Results 71 to 80 of about 11,947 (194)

Nuclear Import and Export Signals of Human Cohesins SA1/STAG1 and SA2/STAG2 Expressed in Saccharomyces cerevisiae [PDF]

, 2012
Background: Human SA/STAG proteins, homologues of the yeast Irr1/Scc3 cohesin, are the least studied constituents of the sister chromatid cohesion complex crucial for proper chromosome segregation.
Jurek, Marta, Leszek J. Tarnowski (160129), Milewski Michał, Michał Milewski (160136), Milewski, Michał, Plochocka, Danuta, Kurlandzka, Anna, Anna Kurlandzka, Marta Jurek, Kowalec, Piotr, Tarnowski, Leszek J, Jan Fronk, Jurek Marta, Piotr Kowalec, Tarnowski Leszek J., Danuta Plochocka, Jan Fronk (160145), Kowalec Piotr, Fronk Jan, Plochocka Danuta, Piotr Kowalec (160133), Fronk, Jan, Leszek J Tarnowski, Michał Milewski, Marta Jurek (160140), Kurlandzka Anna, Anna Kurlandzka (160147), Danuta Plochocka (160143)   +27 more
core   +1 more source

Chl1 DNA helicase regulates Scc2 deposition specifically during DNA-replication in Saccharomyces cerevisiae.

PLoS ONE, 2013
The conserved family of cohesin proteins that mediate sister chromatid cohesion requires Scc2, Scc4 for chromatin-association and Eco1/Ctf7 for conversion to a tethering competent state.
Soumya Rudra, Robert V Skibbens
doaj   +1 more source

A Long Noncoding RNA Regulates Sister Chromatid Cohesion. [PDF]

Mol Cell, 2016
Long noncoding RNAs (lncRNAs) are involved in diverse cellular processes through multiple mechanisms. Here, we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), that is transcriptionally activated by MYC and is upregulated in multiple cancer types.
Marchese FP, Grossi E, Marín-Béjar O, Bharti SK, Raimondi I, González J, Martínez-Herrera DJ, Athie A, Amadoz A, Brosh RM, Huarte M.   +10 more
europepmc   +7 more sources

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, EarlyView.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

CDK11p58 is required for the maintenance of sister chromatid cohesion [PDF]

Journal of Cell Science, 2007
Cyclin-dependent kinase 11 (CDK11) mRNA produces a 110-kDa protein (CDK11p110) throughout the cell cycle and a 58-kDa protein (CDK11p58) that is specifically translated from an internal ribosome entry site sequence during G2/M. CDK11p110 is involved in transcription and RNA processing, and CDK11p58 is involved in centrosome maturation and spindle ...
Dongli, Hu, Marcus, Valentine, Vincent J, Kidd, Jill M, Lahti   +3 more
openaire   +2 more sources

How to halve ploidy : lessons from budding yeast meiosis [PDF]

, 2012
Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Kerr, Gary W., Kerr, Gary, Sarkar, Sourav, Arumugam, Prakash   +3 more
core   +1 more source

Analysis of Meiotic Sister Chromatid Cohesion in Caenorhabditis elegans. [PDF]

Methods Mol Biol, 2017
In sexually reproducing organisms, the formation of healthy gametes (sperm and eggs) requires the proper establishment and release of meiotic sister chromatid cohesion (SCC). SCC tethers replicated sisters from their formation in premeiotic S phase until the stepwise removal of cohesion in anaphase of meiosis I and II allows the separation of homologs ...
Severson AF.
europepmc   +4 more sources

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, Volume 46, Issue 8, Page 2599-2622, August 2026.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

A Water‐Saving Drought Survival Phenotype in a Wheat TILLING Mutant Involves Survival‐Biased Metabolic and Phosphorylation Reprogramming

Plant, Cell &Environment, Volume 49, Issue 8, Page 5435-5449, August 2026.
ABSTRACT Drought tolerance in crops often involves trade‐offs between water conservation, growth and reproduction. Understanding how water‐saving strategies are implemented at physiological and metabolic levels remains critical for improving crop performance under water‐limited conditions.
Ryosuke Mega, Shun‐ichiro Hirata, Kota Yamashita, Hinano Takase, Taishi Umezawa, Yasuko Watanabe, June‐Sik Kim, Tomoyuki Kosaka, Akihiro Nieda, Hisashi Tsujimoto   +9 more
wiley   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source