Results 41 to 50 of about 1,291 (151)

Evidence for a Selective Sweep in the wapl Region of Drosophila melanogaster [PDF]

Genetics, 2006
Abstract A scan of the X chromosome of a European Drosophila melanogaster population revealed evidence for the recent action of positive directional selection at individual loci. In this study we analyze one such region that showed no polymorphism in the genome scan (located in cytological division 2C10–2E1).
Steffen, Beisswanger, Wolfgang, Stephan, David, De Lorenzo   +2 more
openaire   +2 more sources

RBMX: A Regulator for Maintenance and Centromeric Protection of Sister Chromatid Cohesion

Cell Reports, 2012
Cohesion is essential for the identification of sister chromatids and for the biorientation of chromosomes until their segregation. Here, we have demonstrated that an RNA-binding motif protein encoded on the X chromosome (RBMX) plays an essential role in
Sachihiro Matsunaga, Hideaki Takata, Akihiro Morimoto, Kayoko Hayashihara, Tsunehito Higashi, Kouhei Akatsuchi, Eri Mizusawa, Mariko Yamakawa, Mamoru Ashida, Tomoko M. Matsunaga, Takachika Azuma, Susumu Uchiyama, Kiichi Fukui   +12 more
doaj   +1 more source

WAPL-Mediated Removal of Cohesin Protects against Segregation Errors and Aneuploidy [PDF]

Current Biology, 2013
The classical X shape of mitotic human chromosomes is the consequence of two distinct waves of cohesin removal. First, during prophase and prometaphase, the bulk of cohesin is driven from chromosome arms by the cohesin antagonist WAPL. This arm-specific cohesin removal is referred to as the prophase pathway [1-4].
Haarhuis, Judith H.I., Elbatsh, Ahmed M.O., van den Broek, Bram, Camps, Daniel, Erkan, Hasan, Jalink, Kees, Medema, René H., Rowland, Benjamin D.   +7 more
openaire   +2 more sources

The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

eLife, 2023
The cohesin complex plays essential roles in chromosome segregation, 3D genome organisation, and DNA damage repair through its ability to modify DNA topology.
Maikel Castellano-Pozo, Georgios Sioutas, Consuelo Barroso, Josh P Prince, Pablo Lopez-Jimenez, Joseph Davy, Angel-Luis Jaso-Tamame, Oliver Crawley, Nan Shao, Jesus Page, Enrique Martinez-Perez   +10 more
doaj   +1 more source

Replication factor C complexes play unique pro- and anti-establishment roles in sister chromatid cohesion. [PDF]

PLoS ONE, 2010
Recent studies have lead to a rapid expansion of sister chromatid cohesion pathways. Of particular interest is the growth in classifications of anti-establishment factors-now including those that are cohesin-associated (Rad61/WAPL and Pds5) or DNA ...
Marie E Maradeo, Robert V Skibbens
doaj   +1 more source

Current Challenges of Transcription Compartmentalization Research

Advanced Science, EarlyView.
Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley   +1 more source

Biogeochemical, sedimentological and dinoflagellate‐based reconstruction of the Holocene palaeoenvironment of the east Limfjord, Denmark

Boreas, EarlyView.
To assess how the eastern part of the Limfjord system has changed over the Holocene, relative to the wider Limfjord and western Baltic region, a sedimentary succession spanning c. 9600–150 cal. a BP was collected from Nibe Bredning, near Sebbersund, from a shallow coastal inlet along the eastern connection between the Limfjord and the Kattegat (north ...
Gabriella M. Weiss, Jonathan P. Lewis, Paula J. Reimer, David B. Ryves, Peter Rasmussen, Jesper Olsen   +5 more
wiley   +1 more source

HP1 Promotes the Centromeric Localization of ATRX and Protects Cohesion by Interfering Wapl Activity in Mitosis

Frontiers in Bioscience-Landmark
Background: α thalassemia/mental retardation syndrome X-linked (ATRX) serves as a part of the sucrose nonfermenting 2 (SNF2) chromatin-remodeling complex.
Erchen Zhang, Lei Peng, Kejia Yuan, Zexian Ding, Qi Yi   +4 more
doaj   +1 more source

Pds5A and Pds5B Display Non-redundant Functions in Mitosis and Their Loss Triggers Chk1 Activation

Frontiers in Cell and Developmental Biology, 2020
BackgroundPds5 is an abundant HEAT-repeat-containing protein that binds to cohesin and mediates sister chromatid cohesion. In vertebrates, Pds5A and Pds5B are known to protect DNA replication fork, as their loss leads to DNA damage.
Naif Al-Jomah, Naif Al-Jomah, Lubinda Mukololo, Lubinda Mukololo, Awais Anjum, Awais Anjum, Mohammed Al Madadha, Mohammed Al Madadha, Raj Patel   +8 more
doaj   +1 more source

Interaction Between Rec8 and Mis4 Is Required for Axis‐Loop Chromatin Formation and Homologous Chromosome Recombination During Meiosis

Genes to Cells, Volume 31, Issue 4, July 2026.
We identified a Mis4 cohesin loader mutant that is specifically defective in chromatin axis formation and homologous recombination while retaining normal sister chromatid cohesion. The mis4‐LR mutant, carrying the L1150S and R1159G amino acid substitutions, exhibited reduced interaction between Mis4 and Rec8, suggesting a meiosis‐specific role for the ...
Takeshi Sakuno, Yasuto Murayama, Tokuko Haraguchi, Yasushi Hiraoka   +3 more
wiley   +1 more source