Results 21 to 30 of about 1,661 (174)

Sororin is an evolutionary conserved antagonist of WAPL

Nature Communications
Cohesin mediates sister chromatid cohesion to enable chromosome segregation and DNA damage repair. To perform these functions, cohesin needs to be protected from WAPL, which otherwise releases cohesin from DNA.
Ignacio Prusén Mota, Marta Galova, Alexander Schleiffer, Tan-Trung Nguyen, Ines Kovacikova, Carolina Farias Saad, Gabriele Litos, Tomoko Nishiyama, Juraj Gregan, Jan-Michael Peters, Peter Schlögelhofer   +10 more
doaj   +5 more sources

Chromosomal localization of cohesin is differentially regulated by WIZ, WAPL, and G9a

BMC Genomics, 2022
Background The cohesin complex is essential for proper chromosome structure and gene expression. Defects in cohesin subunits and regulators cause changes in cohesin complex dynamics and thereby alter three-dimensional genome organization.
Megan Justice, Audra F. Bryan, Juanita C. Limas, Jeanette Gowen Cook, Jill M. Dowen   +4 more
doaj   +3 more sources

Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers. [PDF]

Nucleic Acids Res
Interphase chromosomes are mainly shaped by loop extrusion and compartmentalisation mechanisms. However, their temporal component and cause-effect relationships remain largely unknown.
Liu NQ, Magnitov M, Schijns MMGA, van Schaik T, Teunissen H, van Steensel B, de Wit E.   +6 more
europepmc   +5 more sources

WAPL-Mediated Removal of Cohesin Protects against Segregation Errors and Aneuploidy [PDF]

Current Biology, 2013
SummaryThe classical X shape of mitotic human chromosomes is the consequence of two distinct waves of cohesin removal. First, during prophase and prometaphase, the bulk of cohesin is driven from chromosome arms by the cohesin antagonist WAPL.
Haarhuis, Judith H.I., van den Broek, Bram, Erkan, Hasan, Medema, René H., Rowland, Benjamin D., Elbatsh, Ahmed M.O., Jalink, Kees, Camps, Daniel   +7 more
core   +4 more sources

HP1 Promotes the Centromeric Localization of ATRX and Protects Cohesion by Interfering Wapl Activity in Mitosis

Frontiers in Bioscience
Background: α thalassemia/mental retardation syndrome X-linked (ATRX) serves as a part of the sucrose nonfermenting 2 (SNF2) chromatin-remodeling complex.
Erchen Zhang, Lei Peng, Kejia Yuan, Zexian Ding, Qi Yi   +4 more
exaly   +3 more sources

The DNA loop release factor WAPL suppresses Epstein-Barr virus latent membrane protein expression to maintain the highly restricted latency I program. [PDF]

PLoS Pathogens
Epstein-Barr virus (EBV) uses latency programs to colonize the memory B-cell reservoir, and each program is associated with human malignancies. However, knowledge remains incomplete of epigenetic mechanisms that maintain the highly restricted latency I ...
Laura A Murray-Nerger, Davide Maestri, Xiang Liu, Zhixuan Li, Nina R Auld, Italo Tempera, Mingxiang Teng, Benjamin E Gewurz   +7 more
doaj   +2 more sources

Cross-platform Hi-C meta-analysis identifies functional insulators that actively block enhancer-promoter interactions [PDF]

Nature Communications
The function of topologically associating domain (TAD) boundaries as transcriptional insulators remains a fundamental controversy in genome biology. Here, we demonstrate that bona fide Functional Insulators (FINs) should be defined dynamically by their ...
Jian Cui, Wanying Xu, Xiuyuan Lang, Shanshan Zhang, Leina Lu, Xiaoxiao Liu, Yan Li, Fulai Jin   +7 more
doaj   +2 more sources

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion [PDF]

Nature, 2020
Nuclear processes, such as V(D)J recombination, are orchestrated by the three-dimensional organization of chromosomes at multiple levels, including compartments1 and topologically associated domains (TADs)2,3 consisting of chromatin loops4.
Markus Jaritz, Bönelt, Peter, Busslinger, Meinrad, Gordana Wutz, Hill, Louisa, Peters, Jan-Michael, Meinrad Busslinger, Tagoh, Hiromi, Karina Schindler, Ebert, Anja, Peter Bönelt, Wutz, Gordana, Maria Fischer, Schindler, Karina, Kostanova-Poliakova, Daniela, Daniela Kostanova-Poliakova, Jaritz, Markus, Nagasaka, Kota, Louisa Hill, Jan-Michael Peters, Kota Nagasaka, Anja Ebert, Fischer, Maria, Hiromi Tagoh, Qiong Sun, Sun, Qiong   +25 more
core   +5 more sources

S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion [PDF]

The EMBO Journal
Sororin is essential for establishing sister chromatid cohesion concurrently with DNA replication in metazoans. Although acetylation of the cohesin subunit SMC3 by ESCO1/2 is necessary for Sororin recruitment, it is by itself not sufficient.
Meiqian Jiang, Jiaxin Zhang, Jiankun He, Yu Miao, Linhui Wang, Haitao Zhong, Yingying Gong, Zhen Li, Li-Lin Du, Xingzhi Xu, Chunlai Chen, Alibek Ydyrys, Yisui Xia, Qinhong Cao, Huiqiang Lou, Wenya Hou   +15 more
doaj   +2 more sources

Cohesin positions the epigenetic reader Phf2 within the genome [PDF]

The EMBO Journal
Genomic DNA is assembled into chromatin by histones, and extruded into loops by cohesin. These mechanisms control important genomic functions, but whether histones and cohesin cooperate in genome regulation is poorly understood.
Wen Tang, Lorenzo Costantino, Roman Stocsits, Gordana Wutz, Rene Ladurner, Otto Hudecz, Karl Mechtler, Jan-Michael Peters   +7 more
doaj   +2 more sources