Results 71 to 80 of about 10,437 (162)
Journal of Applied Toxicology, EarlyView.ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza +2 more
wiley +1 more source
CDK11p58 is required for the maintenance of sister chromatid cohesion [PDF]
Journal of Cell Science, 2007 Cyclin-dependent kinase 11 (CDK11) mRNA produces a 110-kDa protein (CDK11p110) throughout the cell cycle and a 58-kDa protein (CDK11p58) that is specifically translated from an internal ribosome entry site sequence during G2/M. CDK11p110 is involved in transcription and RNA processing, and CDK11p58 is involved in centrosome maturation and spindle ...
Dongli, Hu +3 more
openaire +2 more sources
Analysis of Meiotic Sister Chromatid Cohesion in Caenorhabditis elegans. [PDF]
Methods Mol Biol, 2017 In sexually reproducing organisms, the formation of healthy gametes (sperm and eggs) requires the proper establishment and release of meiotic sister chromatid cohesion (SCC). SCC tethers replicated sisters from their formation in premeiotic S phase until the stepwise removal of cohesion in anaphase of meiosis I and II allows the separation of homologs ...
Severson AF.
europepmc +4 more sources
Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development
Cancer Science, EarlyView.Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura +3 more
wiley +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Drought tolerance in crops often involves trade‐offs between water conservation, growth and reproduction. Understanding how water‐saving strategies are implemented at physiological and metabolic levels remains critical for improving crop performance under water‐limited conditions.
Ryosuke Mega +9 more
wiley +1 more source
Sororin, the Cell Cycle and Sister Chromatid Cohesion [PDF]
Cell Cycle, 2005 Sister chromatid cohesion is essential for the maintenance of genome integrity. Errors in regulation of cohesion result in increased sensitivity to DNA damage, mis-segregation of chromosomes, and loss of genetic information. We recently showed that sororin is an essential regulator of sister chromatid cohesion in vertebrates.
openaire +2 more sources
Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
What is your assay for sister‐chromatid cohesion? [PDF]
The EMBO Journal, 2007 Long hikes, for which my father took us, made me appreciate the wonderful nature that surrounded us in southern Germany. Nocturnal stargazing walks, together with popular science books that my aunt supplied, started my excitement for particle physics and the origin of the universe, a fashionable topic at the time.
openaire +2 more sources
The cohesin complex of yeasts: sister chromatid cohesion and beyond
FEMS Microbiology Reviews, 2022 AbstractEach time a cell divides, it needs to duplicate the genome and then separate the two copies. In eukaryotes, which usually have more than one linear chromosome, this entails tethering the two newly replicated DNA molecules, a phenomenon known as sister chromatid cohesion (SCC).
Karan Choudhary, Martin Kupiec
openaire +2 more sources
PLoS Biology, 2020 During meiosis, chromosomes adopt a specialized organization involving assembly of a cohesin-based axis along their lengths, with DNA loops emanating from this axis.
Alexander Woglar +5 more
doaj +1 more source