Sept‐Îles region in the Gulf of St‐Lawrence, we sampled 35 sites along the coast and ...
Emilie Arseneault +1 more
wiley +1 more source
Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl [PDF]
Genes & Development, 2012 DNA double-strand breaks (DSBs) fuel cancer-driving chromosome translocations. Two related structural maintenance of chromosomes (Smc) complexes, cohesin and Smc5/6, promote DSB repair through sister chromatid homologous recombination (SCR). Here we show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1.
Nan, Wu +6 more
openaire +2 more sources
Advanced Science, Volume 12, Issue 38, October 13, 2025.As an m6A reader, hnRNPA2B1 predominantly regulates specific transcripts (e.g., Ep400, Rrs1) that are essential for chromosome organization and remodeling in an m6A‐dependent manner. Furthermore, it is demonstrated to interact with factors involved in mRNA processing and translation. This dual functionality is pivotal for ensuring the proper occurrence
Lisha Yin +11 more
wiley +1 more source