Results 91 to 100 of about 1,661 (174)
ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL. [PDF]
, 2019 Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL.
Roitinger, Elisabeth +19 more
core +2 more sources
NIPBL and WAPL balance cohesin activity to regulate chromatin organization and gene expression.
, 2022 Cohesin normally promotes the compaction and clustering of chromatin into TADs, which we propose act as regulatory hubs. These hubs can either stimulate (Active, blue) or repress (Inactive, Red) expression of nearby genes in a dynamic fashion.
Rebecca Yunker (14197613) +10 more
core +1 more source
Crystal Structure of the Cohesin Gatekeeper Pds5 and in Complex with Kleisin Scc1
Cell Reports, 2016 Sister chromatid cohesion is mediated by cohesin, whose Smc1, Smc3, and kleisin (Scc1) subunits form a ring structure that entraps sister DNAs. The ring is opened either by separase, which cleaves Scc1 during anaphase, or by a releasing activity ...
Byung-Gil Lee +6 more
doaj +1 more source
Cohesin Can Remain Associated with Chromosomes during DNA Replication
Cell Reports, 2017 To ensure disjunction to opposite poles during anaphase, sister chromatids must be held together following DNA replication. This is mediated by cohesin, which is thought to entrap sister DNAs inside a tripartite ring composed of its Smc and kleisin (Scc1)
James D.P. Rhodes +5 more
doaj +1 more source
PLoS Genetics, 2019 Sister chromatid cohesion on chromosome arms is essential for the segregation of homologous chromosomes during meiosis I while it is dispensable for sister chromatid separation during mitosis.
Kiran Challa +5 more
doaj +1 more source
Wapl antagonizes cohesin binding and promotes Polycomb-group silencing inDrosophila
Development, 2012 Wapl protein regulates binding of the cohesin complex to chromosomes during interphase and helps remove cohesin from chromosomes at mitosis. We isolated a dominant mutation in wapl (waplAG) in a screen for mutations that counteract silencing mediated by an engrailed Polycomb-group response element.
Melissa D, Cunningham +6 more
openaire +3 more sources
Frontiers in Plant Science, 2015 Maintenance and precise regulation of sister chromatid cohesion is essential for faithful chromosome segregation during mitosis and meiosis. Cohesin cofactors contribute to cohesin dynamics and interact with cohesin complexes during cell cycle.
Mónica ePradillo +6 more
doaj +1 more source
A non-canonical role of the inner kinetochore in regulating sister-chromatid cohesion at centromeres
The EMBO JournalThe 16-subunit Constitutive Centromere-associated Network (CCAN)-based inner kinetochore is well-known for connecting centromeric chromatin to the spindle-binding outer kinetochore.
Lu Yan +12 more
doaj +1 more source
Condensin I protects cohesin from WAPL-1-mediated removal.
, 2018 (A) Cartoons of meiotic cohesin and condensin complexes. (B) Immunofluorescence analysis of REC-8 and COH-3/4 in early (EP) and late (LP) pachytene nuclei of dpy-28(tm3535) mutant and wild type males treated with empty or wapl-1 RNAi vector.
Györgyi Csankovszki (202404) +5 more
core +1 more source