Results 81 to 90 of about 11,947 (194)
Sororin, the Cell Cycle and Sister Chromatid Cohesion [PDF]
Cell Cycle, 2005 Sister chromatid cohesion is essential for the maintenance of genome integrity. Errors in regulation of cohesion result in increased sensitivity to DNA damage, mis-segregation of chromosomes, and loss of genetic information. We recently showed that sororin is an essential regulator of sister chromatid cohesion in vertebrates.
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Sororin, a Substrate of the Anaphase- Promoting Complex, Is Required for Sister Chromatid Cohesion in Vertebrates [PDF]
, 2005 We have identified a regulator of sister chromatid cohesion in a screen for cell cycle-controlled proteins. This 35 kDa protein is degraded through anaphase-promoting complex (APC)-dependent ubiquitination in G1.
Kirschner, Marc W +2 more
core +1 more source
What is your assay for sister‐chromatid cohesion? [PDF]
The EMBO Journal, 2007 Long hikes, for which my father took us, made me appreciate the wonderful nature that surrounded us in southern Germany. Nocturnal stargazing walks, together with popular science books that my aunt supplied, started my excitement for particle physics and the origin of the universe, a fashionable topic at the time.
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The cohesin complex of yeasts: sister chromatid cohesion and beyond
FEMS Microbiology Reviews, 2022 AbstractEach time a cell divides, it needs to duplicate the genome and then separate the two copies. In eukaryotes, which usually have more than one linear chromosome, this entails tethering the two newly replicated DNA molecules, a phenomenon known as sister chromatid cohesion (SCC).
Karan Choudhary, Martin Kupiec
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The Origin Recognition Complex Functions in Sister-Chromatid Cohesion in Saccharomyces cerevisiae [PDF]
, 2007 SummaryHigh-fidelity chromosomal segregation requires the properly timed establishment of sister-chromatid cohesion mediated by the Cohesin complex, and its resolution at the metaphase-to-anaphase transition.
Shimada, Kenji, Gasser, Susan M.
core +1 more source
International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte +10 more
wiley +1 more source
PLoS Biology, 2020 During meiosis, chromosomes adopt a specialized organization involving assembly of a cohesin-based axis along their lengths, with DNA loops emanating from this axis.
Alexander Woglar +5 more
doaj +1 more source
The Polymers of Life: Exploring Cellular Function Through Polymer Concepts
Advanced Science, Volume 13, Issue 33, 15 June 2026.Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley +1 more source
Regulation of Sister Chromatid Cohesion between Chromosome Arms [PDF]
Current Biology, 2004 Sister chromatid separation in anaphase depends on the removal of cohesin complexes from chromosomes. In vertebrates, the bulk of cohesin is already removed from chromosome arms during prophase and prometaphase, whereas cohesin remains at centromeres until metaphase, when cohesin is cleaved by the protease separase. In unperturbed mitoses, arm cohesion
Giménez-Abián, Juan F. +7 more
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Genomic analysis of cohesin dynamics in fission yeast [PDF]
, 2009 Cohesin holds sister chromatids together and facilitates their accurate segregation in mitosis. Little is known about how and where cohesin binds to chromosomes.
Schmidt, C.K., Schmidt, C K
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