Results 81 to 90 of about 1,661 (174)

EBV Latency Programs: Molecular and Epigenetic Regulation and Its Role in Disease Pathogenesis

Journal of Medical Virology, Volume 97, Issue 7, July 2025.
ABSTRACT Epstein‐Barr virus (EBV) asymptomatically infects over 95% of the global population, and poses a great threat to human health. This review summarizes the complex mechanisms underlying EBV latency programs and their roles in both viral persistence and disease development.
Likang Lyu, Qian Li, Chong Wang
wiley   +1 more source

WAPL knockdown-associated biological processes rescued by co-depletion with NIPBL.

, 2022
Top 10 GO Biological Processes for WAPL DEGs rescued in the double knockdown condition sorted by adjusted p-value. (DOCX)
Rebecca Yunker (14197613), Parisha P. Shah (9380961), Eric F. Joyce (7900052), Rajan Jain (422776), Karen Adelman (4540336), Jennifer M. Luppino (14197610), Yemin Lan (330697), Andrew Field (12393694), Son C. Nguyen (1332762), Richard J. Abdill (6719147), Daniel S. Park (14117041)   +10 more
core   +1 more source

Effect of benzo[a]pyrene exposure during pregnancy on learning and memory functions of rat offspring and expression levels of related genes

环境与职业医学
BackgroundPolycyclic aromatic hydrocarbons represented by benzo[a]pyrene are among the most significant occupational and environmental pollutants. Exposure to benzo[a]pyrene during pregnancy can cause delayed intellectual development in offspring, and ...
Jingya SHI, Siyu WANG, Xutao GAO, Jisheng NIE   +3 more
doaj   +1 more source

In Favor of Establishment: Regulation of Chromatid Cohesion in Plants

Frontiers in Plant Science, 2017
In eukaryotic organisms, the correct regulation of sister chromatid cohesion, whereby sister chromatids are paired and held together, is essential for accurate segregation of the sister chromatids and homologous chromosomes into daughter cells during ...
Pablo Bolaños-Villegas, Kuntal De, Mónica Pradillo, Desheng Liu, Christopher A. Makaroff   +4 more
doaj   +1 more source

Migration of Deep Convection Center in Subpolar North Atlantic Around 6 ka Suggested by a Dinocyst Proxy of Mixed Layer Depth

Paleoceanography and Paleoclimatology, Volume 40, Issue 6, June 2025.
Abstract This study explores the relationship between dinoflagellate cyst (dinocyst) assemblages and the mixed layer depth (MLD) using canonical correspondence analyses. Our results suggest that wintertime deepening of MLD, in response to deep convection events, can influence dinocyst assemblages and especially the relative abundance of ...
Xiner Wu, Anne de Vernal, Estelle Allan
wiley   +1 more source

Quinoline ATP Synthase Inhibitors with Activity Against Multidrug Resistant Acinetobacter baumannii and Pseudomonas aeruginosa

ChemMedChem, Volume 20, Issue 10, May 19, 2025.
Targeting ATP synthase in Gram‐negative pathogens. Presented is the first disclosure of quinoline‐derived antibiotics inhibiting multidrug resistant Acinetobacter baumannii ATP synthase and expansion of the structure activity relationship profile of Pseudomonas aeruginosa ATP synthase inhibitors.
Katie T. Ward, Alexander P. L. Williams, Angelina L. Dennison, Lena Aamir, Darien L. Allen, Britza Chavez‐Arellano, Toni A. Marchlewski, Mars L. Zappia, Amanda L. Wolfe, P. Ryan Steed   +9 more
wiley   +1 more source

Cohesin acetylation and Wapl‐Pds5 oppositely regulate translocation of cohesin along DNA

The EMBO Journal, 2016
Cohesin is a ring-shaped protein complex that plays a crucial role in sister chromatid cohesion and gene expression. The dynamic association of cohesin with chromatin is essential for these functions. However, the exact nature of cohesin dynamics, particularly cohesin translocation, remains unclear.
Mai Kanke, Eri Tahara, Pim J Huis in't Veld, Tomoko Nishiyama   +3 more
openaire   +3 more sources

Absolute quantification of cohesin, CTCF and their regulators in human cells

eLife, 2019
The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. TADs and many loops are formed by cohesin and positioned by CTCF. In proliferating cells,
Johann Holzmann, Antonio Z Politi, Kota Nagasaka, Merle Hantsche-Grininger, Nike Walther, Birgit Koch, Johannes Fuchs, Gerhard Dürnberger, Wen Tang, Rene Ladurner, Roman R Stocsits, Georg A Busslinger, Béla Novák, Karl Mechtler, Iain Finley Davidson, Jan Ellenberg, Jan-Michael Peters   +16 more
doaj   +1 more source

Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.

PLoS ONE, 2020
In a process linked to DNA replication, duplicated chromosomes are entrapped in large, circular cohesin complexes and functional sister chromatid cohesion (SCC) is established by acetylation of the SMC3 cohesin subunit.
Atiq Faramarz, Jesper A Balk, Janne J M van Schie, Anneke B Oostra, Cherien A Ghandour, Martin A Rooimans, Rob M F Wolthuis, Job de Lange   +7 more
doaj   +1 more source

Current Advances in Genome Modeling Across Length Scales

WIREs Computational Molecular Science, Volume 15, Issue 3, May/June 2025.
ABSTRACT The physical organization of DNA within the nucleus is fundamental to a wide range of biological processes. The experimental investigation of the structure of genomic DNA remains challenging due to its large size and hierarchical arrangement. These challenges present considerable opportunities for combined experimental and modeling approaches.
Eric R. Schultz, Jay L. Kaplan, Yiheng Wu, Soren Kyhl, Rebecca Willett, Juan J. de Pablo   +5 more
wiley   +1 more source