Wapl Controls the Dynamic Association of Cohesin with Chromatin [PDF]
Cell, 2006 SummaryCohesin establishes sister-chromatid cohesion from S phase until mitosis or meiosis. To allow chromosome segregation, cohesion has to be dissolved.
Alexander Schleiffer +2 more
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Sororin Mediates Sister Chromatid Cohesion by Antagonizing Wapl [PDF]
Cell, 2010 SummarySister chromatid cohesion is essential for chromosome segregation and is mediated by cohesin bound to DNA. Cohesin-DNA interactions can be reversed by the cohesion-associated protein Wapl, whereas a stably DNA-bound form of cohesin is thought to ...
Alexander Schleiffer +2 more
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The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension [PDF]
Cell, 2017 The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes.
Bas van Steensel +2 more
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A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis [PDF]
FEBS Letters, 2005 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an endocrine disruptor that produces a variety of toxic effects. We have isolated a mouse homolog of the hWAPL gene, termed mouse WAPL (mWAPL), as a target of TCDD by cDNA representational difference analysis
Masahiko Kuroda
exaly +4 more sources
WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring
Science, 2023 Diverse neural wiring patterns emerge from differential regulation of cohesin-mediated DNA loop-extrusion by WAPL, which functions as a rheostat of cohesin processivity and Pcdh isoform ...
Yeung, Albert +12 more
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Decreasing Wapl dosage partially corrects embryonic growth and brain transcriptome phenotypes in Nipbl +/− embryos [PDF]
Science Advances, 2022 Cohesin rings interact with DNA and modulate the expression of thousands of genes. NIPBL loads cohesin onto chromosomes, and WAPL takes it off. Haploinsufficiency for NIPBL causes a developmental disorder, Cornelia de Lange syndrome (CdLS), that is ...
Judith Kassis +2 more
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Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl [PDF]
Nature, 2017 Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin into chromatin loops and topologically associated domains, which have important roles in gene regulation and recombination. By binding to specific sequences, CTCF defines contact points for cohesin-mediated long-range chromosomal cis-interactions.
Antonio Tedeschi +2 more
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Wapl is an essential regulator of chromatin structure and chromosome segregation [PDF]
Nature, 2013 Mammalian genomes contain several billion base pairs of DNA that are packaged in chromatin fibres. At selected gene loci, cohesin complexes have been proposed to arrange these fibres into higher-order structures, but how important this function is for determining overall chromosome architecture and how the process is regulated are not well understood ...
Jan Ellenberg +2 more
exaly +4 more sources
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Unscheduled overexpression of human WAPL promotes chromosomal instability
Biochemical and Biophysical Research Communications, 2007Previously, we have isolated and characterized a novel human gene termed human WAPL that has the characteristics of an oncogene in uterine cervical cancer. WAPL is inducible by human papillomavirus (HPV) E6 and E7 oncoproteins. On the other hand, recent studies have revealed that WAPL regulates sister chromatid resolution by controlling the association
Masahiko Kuroda +2 more
exaly +3 more sources