Results 91 to 100 of about 1,554 (181)
Roles of Wapl in cell cycle progression and chromosome segregation
, 2010 In der mitotischen Zellteilung hängt die Segregation der Chromosomen von der Kohäsion der Schwesterchromatiden ab, die durch den Proteinkomplex Cohesin hergestellt wird. Die Chromosomenkohäsion ermöglicht die bipolare Orientierung der Chromosomen auf der
Tedeschi, Antonio
core
PLoS Genetics, 2019 Sister chromatid cohesion on chromosome arms is essential for the segregation of homologous chromosomes during meiosis I while it is dispensable for sister chromatid separation during mitosis.
Kiran Challa +5 more
doaj +1 more source
Frontiers in Plant Science, 2015 Maintenance and precise regulation of sister chromatid cohesion is essential for faithful chromosome segregation during mitosis and meiosis. Cohesin cofactors contribute to cohesin dynamics and interact with cohesin complexes during cell cycle.
Mónica ePradillo +6 more
doaj +1 more source
Condensin I protects cohesin from WAPL-1-mediated removal.
, 2018 (A) Cartoons of meiotic cohesin and condensin complexes. (B) Immunofluorescence analysis of REC-8 and COH-3/4 in early (EP) and late (LP) pachytene nuclei of dpy-28(tm3535) mutant and wild type males treated with empty or wapl-1 RNAi vector.
Györgyi Csankovszki (202404) +5 more
core +1 more source
ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL.
, 2019 Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL.
Roitinger, Elisabeth +19 more
core +1 more source
Wapl antagonizes cohesin binding and promotes Polycomb-group silencing inDrosophila
Development, 2012 Wapl protein regulates binding of the cohesin complex to chromosomes during interphase and helps remove cohesin from chromosomes at mitosis. We isolated a dominant mutation in wapl (waplAG) in a screen for mutations that counteract silencing mediated by an engrailed Polycomb-group response element.
Melissa D, Cunningham +6 more
openaire +3 more sources
PLoS Genetics, 2019 Sister centromere fusion is a process unique to meiosis that promotes co-orientation of the sister kinetochores, ensuring they attach to microtubules from the same pole during metaphase I.
Lin-Ing Wang, Arunika Das, Kim S McKim
doaj +1 more source
Investigation of the role of Pds5 and Wapl in sister chromatid separation in mammalian cells
, 2013 The key element of sister chromatid cohesion (SCC) is the cohesin complex composed of Smc1, Smc3, Scc1 and Scc3 (SA1 and SA2 in vertebrates). However, additional proteins such as Pds5 and Wapl are also known to regulate SCC. Most of our knowledge of Pds5
Naif Abdulaziz Binjumah (7658981)
core
CTCF, WAPL and PDS5 proteins control the formation of TADs and loops by cohesin
, 2017 Mammalian genomes are organized into compartments, topologically-associating domains (TADs) and loops to facilitate gene regulation and other chromosomal functions. Compartments are formed by nucleosomal interactions, but how TADs and loops are generated
Roman Stocsits +16 more
core +1 more source
PLoS ONE, 2011 For self-renewal, embryonic stem cells (ESCs) require the expression of specific transcription factors accompanied by a particular chromosome organization to maintain a balance between pluripotency and the capacity for rapid differentiation. However, how
Anja Nitzsche +11 more
doaj +1 more source