Results 91 to 100 of about 921,868 (189)

Transcription facilitates sister chromatid cohesion on chromosomal arms [PDF]

Nucleic Acids Research, 2016
Cohesin is a multi-subunit protein complex essential for sister chromatid cohesion, gene expression and DNA damage repair. Although structurally well studied, the underlying determinant of cohesion establishment on chromosomal arms remains enigmatic. Here, we show two populations of functionally distinct cohesin on chromosomal arms using a combination ...
Bhardwaj, S, Schlackow, M, Rabajdova, M, Gullerova, M   +3 more
openaire   +2 more sources

Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition.

PLoS ONE, 2017
Chl1 DNA helicase promotes sister chromatid cohesion and associates with both the cohesion establishment acetyltransferase Eco1/Ctf7 and the DNA polymerase processivity factor PCNA that supports Eco1/Ctf7 function.
Donglai Shen, Robert V Skibbens
doaj   +1 more source

Characterization of global and region‐specific transcriptomic alterations in the bladder following acute partial bladder outlet obstruction in female mini‐swine

Physiological Reports, Volume 14, Issue 16, August 2026.
Abstract Partial bladder outlet obstruction (pBOO) is a fibroproliferative disorder that results in poorly compliant, high‐pressure bladders due to lower urinary tract occlusion. The mechanisms governing pBOO‐induced bladder remodeling remain poorly understood.
Yi Xi Wu, Gokhan Gundogdu, Madison Rivero, Caila Ruiz‐May, Ahmet Tarik Gundogdu, Victor Pham, Keith Rourke, Zhina Sadeghi, Joel Gelman, Joshua R. Mauney   +9 more
wiley   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

Cohesion decay: quantitative analysis of partial sister chromatid cohesion [PDF]

, 2014
Cell division is a highly dynamic process where sister chromatids remain associated with each other from the moment of DNA replication until the later stages of mitosis, giving rise to two daughter cells with equal genomes.
Santos, Mariana Batista
core  

Nuclear Import and Export Signals of Human Cohesins SA1/STAG1 and SA2/STAG2 Expressed in Saccharomyces cerevisiae [PDF]

, 2012
Background: Human SA/STAG proteins, homologues of the yeast Irr1/Scc3 cohesin, are the least studied constituents of the sister chromatid cohesion complex crucial for proper chromosome segregation.
Jurek, Marta, Leszek J. Tarnowski (160129), Milewski Michał, Michał Milewski (160136), Milewski, Michał, Plochocka, Danuta, Kurlandzka, Anna, Anna Kurlandzka, Marta Jurek, Kowalec, Piotr, Tarnowski, Leszek J, Jan Fronk, Jurek Marta, Piotr Kowalec, Tarnowski Leszek J., Danuta Plochocka, Jan Fronk (160145), Kowalec Piotr, Fronk Jan, Plochocka Danuta, Piotr Kowalec (160133), Fronk, Jan, Leszek J Tarnowski, Michał Milewski, Marta Jurek (160140), Kurlandzka Anna, Anna Kurlandzka (160147), Danuta Plochocka (160143)   +27 more
core   +1 more source

Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis

Nature Communications, 2018
During meiosis, step-wise release of sister chromatid cohesion mediated by REC-8 cohesin is required for the formation of haploid gametes. Here, the authors show that in C.
Nuria Ferrandiz, Consuelo Barroso, Oana Telecan, Nan Shao, Hyun-Min Kim, Sarah Testori, Peter Faull, Pedro Cutillas, Ambrosius P. Snijders, Monica P. Colaiácovo, Enrique Martinez-Perez   +10 more
doaj   +1 more source

Structural evidence for Scc4-dependent localization of cohesin loading

eLife, 2015
The cohesin ring holds newly replicated sister chromatids together until their separation at anaphase. Initiation of sister chromatid cohesion depends on a separate complex, Scc2NIPBL/Scc4Mau2 (Scc2/4), which loads cohesin onto DNA and determines its ...
Stephen M Hinshaw, Vasso Makrantoni, Alastair Kerr, Adèle L Marston, Stephen C Harrison   +4 more
doaj   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Manipulating sister chromatid cohesion to prevent aneuploidy

Oocyte aneuploidy has been shown to be one of the major causes of age-dependent aneuploidy which can lead to trisomic pregnancies, miscarriages and an overall decrease in fertility rates.
Muñoz Grande, Alba
core   +1 more source