Results 61 to 70 of about 1,661 (174)

Replication factor C complexes play unique pro- and anti-establishment roles in sister chromatid cohesion. [PDF]

PLoS ONE, 2010
Recent studies have lead to a rapid expansion of sister chromatid cohesion pathways. Of particular interest is the growth in classifications of anti-establishment factors-now including those that are cohesin-associated (Rad61/WAPL and Pds5) or DNA ...
Marie E Maradeo, Robert V Skibbens
doaj   +1 more source

Current Challenges of Transcription Compartmentalization Research

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley   +1 more source

Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release

, 2021
The alternative PCNA loader containing CTF18-DCC1-CTF8 facilitates sister chromatid cohesion (SCC) by poorly defined mechanisms. Here we found that in DT40 cells, CTF18 acts complementarily with the Warsaw breakage syndrome DDX11 helicase in mediating ...
Branzei D, Abe T, Kawasumi R, Hirota K, Miyata K, Psakhye I   +5 more
core   +2 more sources

Interaction Between Rec8 and Mis4 Is Required for Axis‐Loop Chromatin Formation and Homologous Chromosome Recombination During Meiosis

Genes to Cells, Volume 31, Issue 4, July 2026.
We identified a Mis4 cohesin loader mutant that is specifically defective in chromatin axis formation and homologous recombination while retaining normal sister chromatid cohesion. The mis4‐LR mutant, carrying the L1150S and R1159G amino acid substitutions, exhibited reduced interaction between Mis4 and Rec8, suggesting a meiosis‐specific role for the ...
Takeshi Sakuno, Yasuto Murayama, Tokuko Haraguchi, Yasushi Hiraoka   +3 more
wiley   +1 more source

Pds5 influences Wapl and Nipped-B binding at DNA replication origins with little effect on Brca2.

, 2018
(A) Metaorigin plot of Wapl to Rad21 ratio in control cells (Mock, blue) and cells depleted for Pds5 (iPds5, red). (B) Left panel is meta-origin analysis of Wapl ChIP-seq enrichment in control cells (Wapl, blue) and cells depleted for Pds5 (Wapl iPds5 ...
Ziva Misulovin (262237), Michelle Pherson (3134739), Maria Gause (144614), Dale Dorsett (63431)   +3 more
core   +1 more source

Pds5A and Pds5B Display Non-redundant Functions in Mitosis and Their Loss Triggers Chk1 Activation

Frontiers in Cell and Developmental Biology, 2020
BackgroundPds5 is an abundant HEAT-repeat-containing protein that binds to cohesin and mediates sister chromatid cohesion. In vertebrates, Pds5A and Pds5B are known to protect DNA replication fork, as their loss leads to DNA damage.
Naif Al-Jomah, Naif Al-Jomah, Lubinda Mukololo, Lubinda Mukololo, Awais Anjum, Awais Anjum, Mohammed Al Madadha, Mohammed Al Madadha, Raj Patel   +8 more
doaj   +1 more source

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

Developmental Dynamics, Volume 255, Issue 4, Page 403-416, April 2026.
Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez, Niusha Banoukh, Fiona Mensching, Robert V. Skibbens, M. Kathryn Iovine   +4 more
wiley   +1 more source

Roles of Wapl in cell cycle progression and chromosome segregation [PDF]

, 2010
In der mitotischen Zellteilung hängt die Segregation der Chromosomen von der Kohäsion der Schwesterchromatiden ab, die durch den Proteinkomplex Cohesin hergestellt wird. Die Chromosomenkohäsion ermöglicht die bipolare Orientierung der Chromosomen auf der
Tedeschi, Antonio
core  

WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation [PDF]

, 2021
The cohesin complex has an essential role in maintaining genome organization. However, its role in gene regulation remains largely unresolved. Here we report that the cohesin release factor WAPL creates a pool of free cohesin, in a process known as ...
Elphѐge P. Nora, Liu, Ning Qing, de Wit, Elzo, Teun van den Brand, Luca Braccioli, Teunissen, Hans, Marijne M. G. A. Schijns, Elzo de Wit, Ning Qing Liu, Michela Maresca, Bruneau, Benoit G, Maresca, Michela, Nora, Elphѐge P, Hans Teunissen, Schijns, Marijne MGA, Benoit G. Bruneau, van den Brand, Teun, Braccioli, Luca   +17 more
core   +1 more source

Partial depletion of NIPBL or WAPL separate the role of cohesin in chromatin folding from chromosome segregation.

, 2022
(A) Cartoon depicting the roles of the two opposing cohesin regulators; NIPBL loads cohesin onto chromatin and is required for loop extrusion whereas WAPL opens the ring and removes it. (B) Fluorescent western blot to NIPBL (top band, see arrow) and WAPL
Rebecca Yunker (14197613), Parisha P. Shah (9380961), Eric F. Joyce (7900052), Rajan Jain (422776), Karen Adelman (4540336), Jennifer M. Luppino (14197610), Yemin Lan (330697), Andrew Field (12393694), Son C. Nguyen (1332762), Richard J. Abdill (6719147), Daniel S. Park (14117041)   +10 more
core   +1 more source