Results 111 to 120 of about 921,868 (189)

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.

PLoS Genetics, 2009
Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion by connecting replicated DNA molecules. Cohesin also has important roles in gene regulation, but the mechanistic basis of this function is poorly understood.
Raffaella Nativio, Kerstin S Wendt, Yoko Ito, Joanna E Huddleston, Santiago Uribe-Lewis, Kathryn Woodfine, Christel Krueger, Wolf Reik, Jan-Michael Peters, Adele Murrell   +9 more
doaj   +1 more source

Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromatin

The EMBO Journal
Sister chromatid cohesion is mediated by the cohesin complex. In mitotic prophase cohesin is removed from chromosome arms in a Wapl- and phosphorylation-dependent manner. Sgo1-PP2A protects pericentromeric cohesion by dephosphorylation of cohesin and its
Susanne Hellmuth, Olaf Stemmann
doaj   +1 more source

Topology and structure of an engineered human cohesin complex bound to Pds5B

Nature Communications, 2016
Cohesin is a ring-shaped protein complex that structures chromatin and mediates sister chromatid cohesion. Here the authors rigidify cohesin using engineered Smc1 and Smc3 and generated 3D models showing how Pds5B forms an integral part of the cohesin ...
Michael T. Hons, Pim J. Huis in ‘t Veld, Jan Kaesler, Pascaline Rombaut, Alexander Schleiffer, Franz Herzog, Holger Stark, Jan-Michael Peters   +7 more
doaj   +1 more source

The Origin Recognition Complex Functions in Sister-Chromatid Cohesion in Saccharomyces cerevisiae [PDF]

, 2007
SummaryHigh-fidelity chromosomal segregation requires the properly timed establishment of sister-chromatid cohesion mediated by the Cohesin complex, and its resolution at the metaphase-to-anaphase transition.
Shimada, Kenji, Gasser, Susan M.
core   +1 more source

Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

Nature Communications, 2017
Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase ...
Ibtissem Nabti, Rosanna Grimes, Hema Sarna, Petros Marangos, John Carroll   +4 more
doaj   +1 more source

A replication fork determinant for the establishment of sister chromatid cohesion. [PDF]

Cell, 2023
Minamino M, Bouchoux C, Canal B, Diffley JFX, Uhlmann F.   +4 more
europepmc   +1 more source

PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion. [PDF]

Nat Struct Mol Biol, 2023
Psakhye I, Kawasumi R, Abe T, Hirota K, Branzei D.   +4 more
europepmc   +1 more source

CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin. [PDF]

Nucleic Acids Res, 2023
van Schie JJM, de Lint K, Molenaar TM, Moronta Gines M, Balk JA, Rooimans MA, Roohollahi K, Pai GM, Borghuis L, Ramadhin AR, Corazza F, Dorsman JC, Wendt KS, Wolthuis RMF, de Lange J.   +14 more
europepmc   +1 more source

Keeping sisters together: cohesin and Ycs4 define distinct mechanisms for sister chromatid cohesion [PDF]

, 2005
The maintenance of genetic integrity during the eukaryotic cell cycle requires sister chromatid cohesion and chromosome condensation. I show that Ycs4p, a subunit of the condensin complex, has an important role in sister chromatid cohesion.
Lam, Wendy W
core   +1 more source

MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC. [PDF]

Life Sci Alliance, 2023
van Schie JJ, de Lint K, Pai GM, Rooimans MA, Wolthuis RM, de Lange J.   +5 more
europepmc   +1 more source