Results 101 to 110 of about 921,868 (189)

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

Crystal Structure of the Cohesin Gatekeeper Pds5 and in Complex with Kleisin Scc1

Cell Reports, 2016
Sister chromatid cohesion is mediated by cohesin, whose Smc1, Smc3, and kleisin (Scc1) subunits form a ring structure that entraps sister DNAs. The ring is opened either by separase, which cleaves Scc1 during anaphase, or by a releasing activity ...
Byung-Gil Lee, Maurici B. Roig, Marijke Jansma, Naomi Petela, Jean Metson, Kim Nasmyth, Jan Löwe   +6 more
doaj   +1 more source

Recent advances in understanding the role of Cdk1 in the Spindle Assembly Checkpoint [version 1; peer review: 2 approved]

F1000Research, 2020
The goal of mitosis is to form two daughter cells each containing one copy of each mother cell chromosome, replicated in the previous S phase. To achieve this, sister chromatids held together back-to-back at their primary constriction, the centromere ...
Angela Flavia Serpico, Domenico Grieco
doaj   +1 more source

Sister chromatid cohesion is mediated by individual cohesin complexes [PDF]

Eukaryotic genomes are organized by loop extrusion and sister chromatid cohesion, both mediated by the multimeric cohesin protein complex. Understanding how cohesin holds sister DNAs together, and how loss of cohesion causes age-related infertility in ...
Brown, Jill, Schermelleh, Lothar, Ochs, Fena, Kolesnikova, Sofia, Green, Charlotte, Nasmyth, Kim Ashley, Gerlich, Daniel Wolfram, Buckle, Veronica, Pytowski, Lior, Szczurek, Aleksander   +9 more
core   +1 more source

Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.

PLoS ONE, 2010
Multiple genome maintenance processes are coordinated at the replication fork to preserve genomic integrity. How eukaryotic cells accomplish such a coordination is unknown.
Jordan B Rapp, Chiaki Noguchi, Mukund M Das, Lisa K Wong, Alison B Ansbach, Allyson M Holmes, Benoit Arcangioli, Eishi Noguchi   +7 more
doaj   +1 more source

Regulation of Sister-Chromatid Cohesion

, 2017
Orderly execution of two critical events during the cell cycle--DNA replication and chromosome segregation--ensures the stable transmission of genetic materials.
Zheng, Ge
core  

How to halve ploidy : lessons from budding yeast meiosis [PDF]

, 2012
Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Kerr, Gary W., Kerr, Gary, Sarkar, Sourav, Arumugam, Prakash   +3 more
core   +1 more source

DNA catenation is essential for Sister Chromatid Cohesion

From S phase until anaphase, sister chromatids remain physically linked to ensure accurate chromosome segregation. This linkage, called sister chromatid cohesion, must withstand the pulling forces generated by the mitotic spindle and is thought to ...
Kristian Jeppsson, Aditi Kaushik, Raquel A Oliveira, Toyonori Sakata, Andres H Maduro, Alejandro M Martin, Madhusudhan Srinivasan, James Collier, Jumpei Fukute, Katsuhiko Shirahige, Joaquim Roca, Vanessa Viera, Alba A Fraile   +12 more
core   +1 more source

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

eLife, 2017
Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers. Here we demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction
Petra van der Lelij, Simone Lieb, Julian Jude, Gordana Wutz, Catarina P Santos, Katrina Falkenberg, Andreas Schlattl, Jozef Ban, Raphaela Schwentner, Thomas Hoffmann, Heinrich Kovar, Francisco X Real, Todd Waldman, Mark A Pearson, Norbert Kraut, Jan-Michael Peters, Johannes Zuber, Mark Petronczki   +17 more
doaj   +1 more source

Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells.

PLoS Biology, 2005
Cohesion between sister chromatids is essential for their bi-orientation on mitotic spindles. It is mediated by a multisubunit complex called cohesin.
Barry E McGuinness, Toru Hirota, Nobuaki R Kudo, Jan-Michael Peters, Kim Nasmyth   +4 more
doaj   +1 more source