Results 71 to 80 of about 1,661 (174)
Epigenetics & Chromatin, 2022 Background The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or STAG2 subunit, and two versions of
Ana Cuadrado +6 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 2, Page 260-281, February 2026.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion [PDF]
Nature Structural & Molecular Biology, 2014 Orderly termination of sister-chromatid cohesion during mitosis is critical for accurate chromosome segregation. During prophase, mitotic kinases phosphorylate cohesin and its protector sororin, triggering Wapl-dependent cohesin release from chromosome arms.
Hara, Kodai +7 more
openaire +2 more sources
Nature Communications, 2019 Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.
V. Pragathi Masamsetti +10 more
doaj +1 more source
Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1 [PDF]
, 2022 It remains unclear why acute depletion of CTCF (CCCTC-binding factor) and cohesin only marginally affects expression of most genes despite substantially perturbing three-dimensional (3D) genome folding at the level of domains and structural loops.
Hansen, Anders S +7 more
core +1 more source
Diploid origins and early genome stabilization in the allotetraploid Arabidopsis suecica
New Phytologist, Volume 249, Issue 1, Page 524-538, January 2026.Summary Polyploidization, followed by genome downsizing, is a recurrent evolutionary cycle that dramatically reshapes genome structure. Newly formed polyploids must quickly adjust their cell division machinery to maintain stable chromosome inheritance, while long‐term stabilization involves rediploidization, returning the genome to a diploid‐like state.
Robin Burns +6 more
wiley +1 more source
Journal of Phycology, Volume 61, Issue 6, Page 1681-1698, December 2025.Abstract As climate change is having increasingly visible impacts on coastal regions, it is urgent to better understand its effects on the state of ecosystems and the services they provide. To assess the direction and magnitude of change in the high‐use waters of the Sept‐Îles region in the Gulf of St‐Lawrence, we sampled 35 sites along the coast and ...
Emilie Arseneault +1 more
wiley +1 more source
Advanced Science, Volume 12, Issue 38, October 13, 2025.As an m6A reader, hnRNPA2B1 predominantly regulates specific transcripts (e.g., Ep400, Rrs1) that are essential for chromosome organization and remodeling in an m6A‐dependent manner. Furthermore, it is demonstrated to interact with factors involved in mRNA processing and translation. This dual functionality is pivotal for ensuring the proper occurrence
Lisha Yin +11 more
wiley +1 more source
Early detection of plant community responses to climate warming along mountain roads
Journal of Ecology, Volume 113, Issue 9, Page 2575-2589, September 2025.Plants are rapidly shifting to higher elevations along mountain roads in Switzerland. These shifts result in a significant community warming of 0.13°C within 10 years. However, because species gained or lost in communities tend to have low cover, this signal is only detectable in unweighted estimates of community‐inferred temperatures—highlighting the ...
Evelin Iseli +4 more
wiley +1 more source
Arabidopsis WAPL protein and gene structures.
, 2014 (A) WAPL proteins from different organisms are shown. Yellow boxes represent the conserved WAPL domain. Black lines in human Wapl represent FGF motifs, which are involved in PDS5 binding. Sizes of the proteins in amino acids are shown to the right.
Laura Krueger (599824) +4 more
core +1 more source