Budding Yeast Wapl Controls Sister Chromatid Cohesion Maintenance and Chromosome Condensation [PDF]
Current Biology, 2013 SummaryThe establishment of stable sister chromatid cohesion during DNA replication requires acetylation of the chromosomal cohesin complex by the replication fork-associated acetyltransferase Eco1 [1–8].
Borges, Vanessa +4 more
core +3 more sources
WAPL-Mediated Removal of Cohesin Protects against Segregation Errors and Aneuploidy [PDF]
Current Biology, 2013 SummaryThe classical X shape of mitotic human chromosomes is the consequence of two distinct waves of cohesin removal. First, during prophase and prometaphase, the bulk of cohesin is driven from chromosome arms by the cohesin antagonist WAPL.
Haarhuis, Judith H.I. +7 more
core +3 more sources
S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion [PDF]
The EMBO JournalSororin is essential for establishing sister chromatid cohesion concurrently with DNA replication in metazoans. Although acetylation of the cohesin subunit SMC3 by ESCO1/2 is necessary for Sororin recruitment, it is by itself not sufficient.
Meiqian Jiang +15 more
doaj +2 more sources
Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.
PLoS Genetics, 2018 The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B-Mau2 protein complex
Ziva Misulovin +3 more
doaj +2 more sources
A non-canonical role of the inner kinetochore in regulating sister-chromatid cohesion at centromeres [PDF]
The EMBO JournalThe 16-subunit Constitutive Centromere-associated Network (CCAN)-based inner kinetochore is well-known for connecting centromeric chromatin to the spindle-binding outer kinetochore.
Lu Yan +12 more
doaj +2 more sources
Cohesin positions the epigenetic reader Phf2 within the genome [PDF]
The EMBO JournalGenomic DNA is assembled into chromatin by histones, and extruded into loops by cohesin. These mechanisms control important genomic functions, but whether histones and cohesin cooperate in genome regulation is poorly understood.
Wen Tang +7 more
doaj +2 more sources
Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function
PLOS Genetics, 2017 The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription.
Maria Gause +3 more
core +5 more sources
Cooperative Roles of Pds5a and Pds5b Constrain Long-Range Chromatin Interactions in Vertebrate Embryos. [PDF]
Dev Growth DifferABSTRACT Three‐dimensional (3D) genome organization is dynamically restructured during early vertebrate development, yet how chromatin domains are established remains poorly understood. In particular, the contribution of individual cohesin regulators to this process during embryogenesis is unclear.
Ikeda S, Takeda H, Nakamura R.
europepmc +2 more sources
Where, When, and How? Integrating Spatiotemporal Cues in Cell Division. [PDF]
BioessaysAccurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Cirillo L +3 more
europepmc +2 more sources
Reproductive Biology and Endocrinology, 2021 Background In mitotic cells, WAPL acts as a cohesin release factor to remove cohesin complexes from chromosome arms during prophase to allow the accurate chromosome segregation in anaphase.
Changyin Zhou +3 more
doaj +1 more source