Quantitative proteomic analysis of chromatin reveals that Ctf18 acts in the DNA replication checkpoint [PDF]
, 2011 Peer ...
Hiraga, Shin-ichiro +12 more
core +1 more source
The plant adherin AtSCC2 is required for embryogenesis and sister-chromatid cohesion during meiosis in Arabidopsis [PDF]
, 2009 Adherin plays an important role in loading the cohesin complex onto chromosomes, and is essential for the establishment of sister-chromatid cohesion. We have identified and analyzed the Arabidopsis adherin homolog AtSCC2.
Sebastian, Jose +5 more
core +1 more source
A SUMO-Dependent Step during Establishment of Sister Chromatid Cohesion [PDF]
, 2012 SummaryCohesin is a protein complex that ties sister DNA molecules from the time of DNA replication until the metaphase to anaphase transition. Current models propose that the association of the Smc1, Smc3, and Scc1/Mcd1 subunits creates a ring-shaped ...
Bermúdez-López, Marcelino +4 more
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Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts
eLife, 2017 Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers. Here we demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction
Petra van der Lelij +17 more
doaj +1 more source
Keeping sisters together: cohesin and Ycs4 define distinct mechanisms for sister chromatid cohesion [PDF]
, 2005 The maintenance of genetic integrity during the eukaryotic cell cycle requires sister chromatid cohesion and chromosome condensation. I show that Ycs4p, a subunit of the condensin complex, has an important role in sister chromatid cohesion.
Lam, Wendy W
core +1 more source
C-terminus of Sororin interacts with SA2 and regulates sister chromatid cohesion [PDF]
, 2015 Sororin is a conserved protein required for accurate separation of sister chromatids in each cell cycle. Sororin is recruited to chromatin during DNA replication, protects sister chromatid cohesion in S and G2 phase, and regulates the resolution of ...
Nenggang Zhang (212531) +1 more
core +1 more source
Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells.
PLoS Biology, 2005 Cohesion between sister chromatids is essential for their bi-orientation on mitotic spindles. It is mediated by a multisubunit complex called cohesin.
Barry E McGuinness +4 more
doaj +1 more source
CRL7SMU1 E3 ligase complex driven H2B ubiquitination functions in sister chromatid cohesion by regulating SMC1 expression [PDF]
, 2018 Cullin–RING E3 ligases (CRLs) control broad range of biological processes by ubiquitinating numerous cellular substrates. However, role of CRL E3 ligases in chromatid cohesion is unknown.
Subbareddy Maddika +1 more
core +1 more source
Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.
PLoS Genetics, 2009 Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion by connecting replicated DNA molecules. Cohesin also has important roles in gene regulation, but the mechanistic basis of this function is poorly understood.
Raffaella Nativio +9 more
doaj +1 more source
Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromatin
The EMBO JournalSister chromatid cohesion is mediated by the cohesin complex. In mitotic prophase cohesin is removed from chromosome arms in a Wapl- and phosphorylation-dependent manner. Sgo1-PP2A protects pericentromeric cohesion by dephosphorylation of cohesin and its
Susanne Hellmuth, Olaf Stemmann
doaj +1 more source