Results 21 to 30 of about 1,291 (151)

WAPL orchestrates porcine oocyte meiotic progression via control of spindle assembly checkpoint activity

Reproductive Biology and Endocrinology, 2021
Background In mitotic cells, WAPL acts as a cohesin release factor to remove cohesin complexes from chromosome arms during prophase to allow the accurate chromosome segregation in anaphase.
Changyin Zhou, Yilong Miao, Xue Zhang, Bo Xiong   +3 more
doaj   +1 more source

Where, When, and How? Integrating Spatiotemporal Cues in Cell Division. [PDF]

Bioessays
Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Cirillo L, Konthalapalli H, Alfieri C, Pines J.   +3 more
europepmc   +2 more sources

Rearrangement of T Cell genome architecture regulates GVHD

iScience, 2022
Summary: WAPL, cohesin’s DNA release factor, regulates three-dimensional (3D) chromatin architecture. The 3D chromatin structure and its relevance to mature T cell functions is not well understood.
Yaping Sun, Gabrielle A. Dotson, Lindsey A. Muir, Scott Ronquist, Katherine Oravecz-Wilson, Daniel Peltier, Keisuke Seike, Lu Li, Walter Meixner, Indika Rajapakse, Pavan Reddy   +10 more
doaj   +1 more source

Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression.

PLoS Genetics, 2022
The relationship between cohesin-mediated chromatin looping and gene expression remains unclear. NIPBL and WAPL are two opposing regulators of cohesin activity; depletion of either is associated with changes in both chromatin folding and transcription ...
Jennifer M Luppino, Andrew Field, Son C Nguyen, Daniel S Park, Parisha P Shah, Richard J Abdill, Yemin Lan, Rebecca Yunker, Rajan Jain, Karen Adelman, Eric F Joyce   +10 more
doaj   +1 more source

Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes

eLife, 2016
Wapl induces cohesin dissociation from DNA throughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure.
Oliver Crawley, Consuelo Barroso, Sarah Testori, Nuria Ferrandiz, Nicola Silva, Maikel Castellano-Pozo, Angel Luis Jaso-Tamame, Enrique Martinez-Perez   +7 more
doaj   +1 more source

A Wapl a Day Keeps the Sisters Apart: Wapl and Cohesin Dynamics [PDF]

Developmental Cell, 2006
Sister chromatids are held together by the cohesin complex from the time they are made until cell division. In recent articles published in Cell and Current Biology, the characterization of Wapl, a newly identified cohesin-interacting protein, suggests that a dynamic interaction between the cohesin complex and chromatin is important for normal ...
openaire   +2 more sources

Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells

Nature Communications, 2023
Extended loop extrusion across the immunoglobulin heavy-chain (Igh) locus facilitates VH-DJH recombination following downregulation of the cohesin-release factor Wapl by Pax5, resulting in global changes in the chromosomal architecture of pro-B cells ...
Louisa Hill, Gordana Wutz, Markus Jaritz, Hiromi Tagoh, Lesly Calderón, Jan-Michael Peters, Anton Goloborodko, Meinrad Busslinger   +7 more
doaj   +1 more source

K29-Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response. [PDF]

Adv Sci (Weinh)
Under endoplasmic reticulum stress, cells activate the unfolded protein response (UPR). During the UPR, the cohesin complex at the promoter of cell proliferation‐related genes undergoes K29‐linked ubiquitination, recruiting the cohesin release factor WAPL to release cohesin, leading to transcriptional downregulation and inhibition of cell growth ...
Zhang Q, Teng X, Dai Y, Wu Y, Hou H, Li J.   +5 more
europepmc   +2 more sources

Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers. [PDF]

Nucleic Acids Res
Abstract Interphase chromosomes are mainly shaped by loop extrusion and compartmentalisation mechanisms. However, their temporal component and cause-effect relationships remain largely unknown. In this study, we use acute degradation of WAPL, CTCF and cohesin in mouse embryonic stem cells to investigate the dynamics of loop extrusion ...
Liu NQ, Magnitov M, Schijns MMGA, van Schaik T, Teunissen H, van Steensel B, de Wit E.   +6 more
europepmc   +4 more sources

SORORIN is an evolutionary conserved antagonist of WAPL

, 2022
Abstract Cohesin mediates sister chromatid cohesion to enable chromosome segregation and DNA damage repair. To perform these functions, cohesin needs to be protected from WAPL, which otherwise releases cohesin from DNA. It has been proposed that cohesin is protected from WAPL by SORORIN.
Ignacio Prusen Mota, Marta Galova, Alexander Schleiffer, Tan-Trung Nguyen, Ines Kovacikova, Tomoko Nishiyama, Juraj Gregan, Jan-Michael Peters, Peter Schlögelhofer   +8 more
openaire   +1 more source