Results 91 to 100 of about 10,437 (162)

Structural evidence for Scc4-dependent localization of cohesin loading

eLife, 2015
The cohesin ring holds newly replicated sister chromatids together until their separation at anaphase. Initiation of sister chromatid cohesion depends on a separate complex, Scc2NIPBL/Scc4Mau2 (Scc2/4), which loads cohesin onto DNA and determines its ...
Stephen M Hinshaw, Vasso Makrantoni, Alastair Kerr, Adèle L Marston, Stephen C Harrison   +4 more
doaj   +1 more source

Cooperative Roles of Pds5a and Pds5b Constrain Long‐Range Chromatin Interactions in Vertebrate Embryos

Development, Growth &Differentiation, Volume 68, Issue 3, April 2026.
ABSTRACT Three‐dimensional (3D) genome organization is dynamically restructured during early vertebrate development, yet how chromatin domains are established remains poorly understood. In particular, the contribution of individual cohesin regulators to this process during embryogenesis is unclear.
Shinra Ikeda, Hiroyuki Takeda, Ryohei Nakamura   +2 more
wiley   +1 more source

Recent advances in understanding the role of Cdk1 in the Spindle Assembly Checkpoint [version 1; peer review: 2 approved]

F1000Research, 2020
The goal of mitosis is to form two daughter cells each containing one copy of each mother cell chromosome, replicated in the previous S phase. To achieve this, sister chromatids held together back-to-back at their primary constriction, the centromere ...
Angela Flavia Serpico, Domenico Grieco
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, Volume 20, Issue 3, Page 709-726, March 2026.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Crystal Structure of the Cohesin Gatekeeper Pds5 and in Complex with Kleisin Scc1

Cell Reports, 2016
Sister chromatid cohesion is mediated by cohesin, whose Smc1, Smc3, and kleisin (Scc1) subunits form a ring structure that entraps sister DNAs. The ring is opened either by separase, which cleaves Scc1 during anaphase, or by a releasing activity ...
Byung-Gil Lee, Maurici B. Roig, Marijke Jansma, Naomi Petela, Jean Metson, Kim Nasmyth, Jan Löwe   +6 more
doaj   +1 more source

Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.

PLoS ONE, 2010
Multiple genome maintenance processes are coordinated at the replication fork to preserve genomic integrity. How eukaryotic cells accomplish such a coordination is unknown.
Jordan B Rapp, Chiaki Noguchi, Mukund M Das, Lisa K Wong, Alison B Ansbach, Allyson M Holmes, Benoit Arcangioli, Eishi Noguchi   +7 more
doaj   +1 more source

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

eLife, 2017
Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers. Here we demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction
Petra van der Lelij, Simone Lieb, Julian Jude, Gordana Wutz, Catarina P Santos, Katrina Falkenberg, Andreas Schlattl, Jozef Ban, Raphaela Schwentner, Thomas Hoffmann, Heinrich Kovar, Francisco X Real, Todd Waldman, Mark A Pearson, Norbert Kraut, Jan-Michael Peters, Johannes Zuber, Mark Petronczki   +17 more
doaj   +1 more source

Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells.

PLoS Biology, 2005
Cohesion between sister chromatids is essential for their bi-orientation on mitotic spindles. It is mediated by a multisubunit complex called cohesin.
Barry E McGuinness, Toru Hirota, Nobuaki R Kudo, Jan-Michael Peters, Kim Nasmyth   +4 more
doaj   +1 more source

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.

PLoS Genetics, 2009
Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion by connecting replicated DNA molecules. Cohesin also has important roles in gene regulation, but the mechanistic basis of this function is poorly understood.
Raffaella Nativio, Kerstin S Wendt, Yoko Ito, Joanna E Huddleston, Santiago Uribe-Lewis, Kathryn Woodfine, Christel Krueger, Wolf Reik, Jan-Michael Peters, Adele Murrell   +9 more
doaj   +1 more source

Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromatin

The EMBO Journal
Sister chromatid cohesion is mediated by the cohesin complex. In mitotic prophase cohesin is removed from chromosome arms in a Wapl- and phosphorylation-dependent manner. Sgo1-PP2A protects pericentromeric cohesion by dephosphorylation of cohesin and its
Susanne Hellmuth, Olaf Stemmann
doaj   +1 more source