Results 41 to 50 of about 1,554 (181)
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface
eLife, 2021 Dramatic change in chromosomal DNA morphology between interphase and mitosis is a defining features of the eukaryotic cell cycle. Two types of enzymes, namely cohesin and condensin confer the topology of chromosomal DNA by extruding DNA loops.
Martin Houlard +9 more
doaj +1 more source
eLife, 2022 Cohesin organizes the genome by forming intra-chromosomal loops and inter-sister chromatid linkages. During gamete formation by meiosis, chromosomes are reshaped to support crossover recombination and two consecutive rounds of chromosome segregation ...
Rachael E Barton +3 more
doaj +1 more source
NIPBL and WAPL regulate the expression of unique and shared sets of genes.
, 2022 (A) The log2(fold change) of genes after NIPBL knockdown versus their significance. DEGs are in green (999 up, 878 down) and non-significantly changed genes (nonDEGs, adjusted p-value > 0.01) are in grey.
Rebecca Yunker (14197613) +10 more
core +1 more source
WAPL restricts chromatin loop extension.
, 2022 HiC Contact map comparing significant interactions identified in WT (a) and ΔWAPL HAP1 (b) cells at 10kb fragment size. Black pixels are significant interactions identified by MaxHiC at P-value c) Distance distribution of significant interactions ...
Hamid Alinejad-Rokny (518381) +6 more
core +1 more source
SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis
Nature Communications, 2019 During cell division, Soronin antagonises WAPL to prevent premature loss of sister chromatid cohesion. Here the authors show that, despite a lack of sequence similarity, the Arabidopsis SWI1 protein functions as a novel Soronin-like WAPL antagonist ...
Chao Yang +6 more
doaj +1 more source
Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1
eLife, 2019 Cohesin’s association with chromosomes is determined by loading dependent on the Scc2/4 complex and release due to Wapl. We show here that Scc2 also actively maintains cohesin on chromosomes during G1 in S. cerevisiae cells. It does so by blocking a Wapl-
Madhusudhan Srinivasan +8 more
doaj +1 more source
Analysis of WAPL-1 and AIR-2 activity in condensin I mutants.
, 2018 (A) Immunofluorescence analysis of H3S10Ph (red) in wild type and dpy-28(tm3535) males. DNA is stained with DAPI (blue). H3S10Ph is clearly detectable in diakinesis through metaphase, but levels in pachytene are undetectable both in wild type and in ...
Györgyi Csankovszki (202404) +5 more
core +1 more source
Evidence for a Selective Sweep in the wapl Region of Drosophila melanogaster [PDF]
Genetics, 2006 Abstract A scan of the X chromosome of a European Drosophila melanogaster population revealed evidence for the recent action of positive directional selection at individual loci. In this study we analyze one such region that showed no polymorphism in the genome scan (located in cytological division 2C10–2E1).
Steffen, Beisswanger +2 more
openaire +2 more sources
RBMX: A Regulator for Maintenance and Centromeric Protection of Sister Chromatid Cohesion
Cell Reports, 2012 Cohesion is essential for the identification of sister chromatids and for the biorientation of chromosomes until their segregation. Here, we have demonstrated that an RNA-binding motif protein encoded on the X chromosome (RBMX) plays an essential role in
Sachihiro Matsunaga +12 more
doaj +1 more source
eLife, 2023 The cohesin complex plays essential roles in chromosome segregation, 3D genome organisation, and DNA damage repair through its ability to modify DNA topology.
Maikel Castellano-Pozo +10 more
doaj +1 more source