Results 91 to 100 of about 11,947 (194)

Two Putative Acetyltransferases, San and Deco, Are Required for Establishing Sister Chromatid Cohesion in Drosophila [PDF]

, 2003
Background: Sister chromatid cohesion is needed for proper alignment and segregation of chromosomes during cell division. Chromatids are linked by the multiprotein cohesin complex, which binds to DNA during G1 and then establishes cohesion during S phase
Goldberg, Michael L., Elizabeth D. Rosenman, Williams, Erika V., Byron C. Williams, Michael L. Goldberg, Rosenman, Elizabeth D., Carrie M. Garrett-Engele, Erika V. Williams, Zexiao Li, Williams, Byron C., Garrett-Engele, Carrie M., Li, Zexiao   +11 more
core   +1 more source

The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells [PDF]

, 2006
It has recently been suggested that the Saccharomyces cerevisiae protein Chl1p plays a role in cohesion establishment. Here, we show that the human ATP-dependent DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells ...
Wang, X, Androphy, Elliot J., Rosa, J, Parish, Joanna L.; id_orcid, Parish, Joanna Louise, Lahti, JM, Lahti, Jill M., Wang, Xiaoyu, Doxsey, SJ, Doxsey, Stephen J., Androphy, EJ, Rosa, Jack   +11 more
core   +3 more sources

Evolutionary Patterns of the Genes Involved in the Integrity and Segregation of Chromosomes in Sawflies (Hymenoptera: Symphyta)

Ecology and Evolution, Volume 16, Issue 6, June 2026.
This study identifies and characterizes the genes encoding cohesin and condensin complexes across Symphytan superfamilies, revealing their structural and functional roles with conserved motifs in maintaining genome stability. Phylogenetic analyses indicate that SMC genes originated from ancient duplication events, with notable gene loss (e.g., CAPG2 ...
Ayşe Rümeysa Nalça, Ertan Mahir Korkmaz   +1 more
wiley   +1 more source

Cohesion decay: quantitative analysis of partial sister chromatid cohesion [PDF]

, 2014
Cell division is a highly dynamic process where sister chromatids remain associated with each other from the moment of DNA replication until the later stages of mitosis, giving rise to two daughter cells with equal genomes.
Santos, Mariana Batista
core  

A single-molecule approach to understanding sister chromatid cohesion establishment [PDF]

Sister chromatid cohesion is established by the cohesin complex during DNA replication in S phase. This process requires cohesin to transition from binding to one DNA strand to co-entrapping the two newly synthesised sister chromatids.
Glaser, Samson
core   +1 more source

The chromosomal association of the Smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement.

PLoS Genetics, 2014
The cohesin complex, which is essential for sister chromatid cohesion and chromosome segregation, also inhibits resolution of sister chromatid intertwinings (SCIs) by the topoisomerase Top2. The cohesin-related Smc5/6 complex (Smc5/6) instead accumulates
Kristian Jeppsson, Kristian K Carlborg, Ryuichiro Nakato, Davide G Berta, Ingrid Lilienthal, Takaharu Kanno, Arne Lindqvist, Maartje C Brink, Nico P Dantuma, Yuki Katou, Katsuhiko Shirahige, Camilla Sjögren   +11 more
doaj   +1 more source

Mutation type‐specific transcriptomic signatures and readthrough therapy rescue in SMC1A‐related developmental and epileptic encephalopathy

Epilepsia, Volume 67, Issue 6, Page 3185-3198, June 2026.
Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo, Francesca Sardina, Maria M. Pallotta, Iñigo Marcos‐Alcalde, Paulino Gómez‐Puertas, Cinzia Rinaldo, Ian D. Krantz, Antonio Musio   +7 more
wiley   +1 more source

Pds5 cooperates with cohesin in maintaining sister chromatid cohesion [PDF]

, 2000
Background: Sister chromatid cohesion depends on a complex called cohesin, which contains at least four subunits: Smc1, Smc3, Scc1 and Scc3. Cohesion is established during DNA replication, is partially dismantled in many, but not all, organisms during ...
Silvia Panizza, Tanaka, Tomoyuki, Kim Nasmyth, Panizza, Silvia, Nasmyth, Kim, Andreas Hochwagen, Frank Eisenhaber, Hochwagen, Andreas, Eisenhaber, Frank, Tomoyuki Tanaka   +9 more
core   +1 more source

Silencing SGO2 by Oxamic Acid Dissociates Glycolysis and BRCA1‐Mediated DNA Repair to Improve the Chemosensitivity of Lung Adenocarcinoma

Exploration, Volume 6, Issue 3, June 2026.
SGO2 interacts with BRCA1 to inhibit BRCA1 ubiquitination and degradation, thereby promoting BRCA1‐induced DNA damage repair signaling and reducing the chemo sensitivity of LUADa. OA targets glycolysis to disrupt H3K18la‐ and H3K27ac‐mediated chromatin accessibility, repressing SGO2 transcription and subsequently alleviating SGO2‐mediated cancer ...
Xian Lin, Zhidan Hua, Chen Liu, Minxia Yang, Beilei Zhang, Xiaofeng Zhu, Xiao Chen   +6 more
wiley   +1 more source

Sister chromatid cohesion and genome stability in vertebrate cells [PDF]

, 2003
For successful eukaryotic mitosis, sister chromatid pairs remain linked after replication until their kinetochores have been attached to opposite spindle poles by microtubules.
Morrison, C., Sonoda, E., Takeda, S., Earnshaw, W.C., Vagnarelli, P.   +4 more
core   +1 more source