Results 121 to 130 of about 1,291 (151)

Structure of the human cohesin inhibitor Wapl [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2013
Cohesin, along with positive regulators, establishes sister-chromatid cohesion by forming a ring to circle chromatin. The wings apart-like protein (Wapl) is a key negative regulator of cohesin and forms a complex with precocious dissociation of sisters protein 5 (Pds5) to promote cohesin release from chromatin.
Chad Bräutigam, Susannah Rankin, Dominika Borek   +2 more
exaly   +3 more sources

Wapl is an essential regulator of chromatin structure and chromosome segregation [PDF]

Nature, 2013
Mammalian genomes contain several billion base pairs of DNA that are packaged in chromatin fibres. At selected gene loci, cohesin complexes have been proposed to arrange these fibres into higher-order structures, but how important this function is for determining overall chromosome architecture and how the process is regulated are not well understood ...
Jan Ellenberg, Antonio Tedeschi, Alipasha Vaziri   +2 more
exaly   +4 more sources

Sororin Mediates Sister Chromatid Cohesion by Antagonizing Wapl [PDF]

Cell, 2010
Sister chromatid cohesion is essential for chromosome segregation and is mediated by cohesin bound to DNA. Cohesin-DNA interactions can be reversed by the cohesion-associated protein Wapl, whereas a stably DNA-bound form of cohesin is thought to mediate cohesion. In vertebrates, Sororin is essential for cohesion and stable cohesin-DNA interactions, but
Alexander Schleiffer, René Ladurner, Karl Mechtler   +2 more
exaly   +4 more sources

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Unscheduled overexpression of human WAPL promotes chromosomal instability

Biochemical and Biophysical Research Communications, 2007
Previously, we have isolated and characterized a novel human gene termed human WAPL that has the characteristics of an oncogene in uterine cervical cancer. WAPL is inducible by human papillomavirus (HPV) E6 and E7 oncoproteins. On the other hand, recent studies have revealed that WAPL regulates sister chromatid resolution by controlling the association
Masahiko Kuroda, Hitoshi Satoh, Kosuke Oikawa   +2 more
exaly   +3 more sources

WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring

Science, 2023
Neural type–specific expression of clustered Protocadherin (Pcdh) proteins is essential for the establishment of connectivity patterns during brain development. In mammals, deterministic expression of the same Pcdh isoform promotes minimal overlap of tiled projections of serotonergic neuron axons throughout the brain, while stochastic expression of ...
Kiefer, Lea, Chiosso, Anna, Langen, Jennifer, Buckley, Alex, Gaudin, Simon, Rajkumar, Sandy M., Servito, Gabrielle Isabelle F., Cha, Elizabeth S., Vijay, Akshara, Yeung, Albert, Horta, Adan, Mui, Michael H., Canzio, Daniele   +12 more
exaly   +4 more sources

Conservation of Pacific Salmon: Response to Wainwright and Waples

Conservation Biology, 1998
*Northwest Indian Fisheries Commission, 6730 Martin Way East, Olympia, WA 98516, U.S.A., email kcurrens@nwifc.wa.gov †Division of Biological Sciences, University of Montana, Missoula, MT 59812, U.S.A. ‡Pacific Rivers Council, P.O. Box 10798, Eugene, OR 97440, U.S.A.
Kenneth P. Currens, Fred W. Allendorf, David Bayles, Daniel L. Bottom, Christopher A. Frissell, David Hankin, James A. Lichatowich, Patrick C. Trotter, Thomas A. Williams   +8 more
openaire   +1 more source

Distinct Population Segments and Congressional Intent: Reply to Waples

Conservation Biology, 2000
We reviewed the legislative and management history of distinct population segments (DPSs) from the U.S. Endangered Species Act (ESA) (Pennock & Dimmick 1997). We concluded that the U.S. Congress recognized cases in which the protection of biodiversity was best accomplished by the separate listing of populations within an evolutionary unit.
David S. Pennock, Walter W. Dimmick
openaire   +1 more source

Biochemical and Functional Assays of Human Cohesin-Releasing Factor Wapl

2016
During the cell cycle, duplicated sister chromatids become physically connected during S phase through a process called sister-chromatid cohesion. Cohesion is terminated during the metaphase-to-anaphase transition to trigger sister-chromatid segregation.
Ge, Zheng, Zhuqing, Ouyang, Hongtao, Yu
openaire   +2 more sources

[Research progress about Wapl gene].

Sheng li ke xue jin zhan [Progress in physiology], 2012
In Drosophila melanogasler,the wings apart-like (wapl) gene encodes a protein that regulates heterochromatin structure. Human wapl gene is human homolognue of wapl,they have same function. HWAPL is a cohesion-binding protein that affect chromosomal segregation.
Li-Xian, Cao, Zhong-Fei, Shen, Wei-Wei, Pan   +2 more
openaire   +1 more source

Normativity and the Meaning of Endangered : Response to Waples et al. 2007

Conservation Biology, 2007
There has been increased interest recently in better understanding the meaning of endangered species as defined in the 1973 U.S. Endangered Species Act (ESA). Waples et al. (2007) provide an account that is, in part, a reaction to a position presented by us in Vucetich et al. (2006). Here, we extend this discussion with comments focused on Waples et al.
Michael P, Nelson, John A, Vucetich, Michael K, Phillips   +2 more
openaire   +2 more sources