Results 81 to 90 of about 1,554 (181)

Effect of benzo[a]pyrene exposure during pregnancy on learning and memory functions of rat offspring and expression levels of related genes

环境与职业医学
BackgroundPolycyclic aromatic hydrocarbons represented by benzo[a]pyrene are among the most significant occupational and environmental pollutants. Exposure to benzo[a]pyrene during pregnancy can cause delayed intellectual development in offspring, and ...
Jingya SHI, Siyu WANG, Xutao GAO, Jisheng NIE   +3 more
doaj   +1 more source

Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.

PLoS ONE, 2020
In a process linked to DNA replication, duplicated chromosomes are entrapped in large, circular cohesin complexes and functional sister chromatid cohesion (SCC) is established by acetylation of the SMC3 cohesin subunit.
Atiq Faramarz, Jesper A Balk, Janne J M van Schie, Anneke B Oostra, Cherien A Ghandour, Martin A Rooimans, Rob M F Wolthuis, Job de Lange   +7 more
doaj   +1 more source

Current Advances in Genome Modeling Across Length Scales

WIREs Computational Molecular Science, Volume 15, Issue 3, May/June 2025.
ABSTRACT The physical organization of DNA within the nucleus is fundamental to a wide range of biological processes. The experimental investigation of the structure of genomic DNA remains challenging due to its large size and hierarchical arrangement. These challenges present considerable opportunities for combined experimental and modeling approaches.
Eric R. Schultz, Jay L. Kaplan, Yiheng Wu, Soren Kyhl, Rebecca Willett, Juan J. de Pablo   +5 more
wiley   +1 more source

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion

, 2020
Nuclear processes, such as V(D)J recombination, are orchestrated by the three-dimensional organization of chromosomes at multiple levels, including compartments1 and topologically associated domains (TADs)2,3 consisting of chromatin loops4.
Markus Jaritz, Bönelt, Peter, Busslinger, Meinrad, Gordana Wutz, Hill, Louisa, Peters, Jan-Michael, Meinrad Busslinger, Tagoh, Hiromi, Karina Schindler, Ebert, Anja, Peter Bönelt, Wutz, Gordana, Maria Fischer, Schindler, Karina, Kostanova-Poliakova, Daniela, Daniela Kostanova-Poliakova, Jaritz, Markus, Nagasaka, Kota, Louisa Hill, Jan-Michael Peters, Kota Nagasaka, Anja Ebert, Fischer, Maria, Hiromi Tagoh, Qiong Sun, Sun, Qiong   +25 more
core   +1 more source

Rad61/Wpl1 (Wapl), a cohesin regulator, controls chromosome compaction during meiosis [PDF]

Nucleic Acids Research, 2016
Meiosis-specific cohesin, required for the linking of the sister chromatids, plays a critical role in various chromosomal events during meiotic prophase I, such as chromosome morphogenesis and dynamics, as well as recombination. Rad61/Wpl1 (Wapl in other organisms) negatively regulates cohesin functions.
Challa, Kiran, Lee, Min-Su, Shinohara, Miki, Kim, Keun P., Shinohara, Akira   +4 more
openaire   +2 more sources

Absolute quantification of cohesin, CTCF and their regulators in human cells

eLife, 2019
The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. TADs and many loops are formed by cohesin and positioned by CTCF. In proliferating cells,
Johann Holzmann, Antonio Z Politi, Kota Nagasaka, Merle Hantsche-Grininger, Nike Walther, Birgit Koch, Johannes Fuchs, Gerhard Dürnberger, Wen Tang, Rene Ladurner, Roman R Stocsits, Georg A Busslinger, Béla Novák, Karl Mechtler, Iain Finley Davidson, Jan Ellenberg, Jan-Michael Peters   +16 more
doaj   +1 more source

Effectiveness of interventions for improving educational outcomes for people with disabilities in low‐ and middle‐income countries: A systematic review

Campbell Systematic Reviews, Volume 21, Issue 1, March 2025.
Abstract Background People with disabilities are consistently falling behind in educational outcomes compared to their peers without disabilities, whether measured in terms of school enrolment, school completion, mean years of schooling, or literacy levels.
Xanthe Hunt, Ashrita Saran, Howard White, Hannah Kuper   +3 more
wiley   +1 more source

Nuclear Overexpression of SAMHD1 Induces M Phase Stalling in Hepatoma Cells and Suppresses HCC Progression by Interacting with the Cohesin Complex

Advanced Science, Volume 12, Issue 6, February 10, 2025.
This study uncovers the key role for nuclear SAMHD1 in slowing hepatocellular carcinoma (HCC) progression. Elevated nuclear SAMHD1 levels in tumors correlate with favorable prognosis, and hepatocyte‐specific SAMHD1 knockout in mice accelerates tumor growth. Mechanistically, SAMHD1 interacts with the nuclear cohesin complex to stall mitosis, independent
Juntang Shao, Wei Wang, Shiyu Li, Guangfa Yin, Lili Han, Xinyu Wang, Meng Cai, Tao Yang, Ying Wang, Wenyan Qu, Yanhong Jiao, Peng Wang, Hanyang Xu, Xu Zhu, Songcheng Ying, Sa Xu, Qiang Sheng, Jian Fang, Tongcui Jiang, Chuansheng Wei, Yujun Shen, Yuxian Shen   +21 more
wiley   +1 more source

Crystal Structure of the Cohesin Gatekeeper Pds5 and in Complex with Kleisin Scc1

Cell Reports, 2016
Sister chromatid cohesion is mediated by cohesin, whose Smc1, Smc3, and kleisin (Scc1) subunits form a ring structure that entraps sister DNAs. The ring is opened either by separase, which cleaves Scc1 during anaphase, or by a releasing activity ...
Byung-Gil Lee, Maurici B. Roig, Marijke Jansma, Naomi Petela, Jean Metson, Kim Nasmyth, Jan Löwe   +6 more
doaj   +1 more source

Cohesin Can Remain Associated with Chromosomes during DNA Replication

Cell Reports, 2017
To ensure disjunction to opposite poles during anaphase, sister chromatids must be held together following DNA replication. This is mediated by cohesin, which is thought to entrap sister DNAs inside a tripartite ring composed of its Smc and kleisin (Scc1)
James D.P. Rhodes, Judith H.I. Haarhuis, Jonathan B. Grimm, Benjamin D. Rowland, Luke D. Lavis, Kim A. Nasmyth   +5 more
doaj   +1 more source