Results 71 to 80 of about 1,554 (181)

m6A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post‐Transcriptional Control

Advanced Science, Volume 12, Issue 38, October 13, 2025.
As an m6A reader, hnRNPA2B1 predominantly regulates specific transcripts (e.g., Ep400, Rrs1) that are essential for chromosome organization and remodeling in an m6A‐dependent manner. Furthermore, it is demonstrated to interact with factors involved in mRNA processing and translation. This dual functionality is pivotal for ensuring the proper occurrence
Lisha Yin, Yuting Zhang, Bingqian Zhang, Jin Zhang, Mengneng Xiong, Nan Jiang, Jinxin Xiao, Huihui Gao, Wenjing Xiong, Xiaoli Wang, Fengli Wang, Shuiqiao Yuan   +11 more
wiley   +1 more source

Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release

, 2021
The alternative PCNA loader containing CTF18-DCC1-CTF8 facilitates sister chromatid cohesion (SCC) by poorly defined mechanisms. Here we find that in DT40 cells, CTF18 acts complementarily with the Warsaw breakage syndrome DDX11 helicase in mediating SCC
Kawasumi, R (via Mendeley Data)
core   +1 more source

Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl [PDF]

Genes & Development, 2012
DNA double-strand breaks (DSBs) fuel cancer-driving chromosome translocations. Two related structural maintenance of chromosomes (Smc) complexes, cohesin and Smc5/6, promote DSB repair through sister chromatid homologous recombination (SCR). Here we show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1.
Nan, Wu, Xiangduo, Kong, Zhejian, Ji, Weihua, Zeng, Patrick Ryan, Potts, Kyoko, Yokomori, Hongtao, Yu   +6 more
openaire   +2 more sources

Early detection of plant community responses to climate warming along mountain roads

Journal of Ecology, Volume 113, Issue 9, Page 2575-2589, September 2025.
Plants are rapidly shifting to higher elevations along mountain roads in Switzerland. These shifts result in a significant community warming of 0.13°C within 10 years. However, because species gained or lost in communities tend to have low cover, this signal is only detectable in unweighted estimates of community‐inferred temperatures—highlighting the ...
Evelin Iseli, Nathan Diaz Zeugin, Camille Brioschi, Jake Alexander, Jonathan Lenoir   +4 more
wiley   +1 more source

EBV Latency Programs: Molecular and Epigenetic Regulation and Its Role in Disease Pathogenesis

Journal of Medical Virology, Volume 97, Issue 7, July 2025.
ABSTRACT Epstein‐Barr virus (EBV) asymptomatically infects over 95% of the global population, and poses a great threat to human health. This review summarizes the complex mechanisms underlying EBV latency programs and their roles in both viral persistence and disease development.
Likang Lyu, Qian Li, Chong Wang
wiley   +1 more source

Migration of Deep Convection Center in Subpolar North Atlantic Around 6 ka Suggested by a Dinocyst Proxy of Mixed Layer Depth

Paleoceanography and Paleoclimatology, Volume 40, Issue 6, June 2025.
Abstract This study explores the relationship between dinoflagellate cyst (dinocyst) assemblages and the mixed layer depth (MLD) using canonical correspondence analyses. Our results suggest that wintertime deepening of MLD, in response to deep convection events, can influence dinocyst assemblages and especially the relative abundance of ...
Xiner Wu, Anne de Vernal, Estelle Allan
wiley   +1 more source

Arabidopsis WAPL protein and gene structures.

, 2014
(A) WAPL proteins from different organisms are shown. Yellow boxes represent the conserved WAPL domain. Black lines in human Wapl represent FGF motifs, which are involved in PDS5 binding. Sizes of the proteins in amino acids are shown to the right.
Laura Krueger (599824), Christopher A. Makaroff (352349), Lauren Sterle (599823), Xiaohui Yang (352345), Kuntal De (599822)   +4 more
core   +1 more source

In Favor of Establishment: Regulation of Chromatid Cohesion in Plants

Frontiers in Plant Science, 2017
In eukaryotic organisms, the correct regulation of sister chromatid cohesion, whereby sister chromatids are paired and held together, is essential for accurate segregation of the sister chromatids and homologous chromosomes into daughter cells during ...
Pablo Bolaños-Villegas, Kuntal De, Mónica Pradillo, Desheng Liu, Christopher A. Makaroff   +4 more
doaj   +1 more source

Quinoline ATP Synthase Inhibitors with Activity Against Multidrug Resistant Acinetobacter baumannii and Pseudomonas aeruginosa

ChemMedChem, Volume 20, Issue 10, May 19, 2025.
Targeting ATP synthase in Gram‐negative pathogens. Presented is the first disclosure of quinoline‐derived antibiotics inhibiting multidrug resistant Acinetobacter baumannii ATP synthase and expansion of the structure activity relationship profile of Pseudomonas aeruginosa ATP synthase inhibitors.
Katie T. Ward, Alexander P. L. Williams, Angelina L. Dennison, Lena Aamir, Darien L. Allen, Britza Chavez‐Arellano, Toni A. Marchlewski, Mars L. Zappia, Amanda L. Wolfe, P. Ryan Steed   +9 more
wiley   +1 more source

NIPBL and WAPL balance cohesin activity to regulate chromatin organization and gene expression.

, 2022
Cohesin normally promotes the compaction and clustering of chromatin into TADs, which we propose act as regulatory hubs. These hubs can either stimulate (Active, blue) or repress (Inactive, Red) expression of nearby genes in a dynamic fashion.
Rebecca Yunker (14197613), Parisha P. Shah (9380961), Eric F. Joyce (7900052), Rajan Jain (422776), Karen Adelman (4540336), Jennifer M. Luppino (14197610), Yemin Lan (330697), Andrew Field (12393694), Son C. Nguyen (1332762), Richard J. Abdill (6719147), Daniel S. Park (14117041)   +10 more
core   +1 more source