Results 151 to 160 of about 1,554 (181)

A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis

FEBS Letters, 2005
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an endocrine disruptor that produces a variety of toxic effects. We have isolated a mouse homolog of the hWAPL gene, termed mouse WAPL (mWAPL), as a target of TCDD by cDNA representational difference analysis
Masahiko Kuroda, Kosuke Oikawa, Junsei Mimura   +2 more
exaly   +4 more sources

Wapl is an essential regulator of chromatin structure and chromosome segregation [PDF]

Nature, 2013
International audienceMammalian genomes contain several billion base pairs of DNA that are packaged in chromatin fibres. At selected gene loci, cohesin complexes have been proposed to arrange these fibres into higher-order structures1, 2, 3, 4, 5, 6, 7 ...
Antonio Tedeschi, GORDANA Wütz, Markus Jaritz   +2 more
exaly   +5 more sources

WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring

Science, 2023
Diverse neural wiring patterns emerge from differential regulation of cohesin-mediated DNA loop-extrusion by WAPL, which functions as a rheostat of cohesin processivity and Pcdh isoform ...
Yeung, Albert, Rajkumar, Sandy M., Horta, Adan, Canzio, Daniele, Gaudin, Simon, Vijay, Akshara, Buckley, Alex, Langen, Jennifer, Servito, Gabrielle Isabelle F., Mui, Michael H., Chiosso, Anna, Cha, Elizabeth S., Kiefer, Lea   +12 more
exaly   +5 more sources

Decreasing Wapl dosage partially corrects embryonic growth and brain transcriptome phenotypes in Nipbl +/− embryos [PDF]

Science Advances, 2022
Cohesin rings interact with DNA and modulate the expression of thousands of genes. NIPBL loads cohesin onto chromosomes, and WAPL takes it off. Haploinsufficiency for NIPBL causes a developmental disorder, Cornelia de Lange syndrome (CdLS), that is ...
Connor M Kean, Christopher J Tracy, Apratim Mitra   +2 more
exaly   +2 more sources

Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl [PDF]

Nature, 2017
Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin into chromatin loops and topologically associated domains, which have important roles in gene regulation and recombination. By binding to specific sequences, CTCF defines contact points for cohesin-mediated long-range chromosomal cis-interactions.
Georg A Busslinger, Roman R Stocsits, Elin Axelsson   +2 more
exaly   +4 more sources

Structure of the human cohesin inhibitor Wapl [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2013
Cohesin, along with positive regulators, establishes sister-chromatid cohesion by forming a ring to circle chromatin. The wings apart-like protein (Wapl) is a key negative regulator of cohesin and forms a complex with precocious dissociation of sisters protein 5 (Pds5) to promote cohesin release from chromatin.
Ge Zheng, Jianhua Song, Dominika Borek   +2 more
exaly   +3 more sources

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Unscheduled overexpression of human WAPL promotes chromosomal instability

Biochemical and Biophysical Research Communications, 2007
Previously, we have isolated and characterized a novel human gene termed human WAPL that has the characteristics of an oncogene in uterine cervical cancer. WAPL is inducible by human papillomavirus (HPV) E6 and E7 oncoproteins. On the other hand, recent studies have revealed that WAPL regulates sister chromatid resolution by controlling the association
Kosuke Oikawa, Chizuko Nishida-Umehara, Yoichi Matsuda   +2 more
exaly   +3 more sources

Conservation of Pacific Salmon: Response to Wainwright and Waples

Conservation Biology, 1998
*Northwest Indian Fisheries Commission, 6730 Martin Way East, Olympia, WA 98516, U.S.A., email kcurrens@nwifc.wa.gov †Division of Biological Sciences, University of Montana, Missoula, MT 59812, U.S.A. ‡Pacific Rivers Council, P.O. Box 10798, Eugene, OR 97440, U.S.A.
Kenneth P. Currens, Fred W. Allendorf, David Bayles, Daniel L. Bottom, Christopher A. Frissell, David Hankin, James A. Lichatowich, Patrick C. Trotter, Thomas A. Williams   +8 more
openaire   +1 more source

Distinct Population Segments and Congressional Intent: Reply to Waples

Conservation Biology, 2000
We reviewed the legislative and management history of distinct population segments (DPSs) from the U.S. Endangered Species Act (ESA) (Pennock & Dimmick 1997). We concluded that the U.S. Congress recognized cases in which the protection of biodiversity was best accomplished by the separate listing of populations within an evolutionary unit.
David S. Pennock, Walter W. Dimmick
openaire   +1 more source

Biochemical and Functional Assays of Human Cohesin-Releasing Factor Wapl

2016
During the cell cycle, duplicated sister chromatids become physically connected during S phase through a process called sister-chromatid cohesion. Cohesion is terminated during the metaphase-to-anaphase transition to trigger sister-chromatid segregation.
Ge, Zheng, Zhuqing, Ouyang, Hongtao, Yu
openaire   +2 more sources