Results 61 to 70 of about 1,554 (181)
Epigenetics & Chromatin, 2022 Background The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or STAG2 subunit, and two versions of
Ana Cuadrado +6 more
doaj +1 more source
Pds5 influences Wapl and Nipped-B binding at DNA replication origins with little effect on Brca2.
, 2018 (A) Metaorigin plot of Wapl to Rad21 ratio in control cells (Mock, blue) and cells depleted for Pds5 (iPds5, red). (B) Left panel is meta-origin analysis of Wapl ChIP-seq enrichment in control cells (Wapl, blue) and cells depleted for Pds5 (Wapl iPds5 ...
Ziva Misulovin (262237) +3 more
core +1 more source
Nature Communications, 2019 Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.
V. Pragathi Masamsetti +10 more
doaj +1 more source
Diploid origins and early genome stabilization in the allotetraploid Arabidopsis suecica
New Phytologist, Volume 249, Issue 1, Page 524-538, January 2026.Summary Polyploidization, followed by genome downsizing, is a recurrent evolutionary cycle that dramatically reshapes genome structure. Newly formed polyploids must quickly adjust their cell division machinery to maintain stable chromosome inheritance, while long‐term stabilization involves rediploidization, returning the genome to a diploid‐like state.
Robin Burns +6 more
wiley +1 more source
Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion [PDF]
Nature Structural & Molecular Biology, 2014 Orderly termination of sister-chromatid cohesion during mitosis is critical for accurate chromosome segregation. During prophase, mitotic kinases phosphorylate cohesin and its protector sororin, triggering Wapl-dependent cohesin release from chromosome arms.
Hara, Kodai +7 more
openaire +2 more sources
Angewandte Chemie, Volume 137, Issue 1, January 2, 2025.Weak interaction of thieno[3,2‐b]pyridine with the kinase hinge region allows for design of highly selective inhibitors of underexplored kinases with variable binding modes. The newly identified chemical biology probe MU1920 targets the kinase Haspin with exquisite kinome‐wide selectivity.
Paula Martín Moyano +15 more
wiley +2 more sources
Journal of Phycology, Volume 61, Issue 6, Page 1681-1698, December 2025.Abstract As climate change is having increasingly visible impacts on coastal regions, it is urgent to better understand its effects on the state of ecosystems and the services they provide. To assess the direction and magnitude of change in the high‐use waters of the Sept‐Îles region in the Gulf of St‐Lawrence, we sampled 35 sites along the coast and ...
Emilie Arseneault +1 more
wiley +1 more source
, 2006 BACKGROUND: The linkage between duplicated chromosomes (sister chromatids) is established during S phase by the action of cohesin, a multisubunit complex conserved from yeast to humans.
Rita Gandhi +8 more
core +1 more source
WAPL knockdown-associated biological processes rescued by co-depletion with NIPBL.
, 2022 Top 10 GO Biological Processes for WAPL DEGs rescued in the double knockdown condition sorted by adjusted p-value. (DOCX)
Rebecca Yunker (14197613) +10 more
core +1 more source
Animals, 2023 Canine lymphoma (CL) is one of the most common malignant tumors in dogs. The cause of CL remains unclear. Genetic mutations that have been suggested as possible causes of CL are not fully understood.
Sungryong Kim +5 more
doaj +1 more source