Results 101 to 110 of about 1,554 (181)

Genetic and molecular analysis of wing apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster.

, 2000
Mutations in the X-linked gene wings apart-like (wapl) result in late larval lethality associated with an unusual chromosome morphology. In brain cell metaphases of wapl mutants, sister chromatids of all chromosomes are aligned parallel to each other ...
GATTI, MAURIZIO, GANDHI R., GOLDBERG M.L., VERNI', Fiammetta   +3 more
core  

Studying meiotic cohesin in somatic cells reveals that Rec8-cohesin requires Stag3 and is regulated by Wapl and Sororin

, 2018
The DNA embracing, ring-shaped, multiprotein complex cohesin mediates sister chromatid cohesion and is stepwise displaced in mitosis by Wapl and Separase to facilitate anaphase.
Peter G. Wolf, Julia Kenzel, Brigitte Neumann, Olaf Stemmann, Alexander Cuba Ramos   +4 more
core   +1 more source

Pds5, Brca2 and Wapl differentially influence the levels of cohesin subunits and Nipped-B at gene regulatory sequences.

, 2018
(A) The violin plots show the distributions of Rad21 ChIP-seq enrichment values at promoters (PRO, blue) enhancers (ENH, yellow) and PREs (PRE, orange) in mock-treated control BG3 cells (mock) and cells depleted for Pds5 (iPds5).
Ziva Misulovin (262237), Michelle Pherson (3134739), Maria Gause (144614), Dale Dorsett (63431)   +3 more
core   +1 more source

Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins

, 2017
Mammalian genomes are spatially organized into compartments, topologically associating domains (TADs), and loops to facilitate gene regulation and other chromosomal functions. How compartments, TADs, and loops are generated is unknown.
Gordana Wutz, Peter Fraser, Nike Walther, Peters, Jan-Michael, Ellenberg, Jan, Muhar, Matthias, M Julius Hossain, Walther, Nike, Roman R Stocsits, Birgit Koch, Várnai, Csilla, Schoenfelder, Stefan, Fraser, Peter, Hossain, M Julius, Csilla Várnai, Várnai, Csilla; id_orcid, Wutz, Gordana, Stefan Schoenfelder, Stocsits, Roman R, David A Cisneros, Wen Tang, Gregor Jessberger, Kueblbeck, Moritz, Jan‐Michael Peters, Koch, Birgit, Zuber, Johannes, Matthias Muhar, Nagasaka, Kota, Peters, Jan‐Michael, Cisneros, David A, Jessberger, Gregor, Tang, Wen, Kota Nagasaka, Jan Ellenberg, Cisneros, David A.,, Moritz Kueblbeck, Johannes Zuber   +36 more
core   +1 more source

Synthetic Lethality between Cohesin and WNT Signaling Pathways in Diverse Cancer Contexts

Cells
Cohesin is a highly conserved ring-shaped complex involved in topologically embracing chromatids, gene expression regulation, genome compartmentalization, and genome stability maintenance.
Maria Michela Pallotta, Maddalena Di Nardo, Antonio Musio   +2 more
doaj   +1 more source

WAPL Gene [PDF]

, 2020
openaire   +1 more source

The relative levels of cohesin, Nipped-B, Pds5, Wapl and Brca2 vary between active promoters, enhancers and Polycomb Response Elements (PREs).

, 2018
The top diagram summarizes how active promoters (blue) extragenic enhancers (yellow) and PREs (orange) are defined as 500 bp sequences as described elsewhere [17, 19, 33]. There are 7,389 non-heterochromatic active promoters, 523 extragenic enhancers and
Ziva Misulovin (262237), Michelle Pherson (3134739), Maria Gause (144614), Dale Dorsett (63431)   +3 more
core   +1 more source

WAPL wt Allele [PDF]

, 2020
openaire   +1 more source

Regulation of Sister Chromatid Cohesion by ECO-1 and WAPL-1 during meiosis and mitosis

, 2015
Cohesin is a widely conserved, tetrameric protein complex that tethers replicated sister chromatids during meiosis and mitosis. Two cohesin subunits, SMC-1 and SMC-3, and a third subunit, the α-kleisin, form a ring proposed to encircle sister chromatids.
Schroeder, Kyle T
core  

Cohesin degradation is delayed in C(2)EN and Wapl mutants.

, 2014
(A) Images from live analysis of Rad21-EGFP dynamics in wild-type, C(2)EN, and waplC204 mutant neuroblast cells. Time 0∶00 equals anaphase onset and scale bars are 10 µm.
William Sullivan (37486), Christian S. Eichinger (641028), Alexandra Tavares (144746), Raquel A. Oliveira (641024), Mihailo Mirkovic (641026), Shaila Kotadia (641025), Katherine Bowlin (641027), Kim Nasmyth (71271)   +7 more
core   +1 more source